{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T18:10:13Z","timestamp":1735582213130,"version":"3.32.0"},"reference-count":0,"publisher":"Sociedad Argentina de Gastroenterologia","issue":"4","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACTA"],"abstract":"<jats:p>La colitis ulcerosa es una enfermedad inflamatoria cr\u00f3nica que puede presentarse con diferentes grados de severidad. La forma aguda grave ocurre hasta en el 25% de los pacientes y su diagn\u00f3stico es importante para el tratamiento oportuno y la identificaci\u00f3n de las complicaciones. Hasta el momento, las gu\u00edas de pr\u00e1ctica cl\u00ednica sugieren el tratamiento con corticoides como primera l\u00ednea, infliximab o ciclosporina como segunda l\u00ednea y, en el caso de falla terap\u00e9utica, resoluci\u00f3n quir\u00fargica. Presentamos el caso cl\u00ednico de una paciente de 22 a\u00f1os con colitis ulcerosa aguda grave como debut de la enfermedad, refractaria al tratamiento con corticoides e infliximab, en la que se realiz\u00f3 tratamiento con tofacitinib como terapia de rescate. Presentamos el caso cl\u00ednico de una paciente de 22 a\u00f1os con colitis ulcerosa aguda grave como debut de enfermedad, refractaria al tratamiento con corticoides e infliximab, en la que se realiz\u00f3 tratamiento con tofacitinib como terapia de rescate.\u00a0\u00a0<\/jats:p>","DOI":"10.52787\/agl.v54i4.406","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T17:35:17Z","timestamp":1735580117000},"page":"336-340","source":"Crossref","is-referenced-by-count":0,"title":["Tofacitinib como tratamiento de rescate en una paciente con colitis ulcerosa aguda grave refractaria a corticoides e infliximab. Reporte de un caso"],"prefix":"10.52787","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5615-832X","authenticated-orcid":false,"given":"Camila","family":"Briz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5514-7871","authenticated-orcid":false,"given":"Agust\u00edn","family":"Di Santo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1599-4680","authenticated-orcid":false,"given":"Federico","family":"Cassella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"30608","published-online":{"date-parts":[[2024,12,30]]},"container-title":["Acta Gastroenterol\u00f3gica Latinoamericana"],"original-title":[],"link":[{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/406\/810","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/406\/819","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/406\/819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T17:35:17Z","timestamp":1735580117000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/view\/406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,12,30]]}},"URL":"https:\/\/doi.org\/10.52787\/agl.v54i4.406","relation":{},"ISSN":["2469-1119"],"issn-type":[{"value":"2469-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,30]]}}}