{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T19:18:25Z","timestamp":1766517505563,"version":"3.48.0"},"reference-count":0,"publisher":"Sociedad Argentina de Gastroenterologia","issue":"4","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACTA"],"abstract":"<jats:p>Introducci\u00f3n. Los avances en la cirug\u00eda hep\u00e1tica oncol\u00f3gica han mejorado la radicalidad de los procedimientos y ampliado los criterios de resecabilidad. Las transaminasas pueden ser indicadores de injuria hepatocelular postoperatoria.\nObjetivos. Evaluar la relaci\u00f3n entre las transaminasas del primer d\u00eda postoperatorio y la morbimortalidad en las hepatectom\u00edas por patolog\u00eda maligna.\nMateriales y m\u00e9todos. An\u00e1lisis retrospectivo de hepatectom\u00edas por patolog\u00eda maligna entre marzo de 2015 y febrero de 2023. Se evaluaron variables demogr\u00e1ficas, intraoperatorias y postoperatorias. Se determinaron los valores de corte \u00f3ptimos de transaminasas y su relaci\u00f3n con las complicaciones y la mortalidad mediante curvas ROC y c\u00e1lculos de sensibilidad y especificidad.\nResultados. Realizamos 273 hepatectom\u00edas en nuestra instituci\u00f3n, 118 por patolog\u00eda maligna. Hallamos una relaci\u00f3n estad\u00edsticamente significativa entre los valores elevados de las transaminasas en el primer d\u00eda postoperatorio y el desarrollo de la morbimortalidad. Los puntos de corte para predecir mortalidad fueron 856 UI\/L para la transaminasa glut\u00e1mico-oxalac\u00e9tica y 1341 UI\/L para la transaminasa glut\u00e1mico-pir\u00favica (AUC: 0,714 y 0,579, respectivamente), y 530 UI\/L y 257 UI\/L para predecir la ocurrencia de complicaciones (AUC: 0,700 y 0,663). Los valores de transaminasas glut\u00e1mico-oxalac\u00e9tica elevados se asociaron a insuficiencia hep\u00e1tica postoperatoria, con un punto de corte &gt; 856 UI\/L (AUC: 0,834).\nConclusi\u00f3n. Los valores elevados de transaminasas al primer d\u00eda postoperatorio se asociaron con mayor ocurrencia de complicaciones, necesidad de hemoderivados y uso de drogas vasoactivas. Una transaminasa glut\u00e1mico-oxalac\u00e9tica elevada indica un riesgo mayor de insuficiencia hep\u00e1tica postoperatoria y mortalidad a 90 d\u00edas. Las transaminasas son marcadores pron\u00f3sticos \u00fatiles en las hepatectom\u00edas por patolog\u00eda maligna.<\/jats:p>","DOI":"10.52787\/agl.v55i4.547","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T19:15:25Z","timestamp":1766517325000},"page":"358-370","source":"Crossref","is-referenced-by-count":0,"title":["Transaminasas en el primer d\u00eda poshepatectom\u00eda y predicci\u00f3n de resultados en patolog\u00eda maligna"],"prefix":"10.52787","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6504-7406","authenticated-orcid":false,"given":"Lourdes","family":"Mollard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo A","family":"Gasque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5138-0400","authenticated-orcid":false,"given":"Magal\u00ed","family":"Chahdi Beltrame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9087-8703","authenticated-orcid":false,"given":"Marcelo E","family":"Lenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1773-353X","authenticated-orcid":false,"given":"Francisco J","family":"Mattera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4167-8814","authenticated-orcid":false,"given":"Emilio G","family":"Qui\u00f1onez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"30608","published-online":{"date-parts":[[2025,12,23]]},"container-title":["Acta Gastroenterol\u00f3gica Latinoamericana"],"original-title":[],"link":[{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/547\/921","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/547\/935","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/547\/935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T19:15:25Z","timestamp":1766517325000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/view\/547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12,23]]}},"URL":"https:\/\/doi.org\/10.52787\/agl.v55i4.547","relation":{},"ISSN":["2469-1119"],"issn-type":[{"value":"2469-1119","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,23]]}}}