{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T13:17:35Z","timestamp":1747228655670,"version":"3.40.5"},"reference-count":0,"publisher":"Sociedad Argentina de Gastroenterologia","issue":"3","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACTA"],"abstract":"<jats:p>La amiloidosis comprende un grupo heterog\u00e9neo de enfermedades infiltrativas caracterizadas por el dep\u00f3sito extracelular de fibrillas proteicas insolubles. El tubo digestivo puede afectarse en cualquier sector de forma directa o por infiltraci\u00f3n del sistema nervioso aut\u00f3nomo. Los sectores m\u00e1s frecuentemente involucrados son el colon descendente y el sigmoides. El diagn\u00f3stico es histol\u00f3gico mediante tinci\u00f3n con Rojo Congo. La colitis isqu\u00e9mica es la patolog\u00eda isqu\u00e9mica m\u00e1s frecuente del tracto gastrointestinal. La mayor\u00eda de las veces es transitoria y reversible, siendo el colon izquierdo el sector involucrado con m\u00e1s frecuencia. Las manifestaciones cl\u00ednicas son inespec\u00edficas y dependen tanto del grado de isquemia como de los sitios afectados. La videocolonoscop\u00eda es considerada el patr\u00f3n oro para el diagn\u00f3stico. La distribuci\u00f3n topogr\u00e1fica de las lesiones suele ser territorial, segmentaria y parcheada, seg\u00fan los vasos ocluidos. La ausencia de hallazgos patogn\u00f3micos para el diagn\u00f3stico de colitis isqu\u00e9mica hace dif\u00edcil su determinaci\u00f3n en el contexto de comorbilidades como la amiloidosis, ya que esta enfermedad puede tener la misma presentaci\u00f3n cl\u00ednica y endosc\u00f3pica. La isquemia no s\u00f3lo constituye uno de sus mecanismos fisiopatol\u00f3gicos de lesi\u00f3n intestinal, sino que tambi\u00e9n puede ser consecuencia de una afectaci\u00f3n sist\u00e9mica independiente de la infiltraci\u00f3n col\u00f3nica. Se describe y discute el caso de un paciente de 60 a\u00f1os con amiloidosis asociada a cadenas ligeras y debut de colitis, que se presenta con sangrado digestivo bajo y dolor abdominal. Debido al diagn\u00f3stico en diferido de amiloidosis col\u00f3nica y sus caracter\u00edsticas similares a la colitis isqu\u00e9mica, discernir entre ambos result\u00f3 un desaf\u00edo diagn\u00f3stico.<\/jats:p>","DOI":"10.52787\/agl.v52i3.231","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T12:50:39Z","timestamp":1664542239000},"page":"395-401","source":"Crossref","is-referenced-by-count":0,"title":["Colitis isqu\u00e9mica y amiloidosis: un desaf\u00edo diagn\u00f3stico"],"prefix":"10.52787","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4075-4574","authenticated-orcid":false,"given":"Florencia","family":"Benitez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1537-1280","authenticated-orcid":false,"given":"Y\u00e9ssica","family":"Pontet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"30608","published-online":{"date-parts":[[2022,9,29]]},"container-title":["Acta Gastroenterol\u00f3gica Latinoamericana"],"original-title":[],"link":[{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/231\/528","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/231\/545","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/231\/545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T12:50:40Z","timestamp":1664542240000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/view\/231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,9,29]]}},"URL":"https:\/\/doi.org\/10.52787\/agl.v52i3.231","relation":{},"ISSN":["2469-1119"],"issn-type":[{"type":"print","value":"2469-1119"}],"subject":[],"published":{"date-parts":[[2022,9,29]]}}}