{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T13:17:40Z","timestamp":1747228660189,"version":"3.40.5"},"reference-count":0,"publisher":"Sociedad Argentina de Gastroenterologia","issue":"2","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACTA"],"abstract":"<jats:p>El hipertiroidismo es un trastorno caracterizado por el exceso de producci\u00f3n end\u00f3gena de hormonas tiroideas. Es frecuente encontrar alteraciones de la bioqu\u00edmica hep\u00e1tica relacionadas con este diagn\u00f3stico. Dentro de las alteraciones descritas se encuentran la elevaci\u00f3n de la fosfatasa alcalina, la elevaci\u00f3n de las aminotransferasas y, en menor medida, la hiperbilirrubinemia, que suelen ser leves y asintom\u00e1ticas. A continuaci\u00f3n presentamos dos casos de hiperbilirrubinemia directa severa inducidas por hipertiroidismo, uno de ellos con colestasis intrahep\u00e1tica asociada. Ambas son formas de presentaci\u00f3n raras pero bien conocidas de la enfermedad.<\/jats:p>","DOI":"10.52787\/agl.v53i2.294","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T21:37:06Z","timestamp":1689197826000},"page":"181-187","source":"Crossref","is-referenced-by-count":0,"title":["Colestasis intrahep\u00e1tica e hiperbilirrubinemia inducida por hipertiroidismo: Serie de casos"],"prefix":"10.52787","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7296-8449","authenticated-orcid":false,"given":"Juan Pablo","family":"S\u00e1nchez Garc\u00e9s","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1457-6038","authenticated-orcid":false,"given":"Mar\u00eda Clara","family":"Ospino Guerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarny Jos\u00e9","family":"Morales Marenco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Joaqu\u00edn","family":"Moscote Granadillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3692-9917","authenticated-orcid":false,"given":"Raquel Amira","family":"Cano Pe\u00f1aloza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1539-882X","authenticated-orcid":false,"given":"Carlos Mario","family":"Moscote Ter\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"30608","published-online":{"date-parts":[[2023,6,30]]},"container-title":["Acta Gastroenterol\u00f3gica Latinoamericana"],"original-title":[],"link":[{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/294\/634","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/294\/650","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/294\/650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T21:37:07Z","timestamp":1689197827000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/view\/294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,30]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,6,30]]}},"URL":"https:\/\/doi.org\/10.52787\/agl.v53i2.294","relation":{},"ISSN":["2469-1119"],"issn-type":[{"type":"print","value":"2469-1119"}],"subject":[],"published":{"date-parts":[[2023,6,30]]}}}