{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:23:38Z","timestamp":1787243018730,"version":"build-2736575974"},"reference-count":0,"publisher":"Rila Publications Ltd","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acute Med"],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:p>Intoxications with sodium azide are rare and in almost all cases lethal in doses above 700 mg or 10mg\/kg. We report a case of a patient who ingested 2 grams of sodium azide as a suicide attempt. Sodium azide irreversible blocks cytochrome C oxidase by inhibiting oxidative phosphorylation leading to cell death. There is currently no antidote available. Our patient was treated with a range of therapies, on site, in the emergency department and in the intensive care unit, such as sodium thiosulphate, methylene blue, intralipid, extensive gastric lavage, whole bowel irrigation combined with pro-kinetics, hydroxocobalamin and exchange transfusion. During the clinical course the patient developed cardiac failure, for which veno-arterial ECMO and an intra-aortic balloon pump was placed. However, cardiac function did not recover, leading to discontinuation of treatment after 7 days. As literature on sodium azide intoxication is scarce, we conducted a review to present potential treatment options.<\/jats:p>","DOI":"10.52964\/amja.0903","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T20:13:46Z","timestamp":1655756026000},"page":"86-95","source":"Crossref","is-referenced-by-count":7,"title":["Potential therapies for sodium azide intoxication; a case report and review of the literature"],"prefix":"10.52964","volume":"21","author":[{"name":"Erasmus University Medical Center, Erasmus MC, Rotterdam, the Netherlands, Department of Anesthesiology Leiden University Medical Center, Leiden, the Netherlands, Department of Anesthesiology","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.T. A.","family":"Groeneveld","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"van Hoeven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Erasmus University Medical Center, Erasmus MC, Rotterdam, the Netherlands, Department of Internal Medicine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.S.","family":"van der Crabben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Erasmus University Medical Center, Erasmus MC, Rotterdam, the Netherlands, Department of Anesthesiology","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.A.","family":"den Uil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Erasmus University Medical Center, Erasmus MC, Rotterdam, the Netherlands, Department of Cardiology Maasstad Hospital, Rotterdam, the Netherlands, Department of Intensive Care Medicine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bethlehem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Erasmus University Medical Center, Erasmus MC, Rotterdam, the Netherlands, Department of Hospital Pharmacy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Alsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Leiden University Medical Center, Leiden, the Netherlands, Department of Anesthesiology","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"30823","published-online":{"date-parts":[[2022,4,1]]},"container-title":["Acute Medicine Journal"],"original-title":[],"deposited":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T20:13:53Z","timestamp":1655756033000},"score":1,"resource":{"primary":{"URL":"https:\/\/acutemedjournal.co.uk\/potential-therapies-for-sodium-azide-intoxication-a-case-report-and-review-of-the-literature\/#article-text"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,4,1]]},"published-print":{"date-parts":[[2022,4,1]]}},"URL":"https:\/\/doi.org\/10.52964\/amja.0903","relation":{},"ISSN":["1747-4884"],"issn-type":[{"value":"1747-4884","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,1]]}}}