{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T06:34:05Z","timestamp":1772519645050,"version":"3.50.1"},"reference-count":0,"publisher":"Surgical Technology Online","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surg Technol Int."],"published-print":{"date-parts":[[2023,12,29]]},"abstract":"<jats:p>Background: Vasoplegic syndrome is a form of vasodilatory shock that can occur before, during or after cardiopulmonary bypass (CPB). We introduce a strategy to reduce the incidence of early hypotension phenomena during Coronary Artery Bypass Graft (CABG) procedures. Materials and Methods: In this prospective cohort study, 100 patients underwent elective CABG with two perioperative CPB settings. The study group (50 patients) was managed with retrograde autologous priming (RAP), 3-minute stepwise for the institution of CPB, and pulsatile flow (PP). The control group (50 patients) was managed without RAP, with the rapid initiation of CPB, and non-pulsatile (NP) flow. The primary endpoints were MAP (mmHg), number of hypotensive phenomena (MAP &lt; 50 mmHg for &gt; 30 sec), the venous return volume on CPB (ml), the cardiac index (L\/min\/m2), hemoglobin (g\/dL), indexed oxygen delivery (DO2i, ml\/min\/m2), the systemic vascular resistance index (SVRI, dynes s m2\/cm5), number of 1-ml boluses of a vasoactive substance (norepinephrine), the positive fluid balance (ml), and the number of red blood cell units for transfusion.  Results: During CPB, the mean values in the study and control groups were as follows: MAP, 68\u00b1 7 vs 56 \u00b1 7 (p-value, 0.0019); hypotensive phenomena, 3 \u00b1 1 vs 8 \u00b12 (p-value, 0.019); venous return volume, 840\u00b179 vs 1129 \u00b1123 (p-value, 0.0017); cardiac index, 2.4 \u00b1 0.4 vs 2.7 \u00b10.2 (p-value, 0.0023); hemoglobin, 9.13 \u00b1 0.29 vs 7.8\u00b1 0.23 (p-value, 0.0001); DO2i, 301\u00b1 12 vs 276\u00b123 (p-value, 0.0011); SVRI, 1879 \u00b1280 vs 2210 \u00b1140 (p-value, 0.0017); norepinephrine, 1\u00b12 vs 8 \u00b13 (p-value, 0.0023); positive fluid balance, 750 \u00b1212 vs 1450 \u00b1220 (p-value, 0.005); and total number of red blood cell units for transfusion, 16 \u00b14.2 vs 27 \u00b1 5.3 (p-value, 0.008).  Conclusions: In this prospective cohort study, during CPB, the study group showed a better preservation of MAP, SVRI, and DO2i, and a reduction of vasoconstrictor use in a CPB setting with the RAP technique, 3-minute stepwise for the initiation of CPB and pulsatile pump flow, compared to the control group. Further studies are needed to validate this perioperative approach to CPB.<\/jats:p>","DOI":"10.52198\/23.sti.43.cv1727","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T15:52:51Z","timestamp":1706197971000},"source":"Crossref","is-referenced-by-count":2,"title":["Cardiopulmonary Bypass Settings for  the Prevention of Early Hypotension  During CABG"],"prefix":"10.52198","volume":"43","author":[{"name":"Department of Cardiac Surgery, Anthea Hospital, GVM Care & Research, Bari, Italy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Nasso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Speziale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Cardiac Surgery, Anthea Hospital, GVM Care & Research, Bari, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bartolomucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Ospedale Lorenzo Bonomo, ASL BAT, Andria, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovani","family":"Valenti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Ospedale Lorenzo Bonomo, ASL BAT, Andria, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Larosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Ospedale Lorenzo Bonomo, ASL BAT, Andria, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Borrello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Division of Cardiology and Intensive Care Unit, Pugliese-Ciaccio Hospital, Catanzaro, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Amodeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Cardiology, Ospedale Santa Maria degli Ungheresi, Polistena, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Fiore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Cardiac Surgery, Anthea Hospital, GVM Care & Research, Bari, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignazio","family":"Condello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Cardiac Surgery, Anthea Hospital, GVM Care & Research, Bari, Italy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18996","container-title":["Surgical Technology Online"],"original-title":[],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T15:52:53Z","timestamp":1706197973000},"score":1,"resource":{"primary":{"URL":"https:\/\/surgicaltechnology.com\/43-Cardiovascular-Surgery.htm#1727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.52198\/23.sti.43.cv1727","relation":{},"ISSN":["1090-3941","1090-3941"],"issn-type":[{"value":"1090-3941","type":"print"},{"value":"1090-3941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,29]]}}}