{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T07:44:56Z","timestamp":1770795896135,"version":"3.50.0"},"reference-count":0,"publisher":"Narra Sains Indonesia","issue":"1","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Narra J"],"abstract":"<jats:p>Preeclampsia (PE) is a complication of pregnancy with high morbidity and mortality, characterized by endothelial dysfunction, systemic inflammation, and impaired renal function. Interleukin-6 (IL-6) and serum creatinine have potential as biomarkers for early detection of PE; however, data from Indonesia are limited. The aim of this study was to compare IL-6 and serum creatinine levels between pregnant women with PE and normotensive controls, as well as their diagnostic performance in identifying PE. A cross-sectional study involving pregnant women with PE and normotensive controls was conducted at Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia. Serum IL-6 and creatinine levels were measured using the ECLIA method. Levels were compared using the Mann\u2013Whitney test; diagnostic performance was assessed using receiver operating characteristic (ROC) curve analysis, and multivariable logistic regression was used to evaluate combined diagnostic contribution. A total of 68 pregnant women were included, comprising 34 patients with PE and 34 normotensive controls. Median IL-6 levels were significantly higher in the PE group (16.05 pg\/mL) than in the control group (3.71 pg\/mL). Receiver operating characteristic analysis demonstrated excellent diagnostic performance of IL-6, with an are under the curve (AUC) of 0.831 (95%CI: 0.734\u20130.929). At an optimal cutoff value of 5.52 pg\/mL, IL-6 achieved a sensitivity of 73.53%, specificity of 76.47%, and diagnostic accuracy of 86.76%. Median serum creatinine levels were also significantly elevated in the PE group (0.56 mg\/dL) compared with controls (0.44 mg\/dL;\u00a0p&lt;0.001). The AUC for serum creatinine was 0.806 (95%CI: 0.700\u20130.912), indicating good diagnostic performance. At a cutoff value of 0.475 mg\/dL, serum creatinine demonstrated a sensitivity of 70.59%, specificity of 73.53%, and accuracy of 72.06%. Multivariable logistic regression confirmed that IL-6 (B=0.123;\u00a0p=0.005) and serum creatinine (B=9.306;\u00a0p=0.023) were independently associated with PE, explaining 57.5% of PE variability (Nagelkerke R\u00b2=0.575). These findings indicate that serum IL-6 and creatinine are significantly associated with PE, and their combined assessment shows potential as a predictive biomarker with good diagnostic performance.<\/jats:p>","DOI":"10.52225\/narra.v6i1.3016","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T02:46:47Z","timestamp":1770778007000},"page":"e3016","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of interleukin-6 and serum creatinine levels in preeclampsia and normal pregnancy patients: A cross-sectional study in Indonesia"],"prefix":"10.52225","volume":"6","author":[{"given":"Syerli R.","family":"Dewi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6010-9791","authenticated-orcid":false,"given":"Cut M.","family":"Yeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7328-965X","authenticated-orcid":false,"given":"Munizar","family":"Munizar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tgk. Puspa","family":"Dewi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niken A.","family":"Utami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rusnaidi","family":"Rusnaidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"29794","published-online":{"date-parts":[[2026,2,10]]},"container-title":["Narra J"],"original-title":[],"link":[{"URL":"https:\/\/narraj.org\/main\/article\/download\/3016\/916","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/narraj.org\/main\/article\/download\/3016\/916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T02:46:47Z","timestamp":1770778007000},"score":1,"resource":{"primary":{"URL":"https:\/\/narraj.org\/main\/article\/view\/3016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,10]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,13]]}},"URL":"https:\/\/doi.org\/10.52225\/narra.v6i1.3016","relation":{},"ISSN":["2807-2618"],"issn-type":[{"value":"2807-2618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,10]]}}}