{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:14:04Z","timestamp":1778120044149,"version":"3.51.4"},"reference-count":12,"publisher":"Korean Association for the Study of Intestinal Diseases","issue":"2","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Takeda Pharmaceutical Company Limited"}],"content-domain":{"domain":["irjournal.org"],"crossmark-restriction":true},"short-container-title":["Intest Res"],"published-print":{"date-parts":[[2026,4,30]]},"abstract":"<jats:p>Background\/Aims: Previous literature suggests that the response of patients with ulcerative colitis to vedolizumab may be affected by previous biologic therapy exposure. This real-world study evaluated vedolizumab treatment effectiveness in biologicnon-na\u00efve patients. Methods: This was a multicenter, retrospective, observational chart review of records from 16 hospitals in Japan (December 1, 2018, to February 29, 2020). Included patients who had ulcerative colitis, were aged \u2265 20 years, and received at least 1 dose of vedolizumab. Outcomes included clinical remission rates from weeks 2 to 54 according to prior biologic exposure status and factors associated with clinical remission up to week 54. Results: A total of 370 eligible patients were included. Clinical remission rates were significantly higher in biologic-na\u00efve (n=197) than in biologic-non-na\u00efve (n=173) patients for weeks 2 to 54 of vedolizumab treatment. Higher clinical remission rates up to week 54 were significantly associated with lower disease severity (partial Mayo score \u2264 4, &lt;i&gt;P&lt;\/i&gt;= 0.001; albumin \u2265 3.0, &lt;i&gt;P&lt;\/i&gt;= 0.019) and the duration of prior anti-tumor necrosis factor \u03b1 (anti-TNF\u03b1) therapy (&lt;i&gt;P&lt;\/i&gt;= 0.026). Patients with anti-TNF\u03b1 therapy durations of &lt; 3 months, 3 to &lt; 12 months, and \u2265 12 months had clinical remission rates of 28.1%, 32.7%, and 60.0%, respectively (&lt;i&gt;P&lt;\/i&gt;= 0.001 across groups). Conclusions: The effectiveness of vedolizumab in biologic-non-na\u00efve patients was significantly influenced by duration of prior anti-TNF\u03b1 therapy. (Japanese Registry of Clinical Trials: jRCT-1080225363)<\/jats:p>","DOI":"10.5217\/ir.2024.00126","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:26:35Z","timestamp":1748996795000},"page":"281-292","update-policy":"https:\/\/doi.org\/10.5217\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The duration of prior anti-tumor necrosis factor agents is associated with the effectiveness of vedolizumab in patients with ulcerative colitis: a real-world multicenter retrospective study"],"prefix":"10.5217","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2073-4234","authenticated-orcid":true,"given":"Taku","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1178-3536","authenticated-orcid":true,"given":"Tadakazu","family":"Hisamatsu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-8493","authenticated-orcid":true,"given":"Satoshi","family":"Motoya","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center, Sapporo-Kosei General Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9590-2370","authenticated-orcid":true,"given":"Minoru","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3048-7270","authenticated-orcid":true,"given":"Toshimitsu","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3083-9600","authenticated-orcid":true,"given":"Reiko","family":"Kunisaki","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center, Yokohama City University Medical Center, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3558-7123","authenticated-orcid":true,"given":"Tomoyoshi","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, 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