{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T06:47:27Z","timestamp":1793861247286,"version":"4.6.1"},"reference-count":0,"publisher":"Scandinavian Journal of Work, Environment and Health","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scand J Work Environ Health"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>OBJECTIVE: There is epidemiological evidence of an association between occupational pesticide exposure and cognitive impairment, but studies on the link with Alzheimer`s disease are scarce. We explored the association between agricultural exposures and Alzheimer`s disease in the AGRICAN cohort.<\/jats:p>\n                  <jats:p>METHODS: We analyzed the relationship between doctor-diagnosed Alzheimer`s disease and life-long exposures separately among men and women with the following exposures: work on a farm, pesticide use in any job, growing specific crops (N=13) or rearing animals (N=5), pesticide use on these crops\/livestock, with adjustment for age, education, smoking, alcohol consumption and body mass index.<\/jats:p>\n                  <jats:p>RESULTS: Among 109 287 participants in the analysis, 818 (267 men, 551 women) were classified as Alzheimer`s disease cases. Increased risks were seen for work on a farm [men: odds ratio (OR) 1.81, 95% confidence interval (CI) 0.92\u20133.57; women: OR 1.58, 95% CI 0.94\u20132.86] or pesticide use in any job (men: OR 1.14, 95% CI 0.85\u20131.53; women: OR 1.42, 95% CI 1.10\u20131.85). Risks for crops and livestock were close to unity when compared with non\u2013farmers, except for pigs (OR 1.38, 95% CI 1.01\u20131.89) and rapeseed among men (OR 1.45, 95% CI 1.00\u20132.11) and sunflower among women (OR 1.55, 95% CI 0.90\u20132.66). Using pesticides increased the risk among men especially for sheep\/goats (OR 1.98, 95% CI 1.18\u20133.34), pigs (OR 1.80, 95% CI 1.19\u20132.74), potatoes (OR 1.47, 95% CI 1.03\u20132.10) and meadows (OR 1.54, 95% CI 1.14\u20132.08). Among women, risks associated with pesticide use on crops were generally elevated, reaching a two\u2013fold increase for corn, rapeseed, sunflower, field peas and fruit growing.<\/jats:p>\n                  <jats:p>CONCLUSION: Our results suggest that agricultural exposures may play a role in Alzheimer\u2019s disease among both men and women, with the highest risks associated with pesticide use in certain livestock and crop activities.<\/jats:p>","DOI":"10.5271\/sjweh.4284","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:22:10Z","timestamp":1773771730000},"page":"310-321","source":"Crossref","is-referenced-by-count":1,"title":["Farming exposures and Alzheimer's disease: cross-sectional analysis within the French AGRICAN cohort"],"prefix":"10.5271","volume":"52","author":[{"given":"Victoire","family":"Madeline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9line","family":"Galvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"De Graaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Engelhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Lebailly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Baldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3229","published-online":{"date-parts":[[2026,3,17]]},"container-title":["Scandinavian Journal of Work, Environment &amp; Health"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:13:28Z","timestamp":1777544008000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sjweh.fi\/article\/4284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["4284"],"URL":"https:\/\/doi.org\/10.5271\/sjweh.4284","relation":{},"ISSN":["0355-3140","1795-990X"],"issn-type":[{"value":"0355-3140","type":"print"},{"value":"1795-990X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]}}}