{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:15:49Z","timestamp":1793834149780,"version":"4.6.1"},"reference-count":49,"publisher":"IMR Press","issue":"7","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Biosci. (Landmark Ed)"],"abstract":"<jats:p>Introduction: Several studies suggest that there is an association between the metastatic nodal tumor volume and the clinical outcome in patients with solid cancers. However, despite the prognostic potential of nodal volume, a standardized method for estimating the nodal volumetric parameters is lacking. Herein, we conducted a systematic review of the published scientific literature towards investigating the prognostic value of nodal volume in the carcinomas of head and neck, taking into consideration the primary tumor site and the human papillomavirus (HPV) status. Methodological issues: For this purpose, the biomedical literature database PubMed\/MEDLINE was searched for studies relevant to the relationship of nodal volume to the treatment outcome and survival in head and neck squamous cell carcinoma (HNSCC) patients. Collectively, based on stringent inclusion\/exclusion criteria, 23 eligible studies were included in the present systematic review. Results: On the basis of our findings, nodal volume is suggested to be strongly associated with clinical outcomes in HNSCC patients. Of particular note, there is an indication that nodal volume is an independent factor for further risk stratification for recurrence-free survival in patients with squamous cell carcinoma of the pharynx (oropharynx and hypopharynx). Extranodal extension (ENE) and HPV status should be also taken into consideration in further studies.<\/jats:p>","DOI":"10.52586\/4937","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T01:25:30Z","timestamp":1627003530000},"source":"Crossref","is-referenced-by-count":6,"title":["Nodal tumor volume as a prognostic factor for head and neck squamous cell carcinoma: a systematic review"],"prefix":"10.31083","volume":"26","author":[{"given":"Paris T.","family":"Moumoulidis","sequence":"first","affiliation":[{"name":"1st Department of Otolaryngology - Head & Neck Surgery, Medical School, National & Kapodistrian University of Athens (NKUA), Hippokrateio Hospital, 11527 Athens, Greece"},{"name":"ENT Department, ELPIS General Hospital, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasia","family":"Pavlopoulou","sequence":"first","affiliation":[{"name":"Izmir Biomedicine and Genome Center (IBG), 35340 Balcova, Izmir, Turkey"},{"name":"Izmir International Biomedicine and Genome Institute, Dokuz Eyl\u00fcl University, 35340 Balcova, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Re\u015fat","family":"\u00dcnal","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, 48000 K\u00f6tekli, Mu\u011fla, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifigeneia","family":"Mavragani","sequence":"first","affiliation":[{"name":"DNA Damage Laboratory, Department of Physics, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), 15780 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros G.","family":"Georgakilas","sequence":"first","affiliation":[{"name":"DNA Damage Laboratory, Department of Physics, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), 15780 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthymios","family":"Kyrodimos","sequence":"first","affiliation":[{"name":"1st Department of Otolaryngology - Head & Neck Surgery, Medical School, National & Kapodistrian University of Athens (NKUA), Hippokrateio Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Cerezo L, Millan I, Torre A, Aragon G, Otero J. 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Human papillomavirus and survival of patients with oropharyngeal cancer. New England Journal of Medicine. 2010; 363: 24\u201335.","DOI":"10.1056\/NEJMoa0912217"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Saada-Bouzid E, Peyrade F, Guigay J. Immunotherapy in recurrent and or metastatic squamous cell carcinoma of the head and neck. 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