{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:25:07Z","timestamp":1789500307736,"version":"build-2803163510"},"reference-count":40,"publisher":"Korean Association for the Study of Intestinal Diseases","issue":"3","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2023R1A2C2005817"],"award-info":[{"award-number":["2023R1A2C2005817"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1A5A2021614"],"award-info":[{"award-number":["2021R1A5A2021614"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2023IT0006"],"award-info":[{"award-number":["2023IT0006"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["irjournal.org"],"crossmark-restriction":true},"short-container-title":["Intest Res"],"published-print":{"date-parts":[[2025,7,30]]},"abstract":"<jats:p>Background\/Aims: Video capsule endoscopy is rarely used to diagnose Crohn\u2019s disease in patients with negative ileocolonoscopy or cross-sectional image findings. We evaluated clinical characteristics and long-term outcomes of these rare cases. Methods: This multicenter study included patients with Crohn\u2019s disease from 3 tertiary hospitals from January 2007 to October 2022. Patients with normal findings on ileocolonoscopy and computed tomography (CT)\/magnetic resonance (MR) enterography but had ulcerations at the small bowel detected by video capsule endoscopy were included. The controls were patients with abnormal findings on endoscopy or CT\/MR enterography. Controls were case-matched in a ratio of 3:1 for sex, calendar year of diagnosis, and age at diagnosis. Results: Among 3,752 patients, 24 (0.6%) were diagnosed with Crohn\u2019s disease using video capsule endoscopy findings. The disease location (P&lt; 0.001) and behavior at diagnosis (P= 0.013) of the cases significantly differed from that of controls. The perianal fistula modifier (25.0% vs. 33.3%, P= 0.446) did not differ significantly between the 2 groups. Initial disease activity and C-reactive protein and fecal calprotectin levels were significantly lower in cases versus controls. The median Lewis score was 838 (interquartile range, 393\u20131,803). Over 10 years of follow-up, the cases showed significantly lower cumulative risk of complicated behavior, biologics use, Crohn\u2019s disease-related hospitalization, and surgeries (log-rank test P&lt; 0.05). Conclusions: Patients with Crohn\u2019s disease whose lesions were observed only by video capsule endoscopy were rare, and exhibit different clinical characteristics and a more favorable long-term disease course compared to those who were conventionally diagnosed.<\/jats:p>","DOI":"10.5217\/ir.2024.00056","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T02:51:24Z","timestamp":1724899884000},"page":"290-301","update-policy":"https:\/\/doi.org\/10.5217\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical characteristics and long-term disease course in patients with Crohn\u2019s disease as diagnosed by video capsule endoscopy: a multicenter retrospective matched case-control study"],"prefix":"10.5217","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-822X","authenticated-orcid":true,"given":"June 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