{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:18:09Z","timestamp":1783937889216,"version":"3.55.0"},"reference-count":0,"publisher":"Universa BV","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,29]]},"abstract":"<jats:p>Objective: The aim of this study was to evaluate the effectiveness of Intra-articular abdominal adipose-derived mesenchymal stem cell (AD-MSC) therapy in patients diagnosed with knee osteoarthritis and to compare its effectiveness in patients with grade 2 and grade 3 osteoarthritis.\n\nMaterial and Method: The study group comprised 48 patients over the age of 18 that were diagnosed with Grade II or Grade III (Kellgren-Lawrence) primary knee osteoarthritis. Two-way comparative knee radiography was performed for all patients before the procedure. Intra-articular abdominal adipose-derived mesenchymal stem cell (AD-MSC) therapy was applied to all patients. The patients were evaluated with the VAS and WOMAC index before the treatment and 3 months and 6 months after the treatment.\n\nResults: A statistically significant decrease was found in the six-month follow-up WOMAC and VAS scores compared to the pre-treatment scores regardless of the grade of their osteoarthritis (p &lt;0.001).\n\nConclusion: In conclusion, it was observed that the intra-articular injection of the AD-MSCs provided satisfactory functional recovery and pain relief for patients with knee osteoarthritis at six-month follow-up. No procedure-related adverse events were observed during the follow-up period.<\/jats:p>","DOI":"10.52628\/91.3.10897","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T11:15:16Z","timestamp":1772190916000},"page":"257","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of the Outcomes of the Intra-articular Abdominal Adipose- Derived Mesenchymal Stem Cell Therapy in Knee Osteoarthritis Patients"],"prefix":"10.52628","volume":"91","author":[{"given":"F","family":"EGE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"AKBA\u015e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"ISIK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27062","published-online":{"date-parts":[[2026,2,24]]},"container-title":["Acta Orthopaedica Belgica"],"original-title":[],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T11:15:16Z","timestamp":1772190916000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.actaorthopaedica.be\/archive\/volume-91\/autumn\/hip-and-knee\/assessment-of-the-outcomes-of-the-intra-articular-abdominal-adipose--derived-mesenchymal-stem-cell-t\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2,24]]},"published-print":{"date-parts":[[2025,9,29]]}},"URL":"https:\/\/doi.org\/10.52628\/91.3.10897","relation":{},"ISSN":["0001-6462"],"issn-type":[{"value":"0001-6462","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,29]]}}}