{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:05:28Z","timestamp":1785312328539,"version":"3.55.0"},"reference-count":0,"publisher":"Narra Sains Indonesia","issue":"2","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Narra J"],"abstract":"<jats:p>Rheumatoid arthritis (RA) is associated with accelerated bone loss, partly mediated by dysregulation of the receptor activator of nuclear factor-\u03baB (RANK)\/RANK ligand (RANKL)\/osteoprotegerin (OPG) pathway, which regulates osteoclast activity. Carboxy-terminal cross-linked telopeptide of type I collagen (CTX-1) is a biochemical marker of bone resorption and may reflect increased skeletal turnover in RA. Although previous studies have evaluated RANKL, OPG, and the RANKL\/OPG ratio in relation to bone mineral density, osteoporosis, and fracture risk, the correlations of circulating RANK, RANKL, and OPG with CTX-1 remain insufficiently characterized in patients with RA. The aim of this study was to evaluate the correlations of serum RANK, RANKL, and OPG levels with serum CTX-1 levels in patients with RA. An analytical cross-sectional study was conducted at a provincial referral hospital in Padang, Indonesia, from July to December 2024, during which patients with RA were recruited through consecutive sampling. Serum RANK, RANKL, OPG, and CTX-1 concentrations were measured using enzyme-linked immunosorbent assays. Correlations were assessed using Pearson\u2019s correlation analysis. The mean age of the patients was 40.30\u00b15.08 years. The mean serum concentrations of RANK, RANKL, OPG, and CTX-1 were 5.20\u00b12.83, 6.55\u00b13.14, 0.17\u00b10.09, and 2.10\u00b11.10 ng\/mL, respectively. Serum RANK and RANKL levels showed very strong positive correlations with CTX-1 levels (r=0.928 and r=0.929, respectively; both p&lt;0.001). Serum OPG levels also showed a strong positive correlation with CTX-1 levels (r=0.786; p&lt;0.001). These findings suggest that circulating components of the RANK\/RANKL\/OPG pathway are associated with biochemical bone resorption in patients with RA. However, a larger longitudinal study incorporating disease activity, treatment exposure and bone mineral density is required to determine their clinical relevance.<\/jats:p>","DOI":"10.52225\/narra.v6i2.2831","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T07:30:16Z","timestamp":1785310216000},"page":"e2831","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between serum bone remodeling biomarkers and CTX-1 levels among patients with rheumatoid arthritis: A cross-sectional study at a provincial referral hospital in Indonesia"],"prefix":"10.52225","volume":"6","author":[{"given":"Najirman","family":"Najirman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eka","family":"Kurniawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herdian","family":"Herdian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"29794","published-online":{"date-parts":[[2026,7,27]]},"container-title":["Narra J"],"original-title":[],"link":[{"URL":"https:\/\/narraj.org\/main\/article\/download\/2831\/955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/narraj.org\/main\/article\/download\/2831\/955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T07:30:16Z","timestamp":1785310216000},"score":1,"resource":{"primary":{"URL":"https:\/\/narraj.org\/main\/article\/view\/2831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,5,4]]}},"URL":"https:\/\/doi.org\/10.52225\/narra.v6i2.2831","relation":{},"ISSN":["2807-2618"],"issn-type":[{"value":"2807-2618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]}}}