{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:12:50Z","timestamp":1780618370016,"version":"3.54.1"},"reference-count":0,"publisher":"Kidney Cancer Association (KCA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["KCJ"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p>C-reactive protein may be overexpressed in kidney cancer tissue. We determined if urine C-reactive protein \nconcentration is greater in patients with high grade renal cell carcinoma or greater than healthy controls, and \ncompared to other urologic cancers and non-cancerous urologic disease. This observational study obtained prenephrectomy urine and plasma from 87 patients with a small imaged renal mass (\u22644cm) undergoing partial \nnephrectomy. Postoperative pathology established clear cell or papillary renal cell cancer, angiomyolipoma, \nchromophobe, or oncocytoma, and tumor Fuhrman grade. Follow-up urine was collected from 52 clear cell\/papillary \ncancer patients. Urine and\/or plasma were from bladder or prostate cancer patients and matched healthy controls. \nC-reactive protein was measured by enzyme-linked immunosorbent assay. Urine C-reactive protein in grade 1-2 \n(n=41) and grade 3-4 (n=24) renal cancer was 17- and 80-fold greater than controls, respectively. This decreased \n85% post-nephrectomy, suggesting origin from tumors and not systemic filtration from blood. Urine C-reactive \nprotein in angiomyolipoma, chromophobe, or oncocytoma, bladder or prostate cancer was less than grade 3-4 renal \ncancer. C-statistic to differentiate grade 1-2 from 3-4 clear cell\/papillary renal cancer was 0.98 (95% CI 0.95-1.00); \nsensitivity 1.00 (95% CI, 0.87-1.00), specificity 0.95 (95% CI 0.84-0.99). Two patients with remarkably high prenephrectomy urine C-reactive protein, but no others, developed late metastases. Pre-nephrectomy urine C-reactive \nprotein was increased in patients with high grade clear cell and papillary renal cancer, but not other renal or urologic c disease. Urine C-reactive protein may be used pre-surgically to noninvasively grade small renal masses, and may predict future renal cell cancer metastasis.<\/jats:p>","DOI":"10.52733\/kcj23n3-or1","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T04:42:16Z","timestamp":1760157736000},"page":"88-97","source":"Crossref","is-referenced-by-count":1,"title":["Urine C-reactive protein content and non-invasive  molecular grading of renal cell carcinoma"],"prefix":"10.52733","volume":"23","author":[{"given":"Jeremiah","family":"Morrissey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilee","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Kharasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"30466","published-online":{"date-parts":[[2025,10,15]]},"container-title":["Kidney Cancer Journal"],"original-title":[],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T04:42:16Z","timestamp":1760157736000},"score":1,"resource":{"primary":{"URL":"https:\/\/kidney-cancer-journal.com\/KCJ23n3-or1.php"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,10]]},"published-print":{"date-parts":[[2025,10]]}},"URL":"https:\/\/doi.org\/10.52733\/kcj23n3-or1","relation":{},"ISSN":["1933-0863","1933-0871"],"issn-type":[{"value":"1933-0863","type":"print"},{"value":"1933-0871","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]}}}