{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:35:26Z","timestamp":1774434926246,"version":"3.50.1"},"reference-count":33,"publisher":"Universa BV","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Orthop Belg"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>Reconstruction of the anterior cruciate ligament (ACL) using hamstring autograft presents a greater risk of surgical site infection than other transplants (0.5% to 1.5%). Various prophylactic methods have been evaluated, such as double antibiotic protection with intravenous Cefazolin and soaking of the transplant with vancomycin, which results in a near- zero infection rate. This soaking method has only been studied in vitro, confirming the absence of toxicity of vancomycin on tenocytes. The primary objective of our study was to assess the mechanical quality of vancomycin-soaked tendon transplants at 6 months post-operatively. The secondary objective was to assess the rate of new rupture at 1 year.\n\nThis is a retrospective, single-center study including patients who underwent ACL reconstruction using a vancomycin- soaked hamstring autograft at Rennes University Hospital between December 2018 and February 2021. An objective assessment of joint laxity by means of the GNRB\u00ae at 134N was performed at 6 months post-operatively and a clinical evaluation (Lysholm and subjective IKDC questionnaires) at 1 year were performed.\n\nFifty-three patients aged between 18 and 57 years were included. At 6 months, GNRB\u00ae of the operated knee joints was significantly different compared with the non-operated ones but was below the threshold for complete or partial rupture according to the manufacturer\u2019s clinical significance threshold (3 mm for a complete rupture and 1.5 mm for a partial rupture). At one year, 3.8% of our population had an early rupture, the reason for which was technical defects in the positioning of the graft.\n\nThe stability of knees reconstructed with a Vancomycine soaked ACL graft is comparable with that of the contralateral knee with an intact ACL.\n\nLevel of evidence : IV, retrospective study.<\/jats:p>","DOI":"10.52628\/90.3.12980","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T20:52:57Z","timestamp":1737665577000},"page":"415-420","source":"Crossref","is-referenced-by-count":2,"title":["Vancomycin soaking of ACL reconstructions does not alter the mechanical strength"],"prefix":"10.52628","volume":"90","author":[{"given":"V","family":"JAHIER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"MAXIMEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"GUILLEMONT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q","family":"BIDARD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"ROPARS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"COMMON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27062","published-online":{"date-parts":[[2025,1]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Maletis GB, Inacio MCS, Reynolds S, Desmond JL, Maletis MM, Funahashi TT. Incidence of Postoperative Anterior Cruciate Ligament Reconstruction Infections: Graft Choice Makes a Difference. Am J Sports Med. 2013;41:1780-5.","DOI":"10.1177\/0363546513490665"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Barker JU, Drakos MC, Maak TG, Warren RF, Williams RJ, Allen AA. Effect of Graft Selection on the Incidence of Postoperative Infection in Anterior Cruciate Ligament Reconstruction. Am J Sports Med. 2010;38:281-6.","DOI":"10.1177\/0363546509346414"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"P\u00e9rez-Prieto D, Portillo ME, Torres-Claramunt R, Pelfort X, Hinarejos P, Monllau JC. Contamination occurs during ACL graft harvesting and manipulation, but it can be easily eradicated. Knee Surg Sports Traumatol Arthrosc. 2018;26:558-62.","DOI":"10.1007\/s00167-017-4735-z"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Vertullo CJ, Quick M, Jones A, Grayson JE. A Surgical Technique Using Presoaked Vancomycin Hamstring Grafts to Decrease the Risk of Infection After Anterior Cruciate Ligament Reconstruction. Arthrosc J Arthrosc Relat Surg. 2012;28:337- 42.","DOI":"10.1016\/j.arthro.2011.08.301"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Naendrup JH, Marche B, de SA D, Koenen P, Otchwemah R, Wafaisade A, et al. Vancomycin-soaking of the graft reduces the incidence of septic arthritis following ACL reconstruction: results of a systematic review and meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2020;28:1005-13.","DOI":"10.1007\/s00167-019-05353-1"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Schuster P, Schlumberger M, Mayer P, Eichinger M, Ge\u00dflein M, Reddemann F, et al. Soaking of the graft in vancomycin dramatically reduces the incidence of postoperative septic arthritis after anterior cruciate ligament reconstruction. 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