{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:06:40Z","timestamp":1760242000586,"version":"build-2065373602"},"reference-count":0,"publisher":"Rila Publications Ltd","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acute Med"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Background: Sepsis, a devastating syndrome of organ dysfunction triggered by a dysregulated host response to infection, remains a leading cause of global mortality. Statins, renowned for lipid-lowering, also exhibit potent anti-inflammatory and endothelial-stabilizing properties, offering a theoretical advantage in the septic milieu. This study investigated whether adjunctive atorvastatin could improve survival and modulate key sepsis-related outcomes.\nMethods: In this open-label, randomized controlled trial conducted in the acute medical unit of a tertiary academic center, adult patients with sepsis(defined as suspected infection plus a SOFA score increment of \u22652) were allocated to receive either standard sepsis management plus daily oral atorvastatin 20mg or standard management alone for up to 28 days. The primary endpoint was 28-day all-cause mortality. Secondary endpoints included requirements for organ support, duration of hospitalization, and kinetic changes in C-reactive protein(CRP), procalcitonin(PCT), and lactate. Analysis adhered to intention-to-treat principles.\nResults: Sixty-eight patients were randomized(36 atorvastatin, 32 control). While 28-day mortality trended lower in the atorvastatin arm(36% vs. 56% in controls; Risk Difference -20%, 95% CI -45% to 5%), this difference did not achieve statistical significance(p=0.10). Similarly, no significant benefits were observed in organ support needs or hospital stay. Critically, atorvastatin administration led to a significant and more pronounced reduction in both procalcitonin(median change -8 vs 0 ng\/ml, p=0.005) and lactate levels(median change -0.95 vs -0.62 mmol\/l, p=0.048) by day 7.\nConclusion: While adjunctive atorvastatin did not demonstrably reduce 28-day mortality in this sepsis cohort, its significant impact on attenuating procalcitonin and lactate levels suggests a beneficial modulation of underlying inflammatory and metabolic derangements.<\/jats:p>","DOI":"10.52964\/amja.1004","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:29:12Z","timestamp":1760196552000},"page":"27-34","source":"Crossref","is-referenced-by-count":0,"title":["Adjunctive Atorvastatin for Sepsis in the Acute Medical Unit: A Randomized Controlled Trial"],"prefix":"10.52964","volume":"24","author":[{"name":"MBBS, Junior Resident, Division of Acute Care and Emergency Medicine, Department of Internal Medicine,  Post Graduate Institute of Medical Education and Research,  Chandigarh, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ch Adrees","family":"Rashid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohan","family":"Kumar H","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"MD, Associate  Professor, Division of Acute Care and Emergency Medicine, Department of Internal Medicine,  Post Graduate Institute of Medical Education and Research,  Chandigarh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandip Singh","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"MD, Associate  Professor, Division of Acute Care and Emergency Medicine, Department of Internal Medicine,  Post Graduate Institute of Medical Education and Research,  Chandigarh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Saroch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"MD, Additional Professor, Division of Acute Care and Emergency Medicine, Department of Internal Medicine,  Post Graduate Institute of Medical Education and Research,  Chandigarh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navneet","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"MD, Professor, Division of Acute Care and Emergency Medicine, Department of Internal Medicine,  Post Graduate Institute of Medical Education and Research,  Chandigarh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saurabh Chandrabhan","family":"Sharda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"MD, Associate  Professor, Division of Acute Care and Emergency Medicine, Department of Internal Medicine,  Post Graduate Institute of Medical Education and Research,  Chandigarh, India","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"30823","published-online":{"date-parts":[[2025,1]]},"container-title":["Acute Medicine Journal"],"original-title":[],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:29:13Z","timestamp":1760196553000},"score":1,"resource":{"primary":{"URL":"https:\/\/acutemedjournal.co.uk\/adjunctive-atorvastatin-for-sepsis-in-the-acute-medical-unit-a-randomized-controlled-trial\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]},"published-print":{"date-parts":[[2025,1]]}},"URL":"https:\/\/doi.org\/10.52964\/amja.1004","relation":{},"ISSN":["1747-4884"],"issn-type":[{"value":"1747-4884","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]}}}