{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:14:02Z","timestamp":1778120042287,"version":"3.51.4"},"reference-count":30,"publisher":"Korean Association for the Study of Intestinal Diseases","issue":"2","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["irjournal.org"],"crossmark-restriction":true},"short-container-title":["Intest Res"],"published-print":{"date-parts":[[2026,4,30]]},"abstract":"<jats:p>Background\/Aims: Pouchitis is a common complication in patients with ulcerative colitis (UC) following colectomy with ileal pouch-anal anastomosis (IPAA). Recent studies have identified a novel autoantibody against integrin \u03b1v\u03b26 in patients with UC, correlated with disease activity. This study aimed to assess the association between serum anti-integrin \u03b1v\u03b26 antibody levels and pouch inflammation in patients with postoperative UC. Methods: Serum anti-integrin \u03b1v\u03b26 antibodies were measured using enzyme-linked immunosorbent assay in patients after IPAA, patients with UC, and controls. Results: We examined sera from 71 subjects, including 28 patients who underwent IPAA, 23 controls, and 20 patients with mild and moderate-to-severe UC. Post-IPAA, patients with UC had higher median anti-integrin \u03b1v\u03b26 levels than that of controls (&lt;i&gt;P&lt;\/i&gt;&lt;0.001) but lower than that of patients with active UC (&lt;i&gt;P&lt;\/i&gt;=0.001). Patients with pouchitis had higher antibody levels than those without (&lt;i&gt;P&lt;\/i&gt;=0.047). The receiver operating characteristics curve for anti-integrin \u03b1v\u03b26 showed an area under the curve of 0.724. The pouchitis activity index endoscopic sub-score was correlated with antibody levels (&lt;i&gt;r&lt;\/i&gt;= 0.48, &lt;i&gt;P&lt;\/i&gt;=0.011). Conclusions: Serum anti-integrin \u03b1v\u03b26 antibody levels remain elevated in patients with UC even after total colectomy, and were significantly higher in patients with pouchitis than in those without. This antibody could be a novel and useful biomarker for the diagnosis of pouchitis and assessment of disease activity.<\/jats:p>","DOI":"10.5217\/ir.2024.00170","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T19:23:33Z","timestamp":1745954613000},"page":"248-254","update-policy":"https:\/\/doi.org\/10.5217\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti-integrin \u03b1v\u03b26 autoantibody in patients with ulcerative colitis after proctocolectomy: a cross-sectional study in Japan"],"prefix":"10.5217","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2646-737X","authenticated-orcid":true,"given":"Tsuyoshi","family":"Yanagida","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8808-5672","authenticated-orcid":true,"given":"Shuhei","family":"Hosomi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8728-8101","authenticated-orcid":true,"given":"Hirotsugu","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9692-0420","authenticated-orcid":true,"given":"Masaki","family":"Ominami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, 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