{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T13:14:53Z","timestamp":1747228493747,"version":"3.40.5"},"reference-count":0,"publisher":"Narra Sains Indonesia","issue":"2","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Narra J"],"abstract":"<jats:p>Heart failure is a pediatric emergency caused by the heart's inability to adequately meet the body metabolic needs and the most common cause is congenital heart disease (CHD). The G protein is the most prominent family of membrane-bound protein known to act in major regulatory events of the cardiovascular system, one of which is heart failure. The aim of this study was to determine the level of G protein and its relationship with left ventricular systolic function in children with acyanotic CHD. A cross-sectional study was conducted in Dr. Zaionel Abidin Hospital, Banda Aceh, Indonesia. The patients aged 0 to 18 years and had acyanotic CHD diagnosis by echocardiography were included. Anthropometry measurement was performed according to standard WHO procedures and G protein level was measured using the ELISA method. The Chi-squared test was used to measure the relationship between G protein level and left ventricular systolic function. Out of a total of 38 children with acyanotic CHD, the mean level of G protein was 36.25 ng\/mL and the mean of left ventricular systolic function was 73.1%. There was no relationship between G protein and left ventricular systolic function in children with acyanotic CHD. However, further study with a larger sample size and considering other variables are needed to confirm this finding.<\/jats:p>","DOI":"10.52225\/narra.v4i2.531","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T04:27:18Z","timestamp":1715228838000},"page":"e531","source":"Crossref","is-referenced-by-count":0,"title":["Relationship between G protein level with left ventricular systolic function in children with acyanotic heart disease"],"prefix":"10.52225","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3553-2301","authenticated-orcid":false,"given":"Herlina","family":"Dimiati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mira","family":"Srikandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6090-4402","authenticated-orcid":false,"given":"Te","family":"Haypheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7258-9913","authenticated-orcid":false,"given":"Nora","family":"Sovira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heru N.","family":"Herdata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bakhtiar","family":"Bakhtiar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eka D.","family":"Edward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"29794","published-online":{"date-parts":[[2024,5,9]]},"container-title":["Narra J"],"original-title":[],"link":[{"URL":"https:\/\/www.narraj.org\/main\/article\/download\/531\/353","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.narraj.org\/main\/article\/download\/531\/353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T04:31:48Z","timestamp":1715488308000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.narraj.org\/main\/article\/view\/531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,9]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,4,17]]}},"URL":"https:\/\/doi.org\/10.52225\/narra.v4i2.531","relation":{},"ISSN":["2807-2618"],"issn-type":[{"type":"electronic","value":"2807-2618"}],"subject":[],"published":{"date-parts":[[2024,5,9]]}}}