{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:43:25Z","timestamp":1787031805138,"version":"build-2736575974"},"reference-count":68,"publisher":"XMLink","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["jgc-online.org"],"crossmark-restriction":false},"short-container-title":["J Gastric Cancer"],"published-print":{"date-parts":[[2026]]},"DOI":"10.5230\/jgc.2026.26.e10","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T23:30:18Z","timestamp":1767569418000},"page":"127","update-policy":"https:\/\/doi.org\/10.5230\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["CLDN18.2 in Gastric Cancer: Current Therapeutic Landscape and Future Perspectives"],"prefix":"10.5230","volume":"26","author":[{"given":"Fei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4097-6120","authenticated-orcid":false,"given":"Ukyo","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4987-1934","authenticated-orcid":false,"given":"Izuma","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5196-3630","authenticated-orcid":false,"given":"Kohei","family":"Shitara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18617","reference":[{"key":"10.5230\/jgc.2026.26.e10_ref1","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/S0140-6736(25)00052-2","volume":"405","author":"Sundar","year":"2025","journal-title":"Lancet"},{"key":"10.5230\/jgc.2026.26.e10_ref2","first-page":"10","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J Clin"},{"key":"10.5230\/jgc.2026.26.e10_ref3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0140-6736(21)00797-2","volume":"398","author":"Janjigian","year":"2021","journal-title":"Lancet"},{"key":"10.5230\/jgc.2026.26.e10_ref4","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/S1470-2045(23)00515-6","volume":"24","author":"Rha","year":"2023","journal-title":"Lancet Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref5","doi-asserted-by":"crossref","first-page":"e078876","DOI":"10.1136\/bmj-2023-078876","volume":"385","author":"Qiu","year":"2024","journal-title":"BMJ"},{"key":"10.5230\/jgc.2026.26.e10_ref6","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0140-6736(23)02033-0","volume":"402","author":"Janjigian","year":"2023","journal-title":"Lancet"},{"key":"10.5230\/jgc.2026.26.e10_ref7","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1056\/NEJMc2408121","volume":"391","author":"Janjigian","year":"2024","journal-title":"N Engl J Med"},{"key":"10.5230\/jgc.2026.26.e10_ref8","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.21037\/tcr-19-1876","volume":"9","author":"Hong","year":"2020","journal-title":"Transl Cancer Res"},{"key":"10.5230\/jgc.2026.26.e10_ref9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13045-017-0473-4","volume":"10","author":"Singh","year":"2017","journal-title":"J Hematol Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref10","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0140-6736(23)00620-7","volume":"401","author":"Shitara","year":"2023","journal-title":"Lancet"},{"key":"10.5230\/jgc.2026.26.e10_ref11","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1038\/s41591-023-02465-7","volume":"29","author":"Shah","year":"2023","journal-title":"Nat Med"},{"key":"10.5230\/jgc.2026.26.e10_ref12","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1056\/NEJMc2409512","volume":"391","author":"Shitara","year":"2024","journal-title":"N Engl J Med"},{"key":"10.5230\/jgc.2026.26.e10_ref13","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1200\/JCO.2025.43.16_suppl.4032","volume":"43","author":"Gong","year":"2025","journal-title":"J Clin Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref14","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.clon.2023.02.007","volume":"41","author":"Wang","year":"2023","journal-title":"J Clin Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S1470-2045(24)00636-3","volume":"26","author":"Ruan","year":"2025","journal-title":"Lancet Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref16","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1016\/S0140-6736(25)00860-8","volume":"405","author":"Qi","year":"2025","journal-title":"Lancet"},{"key":"10.5230\/jgc.2026.26.e10_ref17","doi-asserted-by":"crossref","first-page":"7380","DOI":"10.1128\/MCB.21.21.7380-7390.2001","volume":"21","author":"Niimi","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.5230\/jgc.2026.26.e10_ref18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.gene.2011.04.007","volume":"481","author":"T\u00fcreci","year":"2011","journal-title":"Gene"},{"key":"10.5230\/jgc.2026.26.e10_ref19","doi-asserted-by":"crossref","first-page":"7624","DOI":"10.1158\/1078-0432.CCR-08-1547","volume":"14","author":"Sahin","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.5230\/jgc.2026.26.e10_ref20","doi-asserted-by":"crossref","first-page":"G1106","DOI":"10.1152\/ajpgi.00158.2007","volume":"293","author":"Jovov","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.5230\/jgc.2026.26.e10_ref21","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1053\/j.gastro.2011.10.040","volume":"142","author":"Hayashi","year":"2012","journal-title":"Gastroenterology"},{"key":"10.5230\/jgc.2026.26.e10_ref22","doi-asserted-by":"crossref","first-page":"17588359251344804","DOI":"10.1177\/17588359251344804","volume":"17","author":"Yamamoto","year":"2025","journal-title":"Ther Adv Med Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref23","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/1471-2407-6-186","volume":"6","author":"Hewitt","year":"2006","journal-title":"BMC Cancer"},{"key":"10.5230\/jgc.2026.26.e10_ref24","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.addr.2005.01.006","volume":"57","author":"Swisshelm","year":"2005","journal-title":"Adv Drug Deliv Rev"},{"key":"10.5230\/jgc.2026.26.e10_ref25","doi-asserted-by":"crossref","first-page":"9603","DOI":"10.1158\/0008-5472.CAN-05-2782","volume":"65","author":"Morin","year":"2005","journal-title":"Cancer Res"},{"key":"10.5230\/jgc.2026.26.e10_ref26","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/path.1922","volume":"208","author":"Sanada","year":"2006","journal-title":"J Pathol"},{"key":"10.5230\/jgc.2026.26.e10_ref27","doi-asserted-by":"crossref","first-page":"e74757","DOI":"10.1371\/journal.pone.0074757","volume":"8","author":"Oshima","year":"2013","journal-title":"PLoS One"},{"key":"10.5230\/jgc.2026.26.e10_ref28","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1111\/j.1349-7006.2007.00490.x","volume":"98","author":"Matsuda","year":"2007","journal-title":"Cancer Sci"},{"key":"10.5230\/jgc.2026.26.e10_ref29","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00428-019-02624-7","volume":"475","author":"Dottermusch","year":"2019","journal-title":"Virchows Arch"},{"key":"10.5230\/jgc.2026.26.e10_ref30","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nature13480","volume":"513","author":"Cancer Genome Atlas Research Network","year":"2014","journal-title":"Nature"},{"key":"10.5230\/jgc.2026.26.e10_ref31","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.3389\/fonc.2020.01214","volume":"10","author":"Zhang","year":"2020","journal-title":"Front Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref32","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1111\/cas.13967","volume":"110","author":"Nakayama","year":"2019","journal-title":"Cancer Sci"},{"key":"10.5230\/jgc.2026.26.e10_ref33","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1038\/s41467-018-06747-4","volume":"9","author":"Yang","year":"2018","journal-title":"Nat Commun"},{"key":"10.5230\/jgc.2026.26.e10_ref34","doi-asserted-by":"crossref","first-page":"4779","DOI":"10.1038\/s41388-022-02469-6","volume":"41","author":"Komatsu","year":"2022","journal-title":"Oncogene"},{"key":"10.5230\/jgc.2026.26.e10_ref35","doi-asserted-by":"crossref","first-page":"v126","DOI":"10.1093\/annonc\/mdx367.012","volume":"28","author":"Mitnacht-Kraus","year":"2017","journal-title":"Ann Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref36","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1111\/cas.15684","volume":"114","author":"Shitara","year":"2023","journal-title":"Cancer Sci"},{"key":"10.5230\/jgc.2026.26.e10_ref37","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1093\/annonc\/mdz199","volume":"30","author":"T\u00fcreci","year":"2019","journal-title":"Ann Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref38","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.annonc.2021.02.005","volume":"32","author":"Sahin","year":"2021","journal-title":"Ann Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref39","doi-asserted-by":"crossref","first-page":"5","DOI":"10.5230\/jgc.2025.25.e11","volume":"25","author":"Kim","year":"2025","journal-title":"J Gastric Cancer"},{"key":"10.5230\/jgc.2026.26.e10_ref40","unstructured":"National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology. Gastric cancer. Version 3.2025 [Internet]. Plymouth Meeting (PA). National Comprehensive Cancer Network. 2024. cited 2025 Dec 17. Available from: https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1434"},{"key":"10.5230\/jgc.2026.26.e10_ref41","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1158\/1078-0432.CCR-23-0204","volume":"29","author":"Klempner","year":"2023","journal-title":"Clin Cancer Res"},{"key":"10.5230\/jgc.2026.26.e10_ref42","doi-asserted-by":"crossref","first-page":"TPS504","DOI":"10.1200\/JCO.2025.43.4_suppl.TPS504","volume":"43","author":"Okunaka","year":"2025","journal-title":"J Clin Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref43","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1200\/JCO.2025.43.16_suppl.4044","volume":"43","author":"Zhang","year":"2025","journal-title":"J Clin Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref44","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1200\/JCO.2025.43.4_suppl.454","volume":"43","author":"Peng","year":"2025","journal-title":"J Clin Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref45","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1200\/JCO.2023.41.4_suppl.798","volume":"41","author":"Huang","year":"2023","journal-title":"J Clin Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref46","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1200\/JCO.2023.41.4_suppl.391","volume":"41","author":"Li","year":"2023","journal-title":"J Clin Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref47","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1200\/JCO.2023.41.16_suppl.2537","volume":"41","author":"Sharma","year":"2023","journal-title":"J Clin Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref48","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMoa2004413","volume":"382","author":"Shitara","year":"2020","journal-title":"N Engl J Med"},{"key":"10.5230\/jgc.2026.26.e10_ref49","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0140-6736(19)31774-X","volume":"394","author":"Chau","year":"2019","journal-title":"Lancet"},{"key":"10.5230\/jgc.2026.26.e10_ref50","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41571-021-00470-8","volume":"18","author":"Drago","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref51","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMoa1914510","volume":"382","author":"Modi","year":"2020","journal-title":"N Engl J Med"},{"key":"10.5230\/jgc.2026.26.e10_ref52","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1056\/NEJMoa2115022","volume":"386","author":"Cort\u00e9s","year":"2022","journal-title":"N Engl J Med"},{"key":"10.5230\/jgc.2026.26.e10_ref53","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1038\/s41591-025-03783-8","volume":"31","author":"Liu","year":"2025","journal-title":"Nat Med"},{"key":"10.5230\/jgc.2026.26.e10_ref54","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1038\/s41591-025-03781-w","volume":"31","author":"Ruan","year":"2025","journal-title":"Nat Med"},{"key":"10.5230\/jgc.2026.26.e10_ref55","doi-asserted-by":"crossref","first-page":"S1740","DOI":"10.1016\/j.annonc.2025.09.098","volume":"36","author":"Yu","year":"2025","journal-title":"Ann Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref56","doi-asserted-by":"crossref","first-page":"115808","DOI":"10.1016\/j.ejca.2025.115808","volume":"230","author":"Bai","year":"2025","journal-title":"Eur J Cancer"},{"key":"10.5230\/jgc.2026.26.e10_ref57","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1200\/JCO.2025.43.16_suppl.3034","volume":"43","author":"Yu","year":"2025","journal-title":"J Clin Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref58","unstructured":"Elevation Oncology. Elevation Oncology to discontinue development of EO-3021; advancing EO-1022, while evaluating strategic options [Internet]. Boston (MA). Elevation Oncology. 2025. cited 2025 Nov 9. Available from: https:\/\/www.prnewswire.com\/news-releases\/elevation-oncology-to-discontinue-development-of-eo-3021-advancing-eo-1022-while-evaluating-strategic-options-302406229.html"},{"key":"10.5230\/jgc.2026.26.e10_ref59","doi-asserted-by":"crossref","first-page":"S1202","DOI":"10.1016\/j.annonc.2025.08.2755","volume":"36","author":"Dayyani","year":"2025","journal-title":"Ann Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref60","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1200\/JCO.2024.42.16_suppl.2519","volume":"42","author":"Zheng","year":"2024","journal-title":"J Clin Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref61","doi-asserted-by":"crossref","first-page":"4944","DOI":"10.1158\/1078-0432.CCR-24-4280","volume":"31","author":"Ku","year":"2025","journal-title":"Clin Cancer Res"},{"key":"10.5230\/jgc.2026.26.e10_ref62","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.1016\/j.annonc.2025.05.404","volume":"36","author":"Klempner","year":"2025","journal-title":"Ann Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref63","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1200\/JCO.2024.42.16_suppl.2662","volume":"42","author":"Guo","year":"2024","journal-title":"J Clin Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref64","doi-asserted-by":"crossref","first-page":"S933","DOI":"10.1016\/j.annonc.2024.08.1594","volume":"35","author":"Overman","year":"2024","journal-title":"Ann Oncol"},{"key":"10.5230\/jgc.2026.26.e10_ref65","doi-asserted-by":"crossref","first-page":"e471716","DOI":"10.1200\/EDBK-25-471716","volume":"45","author":"Nakayama","year":"2025","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"10.5230\/jgc.2026.26.e10_ref66","doi-asserted-by":"crossref","first-page":"9651","DOI":"10.1038\/s41467-025-65148-6","volume":"16","author":"Carstens","year":"2025","journal-title":"Nat Commun"},{"key":"10.5230\/jgc.2026.26.e10_ref67","doi-asserted-by":"crossref","first-page":"105805","DOI":"10.1016\/j.esmoop.2025.105805","volume":"10","author":"Yamamoto","year":"2025","journal-title":"ESMO Open"},{"key":"10.5230\/jgc.2026.26.e10_ref68","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/jjco\/hyaf055","volume":"55","author":"Yanagimoto","year":"2025","journal-title":"Jpn J Clin Oncol"}],"container-title":["Journal of Gastric Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jgc-online.org\/pdf\/10.5230\/jgc.2026.26.e10","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jgc-online.org\/DOIx.php?id=10.5230\/jgc.2026.26.e10","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jgc-online.org\/DOIx.php?id=10.5230\/jgc.2026.26.e10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T23:28:19Z","timestamp":1767742099000},"score":1,"resource":{"primary":{"URL":"https:\/\/jgc-online.org\/DOIx.php?id=10.5230\/jgc.2026.26.e10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5230\/jgc.2026.26.e10","relation":{},"ISSN":["2093-582X","2093-5641"],"issn-type":[{"value":"2093-582X","type":"print"},{"value":"2093-5641","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"2025-12-09","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-18","name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-31","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"Copyright \u00a9 2026. Korean Gastric Cancer Association","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https:\/\/creativecommons.org\/licenses\/by-nc\/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}