{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T02:45:19Z","timestamp":1782873919300,"version":"3.54.5"},"reference-count":0,"publisher":"Sociedad Argentina de Gastroenterologia","issue":"2","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACTA"],"abstract":"<jats:p>Introducci\u00f3n. El c\u00e1ncer colorrectal en adultos menores de 50 a\u00f1os, o c\u00e1ncer colorrectal de inicio temprano, ha mostrado un aumento progresivo en su incidencia a nivel mundial. Este grupo etario habitualmente es excluido de los programas de tamizaje.\nObjetivos. Describir las caracter\u00edsticas epidemiol\u00f3gicas, cl\u00ednicas y los resultados de sobrevida de pacientes con c\u00e1ncer colorrectal de inicio temprano atendidos en un centro de referencia.\nMateriales y m\u00e9todos. Estudio de cohorte retrospectiva que incluy\u00f3 pacientes de hasta 49 a\u00f1os con diagn\u00f3stico histol\u00f3gico de adenocarcinoma colorrectal atendidos entre 2015 y 2024. Se analizaron variables cl\u00ednicas, localizaci\u00f3n tumoral, estadio TNM y supervivencia.\nResultados. Se incluyeron 56 pacientes, con mediana de edad de 42 a\u00f1os (RIC 13,3). La localizaci\u00f3n m\u00e1s frecuente fue colon derecho (32,1%). El 57% present\u00f3 enfermedad en estadio avanzado y 33,9% met\u00e1stasis al diagn\u00f3stico. La mediana de sobrevida global fue de 78 meses, con una sobrevida a 5 a\u00f1os de 59,3%. La presencia de met\u00e1stasis al diagn\u00f3stico se asoci\u00f3 de manera independiente con peor sobrevida (HR 2,38; IC 95% 1,08 \u2013 5,26; p = 0,031), y la edad menor de 40 a\u00f1os mostr\u00f3 una tendencia a peor pron\u00f3stico (HR 2,17; IC 95% 0,95 \u2013 5,00; p = 0,065).\nConclusi\u00f3n. Si bien el colon derecho fue la localizaci\u00f3n individual m\u00e1s frecuente, no se observ\u00f3 un predominio claro de ninguna localizaci\u00f3n tumoral. La cohorte se caracteriz\u00f3 por una elevada proporci\u00f3n de enfermedad avanzada al diagn\u00f3stico y una supervivencia global menor que la reportada en otras series. La enfermedad metast\u00e1sica fue el principal determinante de la sobrevida, y los pacientes menores de 40 a\u00f1os mostraron una tendencia a peor evoluci\u00f3n.<\/jats:p>","DOI":"10.52787\/agl.v56i2.622","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T02:05:23Z","timestamp":1782871523000},"page":"216-225","source":"Crossref","is-referenced-by-count":0,"title":["C\u00e1ncer colorrectal de inicio temprano: caracter\u00edsticas epidemiol\u00f3gicas, cl\u00ednicas y an\u00e1lisis de sobrevida en una cohorte hospitalaria"],"prefix":"10.52787","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9504-166X","authenticated-orcid":false,"given":"Rub\u00e9n","family":"Balmaceda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9783-8383","authenticated-orcid":false,"given":"Tom\u00e1s Valent\u00edn","family":"D\u2019Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn M\u00e1ximo","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn","family":"Galvarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Affronti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Kerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"30608","published-online":{"date-parts":[[2026,6,30]]},"container-title":["Acta Gastroenterol\u00f3gica Latinoamericana"],"original-title":[],"link":[{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/622\/979","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/622\/995","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/622\/995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T02:05:23Z","timestamp":1782871523000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/view\/622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6,30]]}},"URL":"https:\/\/doi.org\/10.52787\/agl.v56i2.622","relation":{},"ISSN":["2469-1119"],"issn-type":[{"value":"2469-1119","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]}}}