{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:44:25Z","timestamp":1783604665798,"version":"3.55.0"},"reference-count":0,"publisher":"Narra Sains Indonesia","issue":"1","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Narra J"],"abstract":"<jats:p>Recent studies have demonstrated that cytokine dysregulation has a critical role in the pathogenesis of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). The aim of this study was to investigate the association between tumor necrosis factor (TNF-\u03b1), interleukin 6 (IL-6), interleukin 10 (IL-10), and interleukin 17 (IL-17) with infection status, and severity of dengue. A prospective cross-sectional study was conducted at three hospitals in Gianyar regency and Denpasar municipality, Bali, Indonesia, from June to December 2022. Sixty-four dengue infected patients were involved. Patients\u2019 serum was tested for dengue infection using NS1 antigen rapid test, dengue virus immunoglobulin M (IgM) and immunoglobulin G (IgG) test, and reverse transcription polymerase chain reaction (RT-PCR). Cytokine levels (TNF-\u03b1, IL-6, IL-10, and IL-17) were measured using enzyme-linked immunosorbent assay (ELISA). Infection status was determined by combining serological and RT-PCR results, categorizing patients into primary and secondary infections. The present study found that DF patients had lower TNF-\u03b1, IL-6, and IL-17 but higher IL-10 levels compared to DHF patients (p&lt;0.001). Elevated TNF-\u03b1, IL-6, and IL-17 levels were higher in secondary infection, while IL-10 level was higher in primary infection (p&lt;0.001). In conclusion, cytokines play a crucial role in the interplay between cytokine dysregulation and dengue infection dynamics.<\/jats:p>","DOI":"10.52225\/narra.v4i1.309","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T03:19:41Z","timestamp":1709867981000},"page":"e309","source":"Crossref","is-referenced-by-count":23,"title":["Cytokine profiles in dengue fever and dengue hemorrhagic fever: A study from Indonesia"],"prefix":"10.52225","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1170-1841","authenticated-orcid":false,"given":"Sri","family":"Masyeni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Made W.","family":"Wardhana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0989-4023","authenticated-orcid":false,"given":"Firzan","family":"Nainu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"29794","published-online":{"date-parts":[[2024,3,8]]},"container-title":["Narra J"],"original-title":[],"link":[{"URL":"https:\/\/narraj.org\/main\/article\/download\/309\/293","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/narraj.org\/main\/article\/download\/309\/293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T03:25:43Z","timestamp":1710300343000},"score":1,"resource":{"primary":{"URL":"https:\/\/narraj.org\/main\/article\/view\/309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,8]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,1]]}},"URL":"https:\/\/doi.org\/10.52225\/narra.v4i1.309","relation":{},"ISSN":["2807-2618"],"issn-type":[{"value":"2807-2618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,8]]}}}