{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T04:26:44Z","timestamp":1775536004674,"version":"3.50.1"},"reference-count":32,"publisher":"Universa BV","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Orthop Belg"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>In our study, we evaluated whether mean platelet volume (MPV) and neutrophil lymphocyte ratio (NLR) are predictive values in the diagnosis of Adolescent Idiopathic Scoliosis in patients diagnosed with scoliosis in our clinic. Approximately 15000 patients who applied to our spine outpatient clinic with the suspicion of scoliosis between 2011 and 2018 were reviewed retrospectively. 292 patients were included in the study. The patients were divided into 3 groups. Group 1; control group group 2; group with the possibility of developing scoliosis under follow-upand group 3; the patient group diagnosed with scoliosis. Spinal curvature degrees of the patients were measured using the Cobb method. The MPV and NLR values of the patients were compared with the degree of curvature measured by the cobb method. NLR was 2.17 \u00b1 2.10 K\/ul in Group 1, 2.42 \u00b1 1.76 K\/ul in Group 2, and 2.72 \u00b1 3.91 K\/ul in Group 3. Although the NLR of the 3rd group was higher than the other 2 groups, it was not statistically significant. (p &gt; 0.05). MPV was 7.90 \u00b1 1.07 fL in Group 1, 7.95 \u00b11.39 fL in Group 2, 8.33 \u00b1 1.37 fL in Group 3.MPV was higher in Group 3 and was found to be statistically significant (p=0.024). After adjusting for the effects of gender and age variables on the groups, the difference in MPV between groups became more significant (p=0.017) . While there was no statistically significant difference between the groups in terms of NLR, it was observed that MPV was statistically significantly higher in patients with AIS.Could this relationship be a promising inflammatory marker for AIS? We think that this question should be answered by studies involving larger patient and control groups.<\/jats:p>","DOI":"10.52628\/89.3.10621","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:40:03Z","timestamp":1699364403000},"page":"393-398","source":"Crossref","is-referenced-by-count":1,"title":["Mean platelet volume and neutrophil\/lymphocyte ratio in adolescent idiopathic scoliosis: can they be predictive value in diagnosis?"],"prefix":"10.52628","volume":"89","author":[{"given":"M","family":"\u00c7ELIK","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"I\u015eIK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"ARIKAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"KURTBO\u011eAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"BOZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27062","published-online":{"date-parts":[[2023,11]]},"reference":[{"key":"ref0","unstructured":"Herring JA. Tachdjian\u2019s Pediatric Orthopaedics. 3rd Edition, New York:W.B.Saunders Company, 2002: 213-299"},{"key":"ref1","unstructured":"Freeman BL. Scoliosis and Kyphosis. Canale S.T. Campbell\u2019s OperativeOrthopaedics, 10th Edition. Mosby, Philadelphia 2003; Volume 2; 1751-1837"},{"key":"ref2","unstructured":"Ahn UM1 , Ahn NU, Nallamshetty L, Buchowski JM, Rose PS, Miller NH, Kostuik JP, Sponseller PD. The etiology of adolescent idiopathic scoliosis. Am J Orthop (Belle Mead NJ). 2002 Jul;31(7):387-95. PMID: 12180624"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Lowe TG1 , Burwell RG, Dangerfield PH. Platelet calmodulin levels in adolescent idiopathic scoliosis (AIS): can they predict curve progression and severity? Summary of an electronic focus group debate of the IBSE.Eur Spine J. 2004 May;13(3):257-65. PMCID: PMC3468134 ,DOI: 10.1007\/s00586-003-0655-3","DOI":"10.1007\/s00586-003-0655-3"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Suk SI1 , Kim IK, Lee CK, Koh YD, Yeom JS. A study on platelet function in idiopathic scoliosis.1991Oct;14(10):1079-83PMID: 1946044 ,DOI: 10.3928\/0147-7447-19911001-06","DOI":"10.3928\/0147-7447-19911001-06"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Briggs C, Harrison P, Machin SJ: Continuing developments with the automated platelet count. Int J Lab Haematol 2007;29:1-15. PMID: 17474881, DOI: 10.1111\/j.1751-553X.2007.00909.x","DOI":"10.1111\/j.1751-553x.2007.00909.x"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996;7:157-61.PMID: 8735807","DOI":"10.1097\/00001721-199603000-00011"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Mangalpally KK, Siqueiros-Garcia A, Vaduganathan M et al: Platelet activation patterns in platelet size sub-populations: differential responses to aspirin invitro. J Thromb Thrombolysis 2010;30:251-62 PMID: 20502945 , DOI: 10.1007\/s11239-010-0489-x","DOI":"10.1007\/s11239-010-0489-x"},{"key":"ref8","unstructured":"Thompson CB, Jakubowski JA, Quinn PG et al: Platelet size as a determinant of platelet function. J Lab Clin Med 1983;101:205-13.PMID: 6822760"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Balta S, Celik T, Mikhailidis DP, Ozturk C, Demirkol S, Aparci M, et al. The relation between atherosclerosis and the neutrophillymphocyte ratio. Clin Appl Thromb Hemost 2015 Feb 9. PMID: 25667237, DOI: 10.1177\/1076029615569568","DOI":"10.1177\/1076029615569568"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Templeton AJ, McNamara MG, Seruga B, Vera-Badillo FE, Aneja P, Ocana A, et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst 2014; 106: dju124. PMID: 24875653, DOI: 10.1093\/jnci\/dju124","DOI":"10.1093\/jnci\/dju124"},{"key":"ref11","unstructured":"Burwell RG1 , Dangerfield PH.Pathogenesis of progressive adolescent idiopathic scoliosis. Platelet activation and vascular biology in immature vertebrae: an alternative molecular hypothesis Acta Orthop Belg. 2006 Jun;72(3):247-60 PMID: 16889135"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Leboeuf D, Letellier K, Alos N, Edery P, Moldovan F. Do estrogens impact adolescent idiopathic scoliosis? Trends Endocrinol Metab . 2009 May;20(4):147-52. Epub 2009 Apr 6. PMID: 19349194 DOI: 10.1016\/j.tem.2008.12.004","DOI":"10.1016\/j.tem.2008.12.004"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Sarwark, J. and Aubin, C.E. (2007) Growth considerations of the immature spine. J. Bone Joint Surg. Am. 89 (Suppl 1), 8\u201313 PMID: 17272418 DOI: 10.2106\/JBJS.F.00314","DOI":"10.2106\/jbjs.f.00314"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Sanders, J.O. et al. (2007) Maturity assessment and curve progression in girls with idiopathic scoliosis. J. Bone Joint Surg. Am. 89, 64\u201373 PMID: 17200312 DOI: 10.2106\/JBJS.F.00067","DOI":"10.2106\/jbjs.f.00067"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"O\u2019Brien, Michael F. et al.: 2003 Spinal Deformities: The Comprehensive Text CHAPTER 65 Idiopathic Scoliosis: Prevalence and Natural History SECTION 15 Pediatric Spine DOI: 10.1055\/b-0034-45194","DOI":"10.1055\/b-0034-45194"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Bunnell WP. The natural history of idiopathic scoliosis. Clin Orthop Relat Res. 1988;229:20-25.","DOI":"10.1097\/00003086-198804000-00003"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Miller NH. Cause and natural history of adolescent idiopathic scoliosis. Orthop Clin North Am. 1999;30(3):343-352.","DOI":"10.1016\/S0030-5898(05)70091-2"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Ta\u015fo\u011flu \u00d6, \u015eahin A, Karata\u015f G, Koyuncu E, Ta\u015fo\u011flu \u0130, Tecimel O, \u00d6zgirgin N. Blood mean platelet volume and platelet lymphocyte ratio as new predictors of hip osteoarthritis severity. Medicine (Baltimore). 2017Feb;96(6):e6073, PMID: 28178164 , PMCID: PMC5313021, DOI: 10.1097\/md.0000000000006073","DOI":"10.1097\/md.0000000000006073"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"\u015eahin M\u0130, K\u00f6ko\u011flu K, G\u00fclmez E . Mean platelet volume, neutrophil- and platelet to lymphocyte ratios are elevated in vestibular neuritis.J Clin Neurosci. 2019 Jun 12. pii: S0967-5868(19)30823-9. PMID: 31202637 , DOI: 10.1016\/j.jocn.2019.05.062","DOI":"10.1016\/j.jocn.2019.05.062"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Gogoi P, Sinha P , Gupta B, Firmal P , Rajaram S .Neutrophil-to-lymphocyte ratio and platelet indices in pre-eclampsia. Int J Gynaecol Obstet. 2019 Jan;144(1):16- 20.Epub 2018 Nov 11. 85, PMID: 30362112, DOI: 10.1002\/ijgo.12701","DOI":"10.1002\/ijgo.12701"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Akt\u00fcrk S, B\u00fcy\u00fckavc\u0131 R . Evaluation of blood neutrophil-lymphocyte ratio and platelet distribution width as inflammatory markers in patients with fibromyalgia Clin Rheumatol. 2017 Aug;36(8):1885-1889. Epub 2017 May 2. PMID: 28466420 DOI: 10.1007\/s10067-017-3647-0","DOI":"10.1007\/s10067-017-3647-0"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Mercan R, Bitik B, Tufan A, et al. The Association Between Neutrophil\/Lymphocyte Ratio and Disease Activity in Rheumatoid Arthritis and Ankylosing Spondylitis. Journal of clinical laboratory analysis. 2016;30(5):597-601.","DOI":"10.1002\/jcla.21908"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Gokmen F, Akbal A, Resorlu H, et al. Neutrophil-Lymphocyte Ratio Connected to Treatment Options and Inflammation Markers of Ankylosing Spondylitis. Journal of clinical laboratory analysis. 2015;29(4):294-298.","DOI":"10.1002\/jcla.21768"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Esra EI, Ismihan S, Sadiye S, P\u0131nar E, Salih I, Mahmut Y. May Neutrophil- Lymphocyte and Platelet-Lymphocyte Ratios Indicate Disease Activity in Ankylosing Spondylitis? Arch Rheum. 2015;30(2):130-137.","DOI":"10.5606\/archrheumatol.2015.4837"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med. 2012;5:2, PMID: 22281066, PMCID: PMC3277482, DOI: 10.1186\/1755-7682-5-2","DOI":"10.1186\/1755-7682-5-2"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Szkandera J, Stotz M, Eisner F, Absenger G, Stojakovic T, Samonigg H,et al. External validation of the derived neutrophil to lymphocyte ratio as a prognostic marker on a large cohort of pancreatic cancer patients. PloS One. 2013;8(11):e78225. PMID: 24223776, PMCID: PMC3817201 , DOI: 10.1371\/journal.pone.0078225","DOI":"10.1371\/journal.pone.0078225"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Chung JH et al. The significance of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in vestibular neuritis. Laryngoscope 2015;125(7): E257\u201361.Epub 2015 Feb 13,PMID: 25677212, DOI: 10.1002\/lary.25204","DOI":"10.1002\/lary.25204"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Afari ME, Bhat T. Neutrophil to lymphocyte ratio (NLR) and cardiovascular diseases: an update. Expert Rev Cardiovasc Ther 2016;14(5):573\u20137, PMID: 26878164, DOI: 10.1586\/14779072.2016.1154788","DOI":"10.1586\/14779072.2016.1154788"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Templeton AJ et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst 2014;106 (6):dju124. PMID: 24875653, DOI: 10.1093\/jnci\/dju124","DOI":"10.1093\/jnci\/dju124"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Gary T et al. Platelet-to-lymphocyte ratio: a novel marker for critical limb ischemia in peripheral arterial occlusive disease patients. PLoS ONE 2013;8(7): e67688. Print 2013. PMID: 23844064, PMCID: PMC3699634,DOI: 10.1371\/journal.pone.0067688","DOI":"10.1371\/journal.pone.0067688"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Kontorinis G et al. Neutrophil to lymphocyte ratio as a predictive marker of vestibular schwannoma growth. Otol Neurotol 2016;37(5):580\u20135. 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