{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:36:26Z","timestamp":1789569386689,"version":"build-2803163510"},"reference-count":40,"publisher":"Universa BV","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Orthop Belg"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>Femoral cartilage thickness may be an important objective parameter in detecting the progression of knee osteoarthritis(KOA). In this study, we aimed to examine the possible effects of intra-articular Hyaluronic Acid(HA) and platelet-rich plasma(PRP) injections on femoral cartilage thickness and to investigate their possible superiority over each other in KOA. A total of 40 KOA patients were included in the study and randomized to the HA and PRP groups. Pain complaints, stiffness, and functional status were evaluated with the Visual Analog Scale(VAS) and Western Ontario and Mc Master Universities Osteoarthritis(WOMAC) indices. Ultrasonography was used for measuring the femoral cartilage thickness. At the 6th month measurements, significant improvements were observed in VAS-rest, VAS-movement, and WOMAC scores in both HA and PRP groups compared to the measurements performed before the treatment. No significant difference was observed between the effects of the two treatment methods. There were significant changes in the medial, lateral and mean cartilage thicknesses on the symptomatic knee side in the HA group. The most important finding of this prospective randomized study, in which we compared the effects of PRP and HA injections on KOA, was the increase in knee femoral cartilage thickness in the HA injection group. This effect started in the 1st month and continued until the 6th month. No similar effect was detected with PRP injection. In addition to this basic result, both treatment approaches had significant positive effects on pain, stiffness, and function and no superiority was observed over each other.<\/jats:p>","DOI":"10.52628\/88.4.10243","type":"journal-article","created":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T22:15:23Z","timestamp":1677968123000},"page":"811-819","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of the effect of intra-articular platelet-rich plasma and hyaluronic acid injections on femoral cartilage thickness in chronic knee osteoarthritis"],"prefix":"10.52628","volume":"88","author":[{"given":"Okan","family":"K\u00fc\u00e7\u00fckakka\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teoman","family":"Aydin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozan Volkan","family":"Yurdakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27062","published-online":{"date-parts":[[2023,2]]},"reference":[{"key":"ref0","unstructured":"Grazio S, Balen D. Obesity: risk factor and predictor of osteoarthritis. Lijec Vjesn. 2009;131(1-2):22-26."},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Lawrence RC, Felson DT, Helmick CG. et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II. Arthritis Rheum. 2008;58(1):26-35.","DOI":"10.1002\/art.23176"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377(9783):2115-2126.","DOI":"10.1016\/s0140-6736(11)60243-2"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Hussain S, Neilly D, Baliga S, Patil S, Meek R. Knee osteoarthritis: a review of management options. Scott Med J. 2016;61(1):7-16.","DOI":"10.1177\/0036933015619588"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Bruy\u00e8re O, Honvo G, Veronese N. et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019;49(3):337-350.","DOI":"10.1016\/j.semarthrit.2019.04.008"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Bannuru RR, Osani M, Vaysbrot E. et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 2019;27(11):1578-1589.","DOI":"10.1016\/j.joca.2019.06.011"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Maheu E, Bannuru RR, Herrero-Beaumont G, Allali F, Bard H, Migliore A. Why we should definitely include intra-articular hyaluronic acid as a therapeutic option in the management of knee osteoarthritis: results of an ex-tensive critical literature review. Semin Arthritis Rheum. 2019;48(4):563-572.","DOI":"10.1016\/j.semarthrit.2018.06.002"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Zhao J, Huang H, Liang G, Zeng LF, Yang W, Liu J. Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2020;21(1):224.","DOI":"10.1186\/s12891-020-03262-w"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Bennell KL, Hunter DJ, Paterson KL. Platelet-rich plasma for the management of hip and knee osteoarthritis. Curr Rheumatol Rep. 2017;19(5):24.","DOI":"10.1007\/s11926-017-0652-x"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Schmitz RJ, Wang H-M, Polprasert DR, Kraft RA, Pietrosimone BG. Evaluation of knee cartilage thickness: a comparison between ultrasound and magnetic resonance imaging methods. Knee. 2017;24(2):217-223.","DOI":"10.1016\/j.knee.2016.10.004"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Buck R, Wyman B, Le Graverand M-PH, Hudelmaier M, Wirth W, Eckstein F. Osteoarthritis may not be a one-way-road of cartilage loss\u2013comparison of spatial patterns of  cartilage change between osteoarthritic and healthy knees. Osteoarthritis Cartilage. 2010;18(3):329-335.","DOI":"10.1016\/j.joca.2009.11.009"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Abraham AM, Goff I, Pearce MS, Francis RM, Birrell F. Reliability and validity of ultrasound imaging of features of knee osteoarthritis in the community. BMC Musculo-skelet Disord. 2011;12:70.","DOI":"10.1186\/1471-2474-12-70"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Altman R, Asch E, Bloch D. et al. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Arthritis Rheum. 1986;29(8):1039-1049.","DOI":"10.1002\/art.1780290816"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Kellgren JH, Lawrence J. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957;16(4):494-502.","DOI":"10.1136\/ard.16.4.494"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Crichton N. Visual analogue scale (VAS). J Clin Nurs. 2001;10(5):697-706.","DOI":"10.1046\/j.1365-2702.2001.00525.x"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"T\u00fcz\u00fcn E, Eker L, Aytar A, Da\u015fkapan A, Bayramo\u011flu M. Acceptability, reliability, validity and responsiveness of the Turkish version of WOMAC osteoarthritis index. Osteo- arthritis Cartilage. 2005;13(1):28-33.","DOI":"10.1016\/j.joca.2004.10.010"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Karaka\u015f A, Dilek B, \u015eahin MA, Ellidokuz H, \u015eenocak \u00d6. The effectiveness of pulsed ultrasound treatment on pain, function, synovial sac thickness and femoral cartilage thickness in patients with knee osteoarthritis: a randomized, double-blind clinical, controlled study. Clin Rehabil. 2020;34(12):1474-1484.","DOI":"10.1177\/0269215520942953"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Jan M-H, Chai H-M, Wang C-L, Lin Y-F, Tsai L-Y. Effects of repetitive shortwave diathermy for reducing synovitis in patients with knee osteoarthritis: an ultrasono- graphic study. Phys Ther. 2006;86(2):236-244.","DOI":"10.1093\/ptj\/86.2.236"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Kazam JK, Nazarian LN, Miller TT, Sofka CM, Parker L, Adler RS. Sonographic evaluation of femoral trochlear cartilage in patients with knee pain. J Ultrasound Med. 2011;30(6):797-802.","DOI":"10.7863\/jum.2011.30.6.797"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"\u00c7etin G, Kyio NH, Turgut S, \u00d6zkan T. Optimisation of Centrifugal Speed for PRPBAG\u00ae: A Novel Multiple Bag System for Preparing Platelet-Rich Plasma. Bezmialem Sci. 2021;9(3):351-355.","DOI":"10.14235\/bas.galenos.2021.5842"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Maheu E, Rannou F, Reginster J-Y. Efficacy and safety of hyaluronic acid in the management of osteoarthritis: evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016;45(4 Suppl):S28-S33.","DOI":"10.1016\/j.semarthrit.2015.11.008"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Pelletier J-P, Raynauld J-P, Abram F, Dorais M, Delorme P, Martel-Pelletier J. Exploring determinants pre-dicting response to intra-articular hyaluronic acid treatment in symptomatic knee osteoarthritis: 9-year follow-up data from the Osteoarthritis Initiative. Arthritis Res Ther. 2018;20(1):40.","DOI":"10.1186\/s13075-018-1538-7"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Bannuru RR, Schmid CH, Kent DM, Vaysbrot EE, Wong JB, McAlindon TE. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med. 2015;162(1):46-54.","DOI":"10.7326\/m14-1231"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Bannuru R, Natov N, Dasi U, Schmid C, McAlindon T. Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis\u2013meta-analysis. Osteo- arthritis Cartilage. 2011;19(6):611-619.","DOI":"10.1016\/j.joca.2010.09.014"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Strand V, McIntyre LF, Beach WR, Miller LE, Block JE. Safety and efficacy of US-approved viscosupplements for knee osteoarthritis: a systematic review and meta- analysis of randomized, saline-controlled trials. J Pain Res. 2015;8:217-228.","DOI":"10.2147\/jpr.s83076"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Bannuru RR, Natov NS, Obadan IE, Price LL, Schmid CH, McAlindon TE. Therapeutic trajectory of hyaluronic acid versus corticosteroids in the treatment of knee osteo- arthritis: A systematic review and meta-analysis. Arthritis Rheum. 2009;61(12):1704-1711.","DOI":"10.1002\/art.24925"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Shen L, Yuan T, Chen S, Xie X, Zhang C. The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials. J Orthop Surg Res. 2017;12(1):16.","DOI":"10.1186\/s13018-017-0521-3"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Johal H, Khan M, Yung S-hP. et al. Impact of platelet-rich plasma use on pain in orthopaedic surgery: a systematic review and meta-analysis. Sports Health. 2019;11(4):355-366.","DOI":"10.1177\/1941738119834972"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Sdeek M, Sabry D, El-Sdeek H, Darweash A. Intra-articular injection of Platelet rich plasma versus Hyaluronic acid for moderate knee osteoarthritis. A prospective, double-blind randomized controlled trial on 189 patients with follow-up for three years. Acta Orthop. Belg. 2021;87(4):729-734.","DOI":"10.52628\/87.4.18"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Cole BJ, Karas V, Hussey K, Merkow DB, Pilz K, Fortier LA. Hyaluronic acid versus platelet-rich plasma: a prospective, double-blind randomized controlled trial comparing clinical outcomes and effects on intra-articular biology for the treatment of knee osteoarthritis. Am J Sports Med. 2017;45(2):339-346.","DOI":"10.1177\/0363546516665809"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Di Martino A, Di Matteo B, Papio T. et al. Platelet-rich plasma versus hyaluronic acid injections for the treat- ment of knee osteoarthritis: results at 5 years of a double-blind, randomized controlled trial. Am J Sports Med. 2019;47(2):347-354.","DOI":"10.1177\/0363546518814532"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Belk JW, Kraeutler MJ, Houck DA, Goodrich JA, Dragoo JL, McCarty EC. Platelet-rich plasma versus hyaluronic acid for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Am J Sports Med. 2021;49(1):249-260.","DOI":"10.1177\/0363546520909397"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Tang JZ, Nie MJ, Zhao JZ, Zhang GC, Zhang Q, Wang B. Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis. J Orthop Surg Res. 2020;15(1):403.","DOI":"10.1186\/s13018-020-01919-9"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Buend\u00eda-L\u00f3pez D, Medina-Quir\u00f3s M, Mar\u00edn M\u00c1F-V. Clinical and radiographic comparison of a single LP-PRP injection, a single hyaluronic acid injection and daily NSAID administration with a 52-week follow-up: a randomized controlled trial. J Orthop Traumatol. 2018;19(1):3.","DOI":"10.1186\/s10195-018-0501-3"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Elik H, Do\u011fu B, Y\u0131lmaz F, Bego\u011flu FA, Kuran B. The efficiency of platelet-rich plasma treatment in patients with knee osteoarthritis. Musculoskelet Rehabil. 2020;33(1):127-138.","DOI":"10.3233\/bmr-181374"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"\u015een E\u0130, Y\u0131ld\u0131r\u0131m MA, Ye\u015filyurt T, Kesikta\u015f FN, D\u0131ra\u00e7o\u011flu D. Effects of platelet-rich plasma on the clinical outcomes and cartilage thickness in patients with knee osteoarthritis. J Back Musculoskelet Rehabil. 2020;33(4):597-605.","DOI":"10.3233\/bmr-181209"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Baki NMA, Nawito ZO, Abdelsalam NM. et al. Does Intra-Articular Injection of Platelet-Rich Plasma Have an Effect on Cartilage Thickness in Patients with Primary Knee Osteoarthritis? Curr Rheumatol Rev. 2021;17(3):294-302.","DOI":"10.2174\/1573397117666210114151701"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Tuan S, Liou I, Su H, Tsai Y, Chenc G, Sun S. Functional improvement and thickening of quadriceps muscle and femoral intercondylar cartilage after a single intra-articular injection of a new bionic cross-linked hyaluronic acid Flexotron Cross in the treatment of knee joint osteoarthritis. Khirurgiia (Mosk). 2020;(9):59-68.","DOI":"10.17116\/hirurgia202009159"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Tuan S, Liou I, Su H, Tsai Y, Chen G, Sun S. Improvement of self-reported functional scores and thickening of quadriceps and femoral intercondylar cartilage under ultra-sonography after single intra-articular injection of a novel cross-linked hyaluronic acid in the treatment of knee osteo-arthritis. J Back Musculoskelet Rehabil. 2018;31(4):709-718.","DOI":"10.3233\/bmr-170950"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Henrotin Y, Bannuru R, Malaise M. et al. Hyaluronan derivative HYMOVIS\u00ae increases cartilage volume and type II collagen turnover in osteoarthritic knee: data from MOKHA study. 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