{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:19:52Z","timestamp":1785428392942,"version":"3.56.0"},"reference-count":100,"publisher":"Organization for Human Brain Mapping","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Cognitive and physical function are interrelated in aging. Co-occurring impairments in both domains can be debilitating and lead to increased risk of developing dementia. Amyloid beta (A\u03b2) deposition in the brain is linked to cognitive decline and is also associated with poorer physical function in older adults. However, significant inter-individual variability exists with respect to the influence of increased brain A\u03b2 concentrations on cognitive and physical outcomes. Identifying factors that explain inter-individual variability in associations between A\u03b2 and clinical outcomes could inform interventions designed to delay declines in both cognitive and physical function. Cognitive reserve (CR) is considered a buffer that allows for cognitive performance that is better than expected for a given level of brain injury or pathology. Although the neural mechanisms underlying CR remain unknown, there is growing evidence that resting-state brain networks may serve as a neural surrogate for CR. The current study utilized a statistical interaction model to evaluate if functional brain networks moderated associations between brain A\u03b2 and cognitive and physical function in community-dwelling older adults from the Brain Networks and Mobility (B-NET) study. Significant moderations were found between A\u03b2 levels and both the central executive and subcortical networks with cognitive and physical function. The findings suggest that brain networks serve as a buffer against the influence of A\u03b2 accumulation on cognitive and physical function indicating that the network integrity could one of the neural mechanisms supporting CR.<\/jats:p>","DOI":"10.52294\/001c.141046","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T14:41:18Z","timestamp":1753195278000},"source":"Crossref","is-referenced-by-count":1,"title":["Moderation between resting-state connectivity and brain amyloid levels on speed of cognitive and physical function in older adults: Evidence for network-based cognitive reserve"],"prefix":"10.52294","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8871-9658","authenticated-orcid":true,"given":"Paul J.","family":"Laurienti","sequence":"first","affiliation":[{"name":"Wake Forest University School of Medicine","department":["Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Kritchevsky","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine","department":["Sticht Center for Healthy Aging and Alzheimer\u2019s Prevention, Department of Internal Medicine Section on Gerontology and Geriatric Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Lyday","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine","department":["Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chal E.","family":"Tomlinson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03qd7mz70","id-type":"ROR","asserted-by":"publisher"}],"name":"Johnson & Johnson (United States)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Miller","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine","department":["Division of Public Health Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel N.","family":"Lockhart","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine","department":["Sticht Center for Healthy Aging and Alzheimer\u2019s Prevention, Department of Internal Medicine Section on Gerontology and Geriatric Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa M.","family":"Rundle","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine","department":["Sticht Center for Healthy Aging and Alzheimer\u2019s Prevention, Department of Internal Medicine Section on Gerontology and Geriatric Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina E.","family":"Hugenschmidt","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine","department":["Sticht Center for Healthy Aging and Alzheimer\u2019s Prevention, Department of Internal Medicine Section on Gerontology and Geriatric Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Burdette","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine","department":["Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M.","family":"Shappell","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine","department":["Department of Biostatistics and Data Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Chen","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine","department":["Department of Biostatistics and Data Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura D.","family":"Baker","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine","department":["Sticht Center for Healthy Aging and Alzheimer\u2019s Prevention, Department of Internal Medicine Section on Gerontology and Geriatric Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake R.","family":"Neyland","sequence":"additional","affiliation":[{"name":"LifeSci Consulting"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roee","family":"Holtzer","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05cf8a891","id-type":"ROR","asserted-by":"publisher"}],"name":"Albert Einstein College of Medicine","department":["Department of Neurology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"29889","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"publisher","first-page":"3969","DOI":"10.1093\/brain\/awad159","article-title":"The amyloid cascade hypothesis: an updated critical review","volume":"146","author":"K. 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