{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:18:22Z","timestamp":1774415902375,"version":"3.50.1"},"reference-count":0,"publisher":"Narra Sains Indonesia","issue":"3","license":[{"start":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T00:00:00Z","timestamp":1729382400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Narra J"],"abstract":"<jats:p>A worldwide issue, vitamin D deficiency affects pregnant mothers and babies everywhere, including Indonesia. It involves the adaptive immune system by controlling the production of pro- and anti-inflammatory cytokines and the balance between humoral (Th2) and cell-mediated (Th1) immunity. The aim of this study was to investigate the relationship between vitamin D and the cytokines IL-6 and IL-10 in infants. It also examined the relationship between ferritin and IL-6\/IL-10 in newborns. The study collected 114 umbilical cord blood samples from term-born mothers without clinical symptoms. IL-6 and IL-10 were among the cytokine profiles measured by the enzyme-linked immunosorbent assay (ELISA). SPSS was used for statistical analysis, and an in-silico investigation was carried out to examine the molecular relationships between vitamin D and IL-6\/IL-10. Using the 20 ng\/mL as the cut-off for vitamin D insufficiency suggested the insignificant association of vitamin D with IL-6 (p=0.42), IL-10 (p=0.76), and\u00a0ferritin (p=0.47). When the umbilical cord vitamin D level was categorized into four quartiles, the association with the highest statistical significance (quartile 4 versus quartile 2) was observed for IL-6 (p&lt;0.001), IL-10 (p&lt;0.001), and ferritin (p&lt;0.001). However, the linear regression did not suggest the significant correlations of vitamin D with IL-6 (p=0.40) and IL-10 (p=0.45). A significant correlation based on the linear regression was found between ferritin and IL-10 (p=0.03). Molecular docking studies demonstrated binding affinities of -8.04 kcal\/mol for IL-6-vitamin D and -8.53 kcal\/mol for IL-10-vitamin D complexes, with stable root mean square deviation throughout the simulations. This study contributes valuable insights into the clinical and computational analysis of the relationship of vitamin D with IL-6 or IL-10.<\/jats:p>","DOI":"10.52225\/narra.v4i3.889","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T13:01:28Z","timestamp":1729602088000},"page":"e889","source":"Crossref","is-referenced-by-count":4,"title":["Association between vitamin D levels with IL-6 and IL-10 in umbilical cord blood of infants"],"prefix":"10.52225","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3347-6529","authenticated-orcid":false,"given":"Muhammad N.","family":"Massi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahrul","family":"Fikri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azwin M.","family":"Putera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5419-8938","authenticated-orcid":false,"given":"Sofa D.","family":"Alfian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadira R.","family":"Ridha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8034-3410","authenticated-orcid":false,"given":"Sri H.","family":"Putri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ummi","family":"Chaera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9079-4147","authenticated-orcid":false,"given":"Israini W.","family":"Iskandar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8076-0493","authenticated-orcid":false,"given":"Naoki","family":"Shimojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"29794","published-online":{"date-parts":[[2024,10,20]]},"container-title":["Narra J"],"original-title":[],"link":[{"URL":"https:\/\/narraj.org\/main\/article\/download\/889\/514","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/narraj.org\/main\/article\/download\/889\/514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T13:01:29Z","timestamp":1729602089000},"score":1,"resource":{"primary":{"URL":"https:\/\/narraj.org\/main\/article\/view\/889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,20]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,8,27]]}},"URL":"https:\/\/doi.org\/10.52225\/narra.v4i3.889","relation":{},"ISSN":["2807-2618"],"issn-type":[{"value":"2807-2618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,20]]}}}