{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:15:00Z","timestamp":1790180100519,"version":"4.1.0"},"reference-count":0,"publisher":"Sociedad Argentina de Gastroenterologia","issue":"2","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACTA"],"abstract":"<jats:p>El s\u00edndrome de intestino irritable sigue siendo uno de los trastornos gastrointestinales m\u00e1s comunes observados por los m\u00e9dicos, tanto en la atenci\u00f3n primaria como en la secundaria. Se han logrado avances significativos en la comprensi\u00f3n de su compleja fisiopatolog\u00eda, lo que resulta en su reclasificaci\u00f3n como un trastorno de la interacci\u00f3n intestino-cerebro, en lugar de un trastorno gastrointestinal funcional. La condici\u00f3n afecta a entre el 5% y el 10% de la poblaci\u00f3n y, en la mayor\u00eda de los casos, se caracteriza por tener una evoluci\u00f3n con reca\u00eddas y remisiones. El diagn\u00f3stico se puede hacer sobre la base de la historia cl\u00ednica con un uso limitado y juicioso de las investigaciones, a menos que se presenten s\u00edntomas de alarma, como p\u00e9rdida de peso o sangrado rectal, o que haya antecedentes familiares de enfermedad inflamatoria intestinal o enfermedad cel\u00edaca. Los pilares del tratamiento incluyen la educaci\u00f3n del paciente sobre la afecci\u00f3n, los cambios en la dieta, la fibra soluble y los medicamentos antiespasm\u00f3dicos. Otros tratamientos tienden a estar reservados para personas con s\u00edntomas refractarios e incluyen neuromoduladores centrales, secretagogos intestinales, medicamentos que act\u00faan sobre los receptores opioides o 5-hidroxitriptamina o serotonina (5-HT), o antibi\u00f3ticos m\u00ednimamente absorbidos (todos los cuales se seleccionan de acuerdo con el h\u00e1bito intestinal predominante), as\u00ed como terapias psicol\u00f3gicas. Este consenso es el resultado del trabajo en conjunto de representantes de la Asociaci\u00f3n Centroamericana y del Caribe de Gastroenterolog\u00eda, desarrollado de forma virtual, con el objetivo de presentar una serie de recomendaciones adaptadas a la realidad de la regi\u00f3n y que sirvan de referencia en la pr\u00e1ctica cl\u00ednica.<\/jats:p>","DOI":"10.52787\/agl.v53i2.272","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T21:37:28Z","timestamp":1689197848000},"page":"137-163","source":"Crossref","is-referenced-by-count":3,"title":["Primer consenso centroamericano y del Caribe del s\u00edndrome de intestino irritable"],"prefix":"10.52787","volume":"53","author":[{"given":"Jorge Antonio","family":"Gald\u00e1mez Estrada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0330-3483","authenticated-orcid":false,"given":"Luis","family":"Aguilar 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