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This is followed by a description of the basic principles of these treatments and a literature review on possible mechanisms describing the coupling of these treatments with biological responses. These response mechanisms include the cell membrane and its embedded receptors, channels and pumps, as well as signaling cascades within the cell and links to cell organelles. We also discuss the magnetic contribution to coupling EMF, as well as the recent finding of cryptochrome as a putative magnetosensor. Our conclusion summarizes the complex network of causal factors elicited by EMF such as those arising from the cell membrane via signaling cascades to radical oxygen species, nitric oxide, growth factors, cryptochromes and other mechanisms involving epigenetic and genetic changes.<\/jats:p>","DOI":"10.52586\/s561","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T07:57:55Z","timestamp":1638518275000},"source":"Crossref","is-referenced-by-count":16,"title":["A short review on the influence of magnetic fields on neurological diseases"],"prefix":"10.31083","volume":"13","author":[{"given":"Richard H. 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Modulation of cortical excitability induced by repetitive transcranial magnetic stimulation: influence of timing and geometrical parameters and underlying mechanisms. Progress in Neurobiology. 2011; 93: 59\u201398.","DOI":"10.1016\/j.pneurobio.2010.10.003"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Panagopoulos DJ, Margaritis LH. The identification of an intensity \u2019window\u2019 on the bioeffects of mobile telephony radiation. International Journal of Radiation Biology. 2010; 86: 358\u2013366.","DOI":"10.3109\/09553000903567979"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Marko S. Markov. \u201cBiological Windows\u201d: A Tribute to W. Ross Adey. The Environmentalist. 2005, 25: 67\u201374.","DOI":"10.1007\/s10669-005-4268-8"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Cho SI, Nam YS, Chu LY, Lee JH, Bang JS, Kim HR, et al. Extremely low-frequency magnetic fields modulate nitric oxide signaling in rat brain. Bioelectromagnetics. 2012; 33: 568\u2013574.","DOI":"10.1002\/bem.21715"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Parkin B, Ekhtiari H, Walsh V. Non-invasive Human Brain Stimulation in Cognitive Neuroscience: A Primer. Neuron. 2015; 87: 932\u2013945.","DOI":"10.1016\/j.neuron.2015.07.032"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Dayan E, Censor N, Buch ER, Sandrini M, Cohen LG. Noninvasive brain stimulation: from physiology to network dynamics and back. Nature Neuroscience. 2013; 16: 838\u2013844.","DOI":"10.1038\/nn.3422"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Hallett M. Transcranial Magnetic Stimulation: A Primer. Neuron. 2007; 55: 187\u2013199.","DOI":"10.1016\/j.neuron.2007.06.026"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Ziemann U, Rothwell JC, Ridding MC. Interaction between intracortical inhibition and facilitation in human motor cortex. Journal of Physiology. 1996; 496: 873\u2013881.","DOI":"10.1113\/jphysiol.1996.sp021734"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Beitz JM. Parkinson\u2019s disease: a review. Frontiers in Bioscience. 2014; 6: 65\u201374.","DOI":"10.2741\/S415"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Vadal\u00e0 M, Vallelunga A, Palmieri L, Palmieri B, Morales-Medina JC, Iannitti T. Mechanisms and therapeutic applications of electromagnetic therapy in Parkinson\u2019s disease. Behavioral and Brain Functions. 2015; 11: 26.","DOI":"10.1186\/s12993-015-0070-z"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Morberg BM, Malling AS, Jensen BR, Gredal O, Bech P, Wermuth L. Parkinson\u2019s disease and transcranial pulsed electromagnetic fields: A randomized clinical trial. Movement Disorders. 2017; 32: 625\u2013626.","DOI":"10.1002\/mds.26927"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Sandyk R. Transcranial AC pulsed applications of weak electromagnetic fields reduces freezing and falling in progressive supranuclear palsy: a case report. International Journal of Neuroscience. 1998; 94: 41\u201354.","DOI":"10.3109\/00207459808986437"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Malling ASB, Morberg BM, Wermuth L, Gredal O, Bech P, Jensen BR. Effect of transcranial pulsed electromagnetic fields (T-PEMF) on functional rate of force development and movement speed in persons with Parkinson\u2019s disease: A randomized clinical trial. PLoS ONE. 2018; 13: e0204478.","DOI":"10.1371\/journal.pone.0204478"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Malling ASB, Morberg BM, Wermuth L, Gredal O, Bech P, Jensen BR. The effect of 8\u2009weeks of treatment with transcranial pulsed electromagnetic fields on hand tremor and inter-hand coherence in persons with Parkinson\u2019s disease. Journal of NeuroEngineering and Rehabilitation. 2019; 16: 19.","DOI":"10.1186\/s12984-019-0491-2"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Sandyk R. Transcranial AC pulsed applications of weak electromagnetic fields reduces freezing and falling in progressive supranuclear palsy: a case report. International Journal of Neuroscience. 1998; 94: 41\u201354.","DOI":"10.3109\/00207459808986437"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Khedr EM, Farweez HM, Islam H. Therapeutic effect of repetitive transcranial magnetic stimulation on motor function in Parkinson\u2019s disease patients. European Journal of Neurology. 2003; 10: 567\u2013572.","DOI":"10.1046\/j.1468-1331.2003.00649.x"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Shimamoto H, Takasaki K, Shigemori M, Imaizumi T, Ayabe M, Shoji H. Therapeutic effect and mechanism of repetitive transcranial magnetic stimulation in Parkinson\u2019s disease. Journal of Neurology. 2001; 3: III48\u2013III52.","DOI":"10.1007\/PL00007826"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Sandyk R. Treatment with AC pulsed electromagnetic fields improves olfactory function in Parkinson\u2019s disease. International Journal of Neuroscience. 1999; 97: 225\u2013233.","DOI":"10.3109\/00207459909000662"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Puspita L, Chung SY, Shim J. Oxidative stress and cellular pathologies in Parkinson\u2019s disease. Molecular Brain. 2017; 10: 53.","DOI":"10.1186\/s13041-017-0340-9"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"N. Kolodkin A, Sharma RP, Colangelo AM, Ignatenko A, Martorana F, Jennen D, et al. 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BioMed Research International. 2019; 2019: 1431760.","DOI":"10.1155\/2019\/1431760"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Ye H, Steiger A. Neuron matters: electric activation of neuronal tissue is dependent on the interaction between the neuron and the electric field. Journal of Neuroengineering and Rehabilitation. 2015; 12: 65.","DOI":"10.1186\/s12984-015-0061-1"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Pennisi G, Ferri R, Lanza G, Cantone M, Pennisi M, Puglisi V, et al. Transcranial magnetic stimulation in Alzheimer\u2019s disease: a neurophysiological marker of cortical hyperexcitability. Journal of Neural Transmission. 2011; 118: 587\u2013598.","DOI":"10.1007\/s00702-010-0554-9"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Simmonds MJ, Detterich JA, Connes P. Nitric oxide, vasodilation and the red blood cell. Biorheology. 2014; 51: 121\u2013134.","DOI":"10.3233\/BIR-140653"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Capelli E, Torrisi F, Venturini L, Granato M, Fassina L, Lupo GFD, et al. Low-Frequency Pulsed Electromagnetic Field is Able to Modulate miRNAs in an Experimental Cell Model of Alzheimer\u2019s Disease. Journal of Healthcare Engineering. 2017; 2017: 2530270.","DOI":"10.1155\/2017\/2530270"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Guerriero F, Ricevuti G. Extremely low frequency electromagnetic fields stimulation modulates autoimmunity and immune responses: a possible immuno-modulatory therapeutic effect in neurodegenerative diseases. Neural Regeneration Research. 2016; 11: 1888\u20131895.","DOI":"10.4103\/1673-5374.195277"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Dobson R, Giovannoni G. Multiple sclerosis\u2014a review. European Journal of Neurology. 2019; 26: 27\u201340.","DOI":"10.1111\/ene.13819"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Sakamoto N, Ohashi T, Sato M. Effect of magnetic field on nitric oxide synthesis of cultured endothelial cells. International Journal of Applied Electromagnetics and Mechanics. 2001; 14: 317\u2013322.","DOI":"10.3233\/JAE-2002-403"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"abdel Naseer M, Rabah AM, Rashed LA, Hassan A, Fouad AM. Glutamate and Nitric Oxide as biomarkers for disease activity in patients with multiple sclerosis. Multiple Sclerosis and Related Disorders. 2020; 38: 101873.","DOI":"10.1016\/j.msard.2019.101873"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Di Sante G, Amadio S, Sampaolese B, Clementi ME, Valentini M, Volont\u00e9 C, et al. The S100B Inhibitor Pentamidine Ameliorates Clinical Score and Neuropathology of Relapsing-Remitting Multiple Sclerosis Mouse Model. Cells. 2020; 9: 748.","DOI":"10.3390\/cells9030748"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Funk RHW, Knels L, Augstein A, Marquetant R, Dertinger HF. Potent stimulation of blood flow in fingers of volunteers after local short-term treatment with low-frequency magnetic fields from a novel device. Evidence-Based Complementary and Alternative Medicine. 2014; 2014: 543564.","DOI":"10.1155\/2014\/543564"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Cury Y, Picolo G, Gutierrez VP, Ferreira SH. Pain and analgesia: the dual effect of nitric oxide in the nociceptive system. Nitric Oxide - Biology and Chemistry. 2011; 25: 243\u2013254.","DOI":"10.1016\/j.niox.2011.06.004"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Hochsprung A, Escudero-Uribe S, Ib\u00e1\u00f1ez-Vera AJ, Izquierdo-Ayuso G. Effectiveness of monopolar dielectric transmission of pulsed electromagnetic fields for multiple sclerosis-related pain: a pilot study. Neurolog\u00eda. 2021; 36: 433\u2013439.","DOI":"10.1016\/j.nrleng.2018.03.003"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Carson JJ, Prato FS, Drost DJ, Diesbourg LD, Dixon SJ. Time-varying magnetic fields increase cytosolic free Ca2+ in HL-60 cells. American Journal of Physiology-Cell Physiology. 1990; 259: C687\u2013C692.","DOI":"10.1152\/ajpcell.1990.259.4.C687"},{"key":"ref38","unstructured":"Funk RH. Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell. American Journal of Translational Research. 2018; 10: 1260\u20131272."},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Markov MS. Magnetic field therapy: a review. Electromagnetic Biology and Medicine. 2007; 26: 1\u201323.","DOI":"10.1080\/15368370600925342"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Funk RHW, Monsees TK. Effects of Electromagnetic Fields on Cells: Physiological and Therapeutical Approaches and Molecular Mechanisms of Interaction. Cells Tissues Organs. 2006; 182: 59\u201378.","DOI":"10.1159\/000093061"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Funk RHW, Monsees T, \u00d6zkucur N. Electromagnetic effects - from cell biology to medicine. Progress in Histochemistry and Cytochemistry. 2009; 43: 177\u2013264.","DOI":"10.1016\/j.proghi.2008.07.001"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Levin M. Large-scale biophysics: ion flows and regeneration. Trends in Cell Biology. 2007; 17: 261\u2013270.","DOI":"10.1016\/j.tcb.2007.04.007"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Sundelacruz S, Levin M, Kaplan DL. Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells. PLoS ONE. 2008; 3: e3737.","DOI":"10.1371\/journal.pone.0003737"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Levin M, Selberg J, Rolandi M. Endogenous Bioelectrics in Development, Cancer, and Regeneration: Drugs and Bioelectronic Devices as Electroceuticals for Regenerative Medicine. IScience. 2019; 22: 519\u2013533.","DOI":"10.1016\/j.isci.2019.11.023"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Siebner HR, Hartwigsen G, Kassuba T, Rothwell JC. How does transcranial magnetic stimulation modify neuronal activity in the brain? Implications for studies of cognition. Cortex. 2009; 45: 1035\u20131042.","DOI":"10.1016\/j.cortex.2009.02.007"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Peng L, Fu C, Wang L, Zhang Q, Liang Z, He C, et al. The Effect of Pulsed Electromagnetic Fields on Angiogenesis. Bioelectromagnetics. 2021; 42: 250\u2013258.","DOI":"10.1002\/bem.22330"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Pall ML. Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects. Journal of Cellular and Molecular Medicine. 2013; 17: 958\u2013965.","DOI":"10.1111\/jcmm.12088"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Frey AH. Electromagnetic field interactions with biological systems. FASEB Journal. 1993; 7: 272\u2013281.","DOI":"10.1096\/fasebj.7.2.8440406"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Babus LW, Little EM, Keenoy KE, Minami SS, Chen E, Song JM, et al. Decreased dendritic spine density and abnormal spine morphology in Fyn knockout mice. Brain Research. 2011; 1415: 96\u2013102.","DOI":"10.1016\/j.brainres.2011.07.059"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Xie Q, Yang Y, Pan W. Combined effect of repetitive transcranial magnetic stimulation and physical exercise on cortical plasticity. Neural Regeneration Research. 2020; 15: 1986\u20131994.","DOI":"10.4103\/1673-5374.282239"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Murphy SC, Palmer LM, Nyffeler T, M\u00fcri RM, Larkum ME. Transcranial magnetic stimulation (TMS) inhibits cortical dendrites. Elife. 2016; 5: e13598.","DOI":"10.7554\/eLife.13598"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Kindzelskii AL, Petty HR. Ion channel clustering enhances weak electric field detection by neutrophils: apparent roles of SKF96365-sensitive cation channels and myeloperoxidase trafficking in cellular responses. European Biophysics Journal. 2005; 35: 1\u201326.","DOI":"10.1007\/s00249-005-0001-2"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Ozkucur N, Perike S, Sharma P, Funk RHW. Persistent directional cell migration requires ion transport proteins as direction sensors and membrane potential differences in order to maintain directedness. BMC Cell Biology. 2011; 12: 4.","DOI":"10.1186\/1471-2121-12-4"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Cho MR, Thatte HS, Lee RC, Golan DE. Integrin-dependent human macrophage migration induced by oscillatory electrical stimulation. Annals of Biomedical Engineering. 2000; 28: 234\u2013243.","DOI":"10.1114\/1.263"},{"key":"ref55","unstructured":"Ren Q, Zhou J, Wang MG, Chen KM. Pulsed electromagnetic fields stimulating osteogenic differentiation and maturation involves primary cilia-PI3K\/AKT pathway. Beijing Da Xue Xue Bao Yi Xue Ban. 2019; 51: 245\u2013251. (In Chinese)"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Zhang L, Zhou L, Vega-Gonz\u00e1lez A, Mendoza D, Drucker-Col\u00edn R. Extremely low frequency magnetic fields promote neurite varicosity formation and cell excitability in cultured rat chromaffin cells. Comparative Biochemistry and Physiology, Part C. 1997; 118: 295\u2013299.","DOI":"10.1016\/S0742-8413(97)00165-5"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Rovini A, Heslop K, Hunt EG, Morris ME, Fang D, Gooz M, et al. Quantitative analysis of mitochondrial membrane potential heterogeneity in unsynchronized and synchronized cancer cells. FASEB Journal. 2021; 35: e21148.","DOI":"10.1096\/fj.202001693R"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Tyner KM, Kopelman R, Philbert MA. \u201cNanosized Voltmeter\u201d Enables Cellular-Wide Electric Field Mapping. Biophysical Journal. 2007; 93: 1163\u20131174.","DOI":"10.1529\/biophysj.106.092452"},{"key":"ref59","doi-asserted-by":"crossref","unstructured":"Lee YK, Kopelman R. Nanoparticle PEBBLE sensors in live cells. Methods in Enzymology. 2012; 504: 419\u2013470.","DOI":"10.1016\/B978-0-12-391857-4.00021-5"},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"Funk RHW. Endogenous electric fields as guiding cue for cell migration. Frontiers in Physiology. 2015; 6: 143.","DOI":"10.3389\/fphys.2015.00143"},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"T\u00fanez I, S\u00e1nchez-L\u00f3pez F, Ag\u00fcera E, Fern\u00e1ndez-Bola\u00f1os R, S\u00e1nchez FM, Tasset-Cuevas I. Important role of oxidative stress biomarkers in Huntington\u2019s disease. Journal of Medicinal Chemistry. 2011; 54: 5602\u20135606.","DOI":"10.1021\/jm200605a"},{"key":"ref62","doi-asserted-by":"crossref","unstructured":"Medina-Fern\u00e1ndez FJ, Escribano BM, Padilla-Del-Campo C, Drucker-Col\u00edn R, Pascual-Leone \u00c1, T\u00fanez I. Transcranial magnetic stimulation as an antioxidant. Free Radical Research. 2018; 52: 381\u2013389.","DOI":"10.1080\/10715762.2018.1434313"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"Cicho\u0144 N, Czarny P, Bijak M, Miller E, \u015aliwi\u0144ski T, Szemraj J, et al. Benign Effect of Extremely Low-Frequency Electromagnetic Field on Brain Plasticity Assessed by Nitric Oxide Metabolism during Poststroke Rehabilitation. Oxidative Medicine and Cellular Longevity. 2017; 2017: 2181942.","DOI":"10.1155\/2017\/2181942"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Karabakhtsian R, Broude N, Shalts N, Kochlatyi S, Goodman R, Henderson AS. Calcium is necessary in the cell response to EM fields. FEBS Letters. 1994; 349: 1\u20136.","DOI":"10.1016\/0014-5793(94)00618-0"},{"key":"ref65","doi-asserted-by":"crossref","unstructured":"Yao F, Li Z, Cheng L, Zhang L, Zha X, Jing J. Low frequency pulsed electromagnetic field promotes differentiation of oligodendrocyte precursor cells through upregulation of miR-219-5p in vitro. Life Sciences. 2019; 223: 185\u2013193.","DOI":"10.1016\/j.lfs.2019.03.031"},{"key":"ref66","doi-asserted-by":"crossref","unstructured":"Eti\u00e9vant A, Manta S, Latapy C, Magno LAV, Fecteau S, Beaulieu J. Repetitive transcranial magnetic stimulation induces long-lasting changes in protein expression and histone acetylation. Scientific Reports. 2015; 5: 16873.","DOI":"10.1038\/srep16873"},{"key":"ref67","doi-asserted-by":"crossref","unstructured":"Consales C, Merla C, Marino C, Benassi B. The epigenetic component of the brain response to electromagnetic stimulation in Parkinson\u2019s Disease patients: A literature overview. Bioelectromagnetics. 2018; 39: 3\u201314.","DOI":"10.1002\/bem.22083"},{"key":"ref68","doi-asserted-by":"crossref","unstructured":"Jiang D, Li J, Zhang J, Xu S, Kuang F, Lang H, et al. Electromagnetic pulse exposure induces overexpression of beta amyloid protein in rats. Archives of Medical Research. 2013; 44: 178\u2013184.","DOI":"10.1016\/j.arcmed.2013.03.005"},{"key":"ref69","doi-asserted-by":"crossref","unstructured":"Kim JH, Yu D, Huh YH, Lee EH, Kim H, Kim HR. Long-term exposure to 835\u2009MHz RF-EMF induces hyperactivity, autophagy and demyelination in the cortical neurons of mice. Scientific Reports. 2017; 7: 41129.","DOI":"10.1038\/srep41129"},{"key":"ref70","doi-asserted-by":"crossref","unstructured":"Marchesi N, Osera C, Fassina L, Amadio M, Angeletti F, Morini M, et al. Autophagy is modulated in human neuroblastoma cells through direct exposition to low frequency electromagnetic fields. Journal of Cellular Physiology. 2014; 229: 1776\u20131786.","DOI":"10.1002\/jcp.24631"},{"key":"ref71","doi-asserted-by":"crossref","unstructured":"Thomson AC, Kenis G, Tielens S, de Graaf TA, Schuhmann T, Rutten BPF, et al. Transcranial Magnetic Stimulation-Induced Plasticity Mechanisms: TMS-Related Gene Expression and Morphology Changes in a Human Neuron-Like Cell Model. Frontiers in Molecular Neuroscience. 2020; 13: 528396.","DOI":"10.3389\/fnmol.2020.528396"},{"key":"ref72","doi-asserted-by":"crossref","unstructured":"Sherrard RM, Morellini N, Jourdan N, El-Esawi M, Arthaut L, Niessner C, et al. Low-intensity electromagnetic fields induce human cryptochrome to modulate intracellular reactive oxygen species. PLoS Biology. 2018; 16: e2006229.","DOI":"10.1371\/journal.pbio.2006229"},{"key":"ref73","doi-asserted-by":"crossref","unstructured":"Pooam M, Jourdan N, El Esawi M, Sherrard RM, Ahmad M. HEK293 cell response to static magnetic fields via the radical pair mechanism may explain therapeutic effects of pulsed electromagnetic fields. PLoS ONE. 2020; 15: e0243038.","DOI":"10.1371\/journal.pone.0243038"},{"key":"ref74","doi-asserted-by":"crossref","unstructured":"Schieber M, Chandel NS. ROS function in redox signaling and oxidative stress. Current Biology. 2014; 24: R453\u2013R462.","DOI":"10.1016\/j.cub.2014.03.034"},{"key":"ref75","doi-asserted-by":"crossref","unstructured":"Lin C, Todo T. The cryptochromes. Genome Biology. 2005; 6: 220.","DOI":"10.1186\/gb-2005-6-5-220"},{"key":"ref76","doi-asserted-by":"crossref","unstructured":"Arthaut L, Jourdan N, Mteyrek A, Procopio M, El-Esawi M, d\u2019Harlingue A, et al. Blue-light induced accumulation of reactive oxygen species is a consequence of the Drosophila cryptochrome photocycle. PLoS ONE. 2017; 12: e0171836.","DOI":"10.1371\/journal.pone.0171836"},{"key":"ref77","doi-asserted-by":"crossref","unstructured":"Marley R, Giachello CNG, Scrutton NS, Baines RA, Jones AR. Cryptochrome-dependent magnetic field effect on seizure response in Drosophila larvae. Scientific Reports. 2014; 4: 5799.","DOI":"10.1038\/srep05799"},{"key":"ref78","doi-asserted-by":"crossref","unstructured":"Dufor T, Grehl S, Tang AD, Doulazmi M, Traor\u00e9 M, Debray N, et al. Neural circuit repair by low-intensity magnetic stimulation requires cellular magnetoreceptors and specific stimulation patterns. Science Advances. 2019; 5: eaav9847.","DOI":"10.1126\/sciadv.aav9847"},{"key":"ref79","doi-asserted-by":"crossref","unstructured":"Ehnert S, Fentz A, Schreiner A, Birk J, Wilbrand B, Ziegler P, et al. Extremely low frequency pulsed electromagnetic fields cause antioxidative defense mechanisms in human osteoblasts via induction of *O2(-) and H2O2. Scientific Reports. 2017; 7: 14544.","DOI":"10.1038\/s41598-017-14983-9"},{"key":"ref80","doi-asserted-by":"crossref","unstructured":"Nam S, Kim S, Yoon K, Hong HS, Son Y. Preconditioning with repetitive electromagnetic stimulation enhances activity of bone marrow mesenchymal stem cells from elderly patients through Erk1\/2 via nitric oxide. International Journal of Molecular Medicine. 2020; 45: 678\u2013686.","DOI":"10.3892\/ijmm.2019.4450"},{"key":"ref81","doi-asserted-by":"crossref","unstructured":"Sundelacruz S, Levin M, Kaplan DL. Role of Membrane Potential in the Regulation of Cell Proliferation and Differentiation. Stem Cell Reviews and Reports. 2009; 5: 231\u2013246.","DOI":"10.1007\/s12015-009-9080-2"},{"key":"ref82","doi-asserted-by":"crossref","unstructured":"Funk RHW. Endogenous Bioelectric Phenomena and Interfaces for Exogenous Effects in: Bioengineering and Biophysical Aspects of Electromagnetic Fields. 4th eds., Greenebaum B, Barnes F, CRC Press, Taylor & Francis Group, Boca Raton, FL 2019.","DOI":"10.1201\/9781315186580-4"},{"key":"ref83","doi-asserted-by":"crossref","unstructured":"Funk RHW. Biophysical mechanisms complementing \u201dclassical\u201d cell biology. Frontiers in Bioscience - Landmark. 2018; 23: 921\u2013939.","DOI":"10.2741\/4625"}],"container-title":["Frontiers in Bioscience-Scholar"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/FBS\/13\/2\/10.52586\/S561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T14:56:19Z","timestamp":1732719379000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/FBS\/13\/2\/10.52586\/S561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,3]]},"references-count":83,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"alternative-id":["s1945-0516(21)00562-1"],"URL":"https:\/\/doi.org\/10.52586\/s561","relation":{},"ISSN":["1945-0516","1945-0524"],"issn-type":[{"value":"1945-0516","type":"print"},{"value":"1945-0524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,3]]},"article-number":"181"}}