{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:50:11Z","timestamp":1774986611831,"version":"3.50.1"},"reference-count":0,"publisher":"Sociedad Argentina de Gastroenterologia","issue":"1","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACTA"],"abstract":"<jats:p>Introducci\u00f3n. La malnutrici\u00f3n y sarcopenia aumentan la morbi-mortalidad en pacientes cirr\u00f3ticos. La insuficiencia pancre\u00e1tica exocrina agrava el d\u00e9ficit nutricional. \nObjetivo. Evaluar la funci\u00f3n exocrina del p\u00e1ncreas mediante elastasa fecal en pacientes con cirrosis hep\u00e1tica por alcohol y otras causas. \nMateriales y m\u00e9todos. Estudio transversal, descriptivo en pacientes con cirrosis a los que se les realiz\u00f3 una elastasa fecal en el Hospital Cl\u00ednico Universidad de Chile entre febrero de 2016 y julio de 2023. Se evaluaron variables demogr\u00e1ficas, cl\u00ednicas, nutricionales y de sobrevida.\n Resultados. Se estudiaron 85 pacientes, mediana de edad de 60 a\u00f1os. Las etiolog\u00edas m\u00e1s frecuentes fueron consumo de alcohol en 40 (47%) e h\u00edgado graso metab\u00f3lico en 21 (25%). De los 85 pacientes, el 88% present\u00f3 elastasa fecal &gt; a 200 \u00b5g\/g, un 5% 100-199 \u00b5g\/g y un 7% &lt; 100 \u00b5g\/g. La elastasa fecal fue significativamente menor en cirr\u00f3ticos alcoh\u00f3licos versus otras etiolog\u00edas (p = 0,003). De los pacientes con cirrosis por alcohol, un 20% present\u00f3 elastasa fecal &lt; 200 \u00b5g\/g (15% &lt; 100 \u00b5g\/g). Los pacientes que beb\u00edan &gt;20 g\/d\u00eda de alcohol tuvieron elastasa fecal significativamente menor (p = 0,013) que aquellos que beb\u00edan menos. \nConclusi\u00f3n. En pacientes con cirrosis por alcohol, encontramos un 20% de elastasa fecal disminuida. El consumo &gt;20 g\/d\u00eda de alcohol se asocia a menores niveles de elastasa fecal. Considerando que la malnutrici\u00f3n y sarcopenia inciden en el pron\u00f3stico y que la insuficiencia pancre\u00e1tica exocrina puede no ser cl\u00ednicamente evidente, consideramos que podr\u00eda justificarse la medici\u00f3n de elastasa fecal en pacientes con cirrosis por alcohol, en particular cuando existe d\u00e9ficit nutricional.<\/jats:p>","DOI":"10.52787\/agl.v56i1.579","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T18:57:47Z","timestamp":1774983467000},"page":"94-101","source":"Crossref","is-referenced-by-count":0,"title":["Insuficiencia pancre\u00e1tica exocrina en cirrosis hep\u00e1tica: estudio de corte transversal"],"prefix":"10.52787","volume":"56","author":[{"given":"V\u00edctor","family":"Henr\u00edquez Auba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7618-995X","authenticated-orcid":false,"given":"Carmen","family":"Hurtado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1728-7143","authenticated-orcid":false,"given":"Carla","family":"Mancilla Asencio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Herman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Neman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9449-933X","authenticated-orcid":false,"given":"Zolt\u00e1n","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"30608","published-online":{"date-parts":[[2026,3,31]]},"container-title":["Acta Gastroenterol\u00f3gica Latinoamericana"],"original-title":[],"link":[{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/579\/947","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/579\/966","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/579\/966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T18:57:48Z","timestamp":1774983468000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/view\/579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3,31]]}},"URL":"https:\/\/doi.org\/10.52787\/agl.v56i1.579","relation":{},"ISSN":["2469-1119"],"issn-type":[{"value":"2469-1119","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]}}}