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This rising prevalence, along with the observed differences in clinical characteristics compared to Western populations, underscores the need for region-specific, evidence-based guidance. The Korean Association for the Study of Intestinal Diseases (KASID) established a task force to develop these clinical practice guidelines to optimize the diagnosis and medical management of acute colonic diverticulitis tailored to the Korean healthcare environment. These guidelines were developed through a systematic literature review, critical appraisal of evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology, and expert consensus via a modified Delphi method. They addressed 12 clinical questions encompassing prognostic factors, diagnostic modalities, initial management for uncomplicated diverticulitis, management of complications, and prevention of recurrence. The resulting recommendations provide clinicians with evidence-based guidance for individualized management based on patients\u2019 condition and values. These guidelines aim to enhance the quality of care and optimize outcomes for patients with acute colonic diverticulitis in Korea.<\/jats:p>","DOI":"10.5217\/ir.2025.00299","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T01:42:04Z","timestamp":1780882924000},"page":"428-463","update-policy":"https:\/\/doi.org\/10.5217\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evidence-based clinical practice guidelines for diagnosis and medical management of acute colonic diverticulitis developed by the Korean Association for the Study of Intestinal Diseases (KASID)"],"prefix":"10.5217","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2930-8159","authenticated-orcid":true,"given":"Jae Gon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, 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