{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T19:18:26Z","timestamp":1766517506184,"version":"3.48.0"},"reference-count":0,"publisher":"Sociedad Argentina de Gastroenterologia","issue":"4","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACTA"],"abstract":"<jats:p>Los neuromoduladores se han convertido en una herramienta fundamental dentro de la gastroenterolog\u00eda moderna, especialmente en los trastornos de la interacci\u00f3n cerebro-intestino. Originalmente desarrollados para el manejo de trastornos psiqui\u00e1tricos, estos f\u00e1rmacos han demostrado capacidad para modular el dolor visceral, la hipersensibilidad intestinal y la motilidad digestiva, actuando a trav\u00e9s de mecanismos centrales y perif\u00e9ricos. Entre los neuromoduladores m\u00e1s utilizados se encuentran los antidepresivos tric\u00edclicos, efectivos en la reducci\u00f3n del dolor abdominal; los inhibidores selectivos de la recaptaci\u00f3n de serotonina, \u00fatiles en pacientes con ansiedad o depresi\u00f3n como comorbilidades; y los inhibidores de la recaptaci\u00f3n de serotonina-noradrenalina, empleados en cuadros de dolor visceral con caracter\u00edsticas neurop\u00e1ticas. Otros f\u00e1rmacos como los gabapentinoides, la mirtazapina, la buspirona y ciertos antipsic\u00f3ticos tambi\u00e9n han mostrado beneficios en fenotipos espec\u00edficos. La selecci\u00f3n del f\u00e1rmaco depende del perfil cl\u00ednico del paciente, de sus comorbilidades, su tolerancia y del riesgo de efectos adversos, especialmente en pacientes ancianos y polimedicados. El manejo de los neuromoduladores se caracteriza por el uso de dosis iniciales bajas con incrementos graduales y el seguimiento cercano del paciente. Adem\u00e1s, se recomienda un abordaje multidisciplinario que integre intervenciones no farmacol\u00f3gicas como la terapia cognitivo-conductual, la hipnoterapia dirigida al intestino y programas de mindfulness. Esta combinaci\u00f3n potencia la eficacia cl\u00ednica, reduce el estigma y mejora la calidad de vida, consolidando a los neuromoduladores como parte esencial del tratamiento integral de los trastornos de la interacci\u00f3n cerebro-intestino.<\/jats:p>","DOI":"10.52787\/agl.v55i4.533","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T19:15:27Z","timestamp":1766517327000},"page":"303-316","source":"Crossref","is-referenced-by-count":0,"title":["Utilidad de los neuromoduladores en la pr\u00e1ctica cl\u00ednica: visi\u00f3n del gastroenter\u00f3logo"],"prefix":"10.52787","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7333-6150","authenticated-orcid":false,"given":"Karla Roc\u00edo","family":"Garc\u00eda-Zerme\u00f1o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge E","family":"Aquino-Matus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Jim\u00e9nez Pav\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8478-9659","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Remes-Troche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"30608","published-online":{"date-parts":[[2025,12,23]]},"container-title":["Acta Gastroenterol\u00f3gica Latinoamericana"],"original-title":[],"link":[{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/533\/912","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/533\/928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/533\/928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T19:15:27Z","timestamp":1766517327000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/view\/533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12,23]]}},"URL":"https:\/\/doi.org\/10.52787\/agl.v55i4.533","relation":{},"ISSN":["2469-1119"],"issn-type":[{"value":"2469-1119","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,23]]}}}