{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T13:17:34Z","timestamp":1747228654764,"version":"3.40.5"},"reference-count":0,"publisher":"Sociedad Argentina de Gastroenterologia","issue":"3","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACTA"],"abstract":"<jats:p>Introducci\u00f3n. El megacolon cr\u00f3nico se manifiesta cl\u00ednicamente como un trastorno de la motilidad que produce en la gran mayor\u00eda de los casos, estre\u00f1imiento, de dif\u00edcil manejo. Seg\u00fan su etiolog\u00eda puede ser cong\u00e9nito, adquirido o idiop\u00e1tico. Objetivo. Describir las caracter\u00edsticas epidemiol\u00f3gicas, cl\u00ednicas y manom\u00e9tricas en una poblaci\u00f3n menor de 40 a\u00f1os con megacolon cr\u00f3nico y estre\u00f1imiento cr\u00f3nica.\nMaterial y m\u00e9todos. Estudio descriptivo de corte transversal. Fueron incluidos 23 pacientes atendidos en el Hospital de Gastroenterolog\u00eda \u201cDr. Bonorino Udaondo\u201d desde marzo de 2019 hasta marzo de 2021. El diagn\u00f3stico de megacolon cr\u00f3nico fue establecido por colon por enema y el de estre\u00f1imiento cr\u00f3nica por los criterios de Roma IV. Se recolectaron datos epidemiol\u00f3gicos y cl\u00ednicos. Los resultados funcionales anorrectales fueron obtenidos a trav\u00e9s de una manometr\u00eda convencional. En todos los casos se indic\u00f3 tratamiento m\u00e9dico para el estre\u00f1imiento.\nResultados. Trece mujeres, mediana de la edad: 21 a\u00f1os (19-30), edad al diagn\u00f3stico: 16 a\u00f1os (13-19). Siete pacientes (30,4%) fueron operados. Causas: 14\/23 idiop\u00e1tico (60,9%), 6\/23 probable enfermedad de Hirschsprung (dos confirmados con biopsia) (26,1%) y secundaria 3\/23 (13%).\u00a0Extensi\u00f3n: 6\/21 megasigma (28,6%), 5\/21 megarrecto (23,8%) y 10\/21 generalizado (47,6%). Los datos manom\u00e9tricos permitieron identificar prevalencia de disinergia del piso pelviano (14\/22 pacientes; 60,9%) y de hiposensorialidad rectal (13\/22; 56,5%). En cinco pacientes (21,7%) el reflejo rectoanal inhibitorio fue negativo. Complicaciones: v\u00f3lvulo, 7\/23 pacientes (30,4%) y fecaloma 12\/23 (52,2%). Tratamiento: polietilenglicol 14\/23 (66,7%), linaclotide 5\/23 (23,8%), prucalopride 13\/23 (61,9%), enemas de Murphy 7\/23 (31,8%) y 18\/23 (81,8%) tratamientos combinados. El riesgo de presentar un fecaloma fue mayor en el megarrecto que en el megacolon (5\/5 vs 3\/10 respectivamente, (p &lt; 0,03). La hiposensorialidad y la disinergia no se asociaron al riesgo de fecaloma (p=NS). Al momento de este estudio, s\u00f3lo una paciente ser\u00e1 operada por no responder al tratamiento m\u00e9dico.\nConclusiones. Todos los pacientes presentan al menos alguna alteraci\u00f3n en la manometr\u00eda. M\u00e1s de la mitad de los pacientes presentaron al menos un fecaloma. El tratamiento m\u00e9dico en pacientes j\u00f3venes ser\u00eda eficaz.<\/jats:p>","DOI":"10.52787\/agl.v52i3.177","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T13:29:37Z","timestamp":1664544577000},"page":"378-384","source":"Crossref","is-referenced-by-count":0,"title":["J\u00f3venes con megacolon cr\u00f3nico: caracter\u00edsticas epidemiol\u00f3gicas, cl\u00ednicas y manom\u00e9tricas"],"prefix":"10.52787","volume":"52","author":[{"given":"Daniela","family":"Milito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Pablo","family":"Stefanolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3687-1177","authenticated-orcid":false,"given":"Irina","family":"Riccobene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8403-4958","authenticated-orcid":false,"given":"Agostina","family":"Pascual Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9312-1597","authenticated-orcid":false,"given":"Marina","family":"Furia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanina","family":"Forestier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3161-6740","authenticated-orcid":false,"given":"Mar\u00eda Paz","family":"Lacuadra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Lumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9641-3437","authenticated-orcid":false,"given":"Horacio","family":"V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucila","family":"Facio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"30608","published-online":{"date-parts":[[2022,9,29]]},"container-title":["Acta Gastroenterol\u00f3gica Latinoamericana"],"original-title":[],"link":[{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/177\/556","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/177\/557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/177\/557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T13:29:37Z","timestamp":1664544577000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/view\/177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,9,29]]}},"URL":"https:\/\/doi.org\/10.52787\/agl.v52i3.177","relation":{},"ISSN":["2469-1119"],"issn-type":[{"type":"print","value":"2469-1119"}],"subject":[],"published":{"date-parts":[[2022,9,29]]}}}