{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T14:12:03Z","timestamp":1784988723934,"version":"3.55.0"},"reference-count":0,"publisher":"Sociedad Argentina de Gastroenterologia","issue":"3","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACTA"],"abstract":"<jats:p>La ictericia neonatal requiere el diagn\u00f3stico diferencial entre la hiperbilirrubinemia no conjugada o indirecta y la hiperbilirrubinemia directa o conjugada, caracter\u00edstica de la colestasis neonatal, que siempre es patol\u00f3gica. Se recomienda en todo reci\u00e9n nacido de 15 d\u00edas o m\u00e1s de vida con ictericia realizar bilirrubina diferencial para poder detectarla. La colestasis se define por bilirrubina directa &gt; 1 mg\/dl (17 \u00b5mol\/L) y su frecuencia estimada durante el per\u00edodo neonatal es de 1:2.500 reci\u00e9n nacidos vivos. Las etiolog\u00edas m\u00e1s frecuentes son: infecciosas, gen\u00e9ticas\/metab\u00f3licas, obstructivas, endocrinol\u00f3gicas, t\u00f3xicas, inmunol\u00f3gicas. La causa m\u00e1s com\u00fan es la atresia biliar, que se manifiesta cl\u00ednicamente por ictericia y acolia, por lo que frente a estos signos siempre debe plantearse este diagn\u00f3stico como primera opci\u00f3n a descartar.Es fundamental que el diagn\u00f3stico de colestasis neonatal sea precoz para optimizar el manejo en las causas tratables y mejorar su pron\u00f3stico. Desafortunadamente, no siempre el diagn\u00f3stico es precoz. Es por esto que el Grupo de Trabajo de la Sociedad Latinoamericana de Gastroenterolog\u00eda, Hepatolog\u00eda y Nutrici\u00f3n Pedi\u00e1trica realiz\u00f3 esta revisi\u00f3n de diagn\u00f3stico, tratamiento y seguimiento de la colestasis neonatal, cuyo objetivo es proporcionar una herramienta \u00fatil que permita el diagn\u00f3stico temprano y mejorar el pron\u00f3stico de los ni\u00f1os con colestasis neonatal.<\/jats:p>","DOI":"10.52787\/agl.v52i3.134","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T12:44:43Z","timestamp":1664541883000},"page":"344-354","source":"Crossref","is-referenced-by-count":3,"title":["Colestasis neonatal: revisi\u00f3n narrativa del grupo de trabajo de la Sociedad Latinoamericana de Gastroenterolog\u00eda, Hepatolog\u00eda y Nutrici\u00f3n Pedi\u00e1trica"],"prefix":"10.52787","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6467-953X","authenticated-orcid":false,"given":"Marcela","family":"Godoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6167-0444","authenticated-orcid":false,"given":"Carola","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5087-3075","authenticated-orcid":false,"given":"Felipe","family":"\u00c1lvarez Chavez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5521-7528","authenticated-orcid":false,"given":"Raquel","family":"Borges Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8855-075X","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Botero Osorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8820-8946","authenticated-orcid":false,"given":"Mar\u00eda Valentina","family":"Dolz Aguilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0876-7885","authenticated-orcid":false,"given":"Michelle","family":"Higuera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6614-7529","authenticated-orcid":false,"given":"Reynaldo de Jes\u00fas","family":"Michel Aceves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6108-4784","authenticated-orcid":false,"given":"Gloria","family":"R\u00edos Marcuello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6125-2920","authenticated-orcid":false,"given":"Lorena","family":"Rodr\u00edguez Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Rojo Lillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto E","family":"Soriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7232-7529","authenticated-orcid":false,"given":"Mirta","family":"Ciocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"30608","published-online":{"date-parts":[[2022,9,29]]},"container-title":["Acta Gastroenterol\u00f3gica Latinoamericana"],"original-title":[],"link":[{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/134\/523","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/134\/555","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/134\/555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T12:44:44Z","timestamp":1664541884000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/view\/134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,9,29]]}},"URL":"https:\/\/doi.org\/10.52787\/agl.v52i3.134","relation":{},"ISSN":["2469-1119"],"issn-type":[{"value":"2469-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,29]]}}}