{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:08:32Z","timestamp":1790863712384,"version":"4.1.0"},"reference-count":0,"publisher":"Sociedad Argentina de Gastroenterologia","issue":"3","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACTA"],"abstract":"<jats:p>Introducci\u00f3n. El carcinoma hepatocelular es la neoplasia hep\u00e1tica primaria m\u00e1s frecuente. La vigilancia mediante ecograf\u00eda abdominal y determinaci\u00f3n de alfafetoprote\u00edna permite su detecci\u00f3n en estadios tempranos. El objetivo de este estudio fue evaluar la adherencia a la vigilancia del carcinoma hepatocelular en pacientes con cirrosis y analizar su asociaci\u00f3n con el estadio tumoral, la funci\u00f3n hep\u00e1tica y los niveles de alfafetoprote\u00edna al momento del diagn\u00f3stico.\n M\u00e9todos. Estudio retrospectivo que incluy\u00f3 a pacientes con cirrosis y diagn\u00f3stico de carcinoma hepatocelular entre 2000 y 2024. Se consider\u00f3 adherente al paciente que hubiera realizado al menos un control de vigilancia mediante ecograf\u00eda abdominal y alfafetoprote\u00edna dentro de los seis meses previos al diagn\u00f3stico. Se analizaron variables demogr\u00e1ficas, etiolog\u00eda, funci\u00f3n hep\u00e1tica, estadio seg\u00fan Barcelona Clinic Liver Cancer (BCLC) y niveles de alfafetoprote\u00edna.\nResultados. Fueron incluidos 121 pacientes; la edad media fue de 64,3 \u00b1 10,6 a\u00f1os y el 73,6% correspondi\u00f3 al sexo masculino. El 33% (40\/121) cumpli\u00f3 criterios de adherencia. Los pacientes adherentes presentaron una mayor proporci\u00f3n de Child-Pugh A (60% vs. 24,7%; p &lt; 0,001), fueron diagnosticados con mayor frecuencia en estadio BCLC A (37,5% vs. 17,3%; p = 0,023) y mostraron, de manera descriptiva, una menor mediana de AFP (7 vs 21 ng\/mL). Sin embargo, en el an\u00e1lisis multivariado ajustado por edad, sexo, funci\u00f3n hep\u00e1tica, etiolog\u00eda y a\u00f1o de diagn\u00f3stico, la asociaci\u00f3n entre adherencia y diagn\u00f3stico en estadio BCLC A no alcanz\u00f3 significaci\u00f3n estad\u00edstica.\n Conclusiones. La adherencia a la vigilancia del carcinoma hepatocelular fue baja. En el an\u00e1lisis no ajustado, los pacientes adherentes fueron diagnosticados con mayor frecuencia en estadio BCLC A y mostraron, de manera descriptiva, una menor mediana de alfafetoprote\u00edna. La asociaci\u00f3n entre adherencia y diagn\u00f3stico en estadio BCLC A no mantuvo significaci\u00f3n estad\u00edstica tras el ajuste por variables cl\u00ednicas relevantes.<\/jats:p>","DOI":"10.52787\/agl.v56i3.661","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:08:42Z","timestamp":1790824122000},"page":"324-331","source":"Crossref","is-referenced-by-count":0,"title":["Adherencia a la vigilancia del carcinoma hepatocelular y su asociaci\u00f3n con el estadio tumoral al diagn\u00f3stico: experiencia de un hospital universitario"],"prefix":"10.52787","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7208-0615","authenticated-orcid":false,"given":"Gabriel Adri\u00e1n","family":"Mari\u00f1o Camacho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4336-9716","authenticated-orcid":false,"given":"Jonathan David","family":"Salmon Pico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Bortot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9389-9873","authenticated-orcid":false,"given":"Andrea","family":"Curia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4286-2373","authenticated-orcid":false,"given":"Cielo","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9351-9714","authenticated-orcid":false,"given":"Gabriela","family":"Quintero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6043-7218","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Sanguinetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8066-2244","authenticated-orcid":false,"given":"Esteban","family":"Gonz\u00e1lez Ballerga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"30608","published-online":{"date-parts":[[2026,9,30]]},"container-title":["Acta Gastroenterol\u00f3gica Latinoamericana"],"original-title":[],"link":[{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/661\/1003","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/661\/1026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/download\/661\/1026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:47:04Z","timestamp":1790862424000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaojs.org.ar\/ojs\/index.php\/acta\/article\/view\/661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9,30]]}},"URL":"https:\/\/doi.org\/10.52787\/agl.v56i3.661","relation":{},"ISSN":["2469-1119"],"issn-type":[{"value":"2469-1119","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]}}}