{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:28:44Z","timestamp":1777328924914,"version":"3.51.4"},"reference-count":0,"publisher":"Rila Publications Ltd","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acute Med J"],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:p>Carfilzomib has shown excellent outcomes for relapsed Multiple Myeloma. There have been increasing reports on cardiovascular adverse events. However, reports on severe pulmonary adverse events are rare. Our patient was a 79-year-old female, undergoing fourth-line therapy with Carfilzomib. At 24h after first administration, the patient was admitted to the emergency room complaining of dyspnoea. After a full recovery, the patient was re-evaluated. Since echocardiography showed normal cardiac function, Carfilzomib was re-initiated. At 24h after administration, the patient was re-admitted to the emergency room with severe dyspnoea, meeting criteria for ARDS. Despite mechanical ventilation, the patient developed cardiac arrest. Resuscitation was unsuccessful. Although patients might fully recover from a first episode of Carfilzomib-induced pulmonary toxicity, re-initiation of Carfilzomib is not recommended.<\/jats:p>","DOI":"10.52964\/amja.0880","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T06:49:44Z","timestamp":1643179784000},"page":"286-289","source":"Crossref","is-referenced-by-count":4,"title":["Fatal pulmonary toxicity following Carfilzomib administration"],"prefix":"10.52964","volume":"20","author":[{"name":"MD, Department of Cardiology, Central defense hospital, Madrid, Spain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Marschall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Carlos","family":"de la Flor Merino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"MD, Department of Nephrology, Central defense hospital, Madrid, Spain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Linares Gravalos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"MD, Department of Nephrology, Central defense hospital, Madrid, Spain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"30823","published-online":{"date-parts":[[2021,10,1]]},"container-title":["Acute Medicine Journal"],"original-title":[],"deposited":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T06:49:54Z","timestamp":1643179794000},"score":1,"resource":{"primary":{"URL":"https:\/\/acutemedjournal.co.uk\/fatal-pulmonary-toxicity-following-carfilzomib-administration"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,10,1]]},"published-print":{"date-parts":[[2021,10,1]]}},"URL":"https:\/\/doi.org\/10.52964\/amja.0880","relation":{},"ISSN":["1747-4884"],"issn-type":[{"value":"1747-4884","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10,1]]}}}