{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:48:29Z","timestamp":1790707709483,"version":"4.1.0"},"reference-count":29,"publisher":"Korean Association for the Study of Intestinal Diseases","issue":"2","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["irjournal.org"],"crossmark-restriction":true},"short-container-title":["Intest Res"],"published-print":{"date-parts":[[2026,4,30]]},"abstract":"<jats:p>Background\/Aims: Real-world data on the use of filgotinib (FILGO) in patients with ulcerative colitis (UC) are limited. This study aims to provide consistent results on the effectiveness and safety of FILGO in treating UC. Methods: A retrospective assessment of clinical and endoscopic activity was conducted in a cohort of patients with UC according to the full Mayo score. The primary co-endpoints of the study were the evaluation of the effectiveness and safety of FILGO. Results: We enrolled 102 patients with a median follow-up of 24 weeks (interquartile range, 8\u201324 weeks). At 8 weeks and the end of follow-up, clinical remission was achieved by 38 (37.2%) and 47 (46.1%) patients, respectively. Clinical remission was achieved in 13 of 18 patients (72.2%) receiving first-line therapy, 7 of 19 patients (36.8%) receiving second-line therapy, and 27 of 65 patients (41.5%) receiving third-line therapy (P= 0.002). Clinical remission at 8 weeks predicted clinical remission at the end of follow-up (P= 0.021). Age &gt; 40 years (P= 0.046) and being on second- or third-line of treatment (P= 0.005) were negative predictors for clinical remission. Seventy-one patients (69.6%) achieved a clinical response. At endoscopic evaluation, mucosal healing was observed in 18 out of 30 patients (60.0%). Steroid-free remission was present in 38 out of 46 patients (82.6%). Five patients (4.9%) needed colectomy. Adverse events were recorded in 6 patients (5.8%): 2 cases (2%) were severe, requiring discontinuation of FILGO.Conclusions: Our real-world data confirms that FILGO is safe and effective for patients with UC. Its efficacy is significantly improved when used as a first-line treatment.<\/jats:p>","DOI":"10.5217\/ir.2025.00067","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T07:47:41Z","timestamp":1759132061000},"page":"341-351","update-policy":"https:\/\/doi.org\/10.5217\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Filgotinib effectiveness and safety as second or third-line therapy in patients with ulcerative colitis: data from a real-world study"],"prefix":"10.5217","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5767-5541","authenticated-orcid":true,"given":"Antonio","family":"Tursi","sequence":"first","affiliation":[{"name":"Territorial Gastroenterology Service, ASL BAT, Andria, Italy"},{"name":"Department of Medical and Surgical Sciences, Catholic University, School of Medicine, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-7409","authenticated-orcid":true,"given":"Giammarco","family":"Mocci","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, AORN \u201cBrotzu\u201d Hospital, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6463-7412","authenticated-orcid":true,"given":"Francesco","family":"Costa","sequence":"additional","affiliation":[{"name":"IBD Unit, Department of General Surgery and Gastroenterology, Pisa University Hospital, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6480-5778","authenticated-orcid":true,"given":"Linda","family":"Ceccarelli","sequence":"additional","affiliation":[{"name":"IBD Unit, Department of General Surgery and Gastroenterology, Pisa University Hospital, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3187-2894","authenticated-orcid":true,"given":"Edoardo","family":"Savarino","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Azienda Ospedale-Universit\u00e0 di Padova (AOUP), Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6120-5936","authenticated-orcid":true,"given":"Caterina","family":"De Barba","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Azienda Ospedale-Universit\u00e0 di Padova (AOUP), Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1457-8738","authenticated-orcid":true,"given":"Caterina","family":"Mucherino","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Azienda Ospedaliera \u201cS. 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