{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T13:17:45Z","timestamp":1747228665124,"version":"3.40.5"},"reference-count":0,"publisher":"Sociedad Argentina de Gastroenterologia","issue":"2","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACTA"],"abstract":"<jats:p>Introducci\u00f3n. El liquen amiloide es el subtipo m\u00e1s com\u00fan de amiloidosis cut\u00e1nea y se caracteriza por la presencia de p\u00e1pulas y placas asociadas con prurito, localizadas en pantorrillas, cara anterior de muslos e, infrecuentemente, en antebrazos. La colangitis biliar primaria es una enfermedad autoinmune del h\u00edgado caracterizada por una colangitis linfoc\u00edtica destructiva y la presencia de anticuerpos espec\u00edficos antimitocondriales, que condicionan lesi\u00f3n biliar, colestasis y fibrosis hep\u00e1tica progresiva.\nPresentaci\u00f3n de caso. Paciente masculino de 39 a\u00f1os con fototipo IV, que acudi\u00f3 a valoraci\u00f3n por presentar en una ocasi\u00f3n v\u00f3mito borraceo y un episodio de evacuaci\u00f3n mel\u00e9nica de escasa cantidad. Durante la exploraci\u00f3n f\u00edsica, se destac\u00f3 la presencia de p\u00e1pulas hipercr\u00f3micas diseminadas. Se identific\u00f3 un patr\u00f3n colest\u00e1sico con hiperbilirrubinemia a expensas de bilirrubina directa, elevaci\u00f3n de la gamma glutamil transferasa, elevaci\u00f3n de la fosfatasa alcalina, con enzimas hep\u00e1ticas en valores normales; adem\u00e1s, no se identific\u00f3 serolog\u00eda positiva para hepatitis A, B y C. Los anticuerpos antimitocondriales fueron positivos por inmunofluorescencia (1:320). Se tom\u00f3 una biopsia de piel en la que se observ\u00f3 la presencia de hiperqueratosis laminar en estrato c\u00f3rneo y epidermis con acantosis moderada irregular, engrosamiento de procesos interpapilares e hiperpigmentaci\u00f3n de la capa basal.\n Discusi\u00f3n. La asociaci\u00f3n entre amiloidosis cut\u00e1nea primaria localizada y colangitis biliar primaria se ha documentado en pocas ocasiones.<\/jats:p>","DOI":"10.52787\/agl.v54i2.369","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T14:05:38Z","timestamp":1721311538000},"page":"196-201","source":"Crossref","is-referenced-by-count":0,"title":["Liquen amiloide generalizado asociado a colangitis biliar primaria: reporte de caso"],"prefix":"10.52787","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0563-9671","authenticated-orcid":false,"given":"Edwin Jes\u00fas","family":"Pardo Escalera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid Dzoara","family":"Fuentes Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7554-9685","authenticated-orcid":false,"given":"Jos\u00e9 Cruz","family":"Mendoza Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"30608","published-online":{"date-parts":[[2024,7,1]]},"container-title":["Acta Gastroenterol\u00f3gica Latinoamericana"],"original-title":[],"link":[{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/369\/770","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/369\/760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/369\/760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T14:05:39Z","timestamp":1721311539000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/view\/369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,6,30]]}},"URL":"https:\/\/doi.org\/10.52787\/agl.v54i2.369","relation":{},"ISSN":["2469-1119"],"issn-type":[{"type":"print","value":"2469-1119"}],"subject":[],"published":{"date-parts":[[2024,7,1]]}}}