{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T15:04:03Z","timestamp":1746716643178},"reference-count":0,"publisher":"Rila Publications Ltd","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acute Med"],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:p>High anion gap metabolic acidosis (HAGMA) is a common diagnosis in the emergency department, which requires a systematic work-up in order to identify and treat the underlying cause. We present an unusual case of HAGMA due to 5-oxoproline accumulation caused by prolonged treatment with both acetaminophen (paracetamol) and flucloxacillin. This paper describes the diagnostic work-up of HAGMA and emphasizes on the approach and initial treatment in case the underlying etiology is unclear.<\/jats:p>","DOI":"10.52964\/amja.0892","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T17:48:01Z","timestamp":1648489681000},"page":"47-49","source":"Crossref","is-referenced-by-count":4,"title":["5-Oxoproline acidosis caused by acetaminophen and flucloxacillin treatment \u2013 a case report"],"prefix":"10.52964","volume":"21","author":[{"name":"MD, PhD, Department of Internal Medicine, Zuyderland Medical Centre, Sittard\/ Heerlen, The Netherlands","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"van Montfort","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Helmich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"PhD, Laboratory for Clinical Chemistry and Haematology, Zuyderland Medical Centre, Sittard\/ Heerlen, The Netherlands","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GJM","family":"Mostard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"MD, Department of Internal Medicine, Zuyderland Medical Centre, Sittard\/ Heerlen, The Netherlands","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DJL","family":"van Twist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"MD, PhD, Department of Internal Medicine, Zuyderland Medical Centre, Sittard\/ Heerlen, The Netherlands","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"30823","published-online":{"date-parts":[[2022,1,1]]},"container-title":["Acute Medicine Journal"],"original-title":[],"deposited":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T17:48:21Z","timestamp":1648489701000},"score":1,"resource":{"primary":{"URL":"https:\/\/acutemedjournal.co.uk\/5-oxoproline-acidosis-caused-by-acetaminophen-and-flucloxacillin-treatment-a-case-report\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,1]]},"published-print":{"date-parts":[[2022,1,1]]}},"URL":"https:\/\/doi.org\/10.52964\/amja.0892","relation":{},"ISSN":["1747-4884"],"issn-type":[{"type":"print","value":"1747-4884"}],"subject":[],"published":{"date-parts":[[2022,1,1]]}}}