{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:12:26Z","timestamp":1785402746667,"version":"3.56.0"},"reference-count":13,"publisher":"Open Medical Publishing","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"\n Background<\/jats:title>\n Spinal fusion surgeries remain a successful treatment for degenerative disc disease. While autograft is considered the gold standard bone graft, synthetic bone void fillers are increasingly used to limit donor site morbidity while giving sufficient graft volume.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This retrospective clinical study evaluates MagnetOs Easypack Putty\n TM<\/jats:sup>\n as a standalone graft without autograft in interbody fusion. An independent radiologist blinded to the clinical status provided evaluation of computed tomography (CT) images obtained at 12 months and graded each treated level based on the Brantigan-Steffee-Fraser (BSF) Classification. Twenty subjects were enrolled in the study. A total of 36 spinal levels were treated with an average of 1.8 levels per subject (L2-L3 to L5-S1).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The primary endpoint of CT-based fusion was 94.4% (34\/36 levels) based on the presence of bridging bone or locked pseudoarthrosis at 12 months. The high fusion rate was accompanied by consistent improvement in pain scores. Visual analogue scale (VAS) pain scores decreased an average of 25% from 5.3\/10 pre-operatively to 2.8\/10 at 12 months post-operative, and all subjects who reported pre-operative back or leg pain reported improved pain post-operatively. Although the patient population included risk factors and comorbidities, the fusion rate remained high, and no device-related adverse events (AEs) were observed.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The high fusion rate and favorable safety profile support the performance of MagnetOs Easypack Putty for standalone use without autograft in interbody fusion procedures.<\/jats:p>\n <\/jats:sec>","DOI":"10.52965\/001c.133986","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T12:30:36Z","timestamp":1745929836000},"source":"Crossref","is-referenced-by-count":2,"title":["A retrospective review of MagnetOs Easypack Putty\n TM<\/sup>\n bone graft used standalone in transforaminal lumbar interbody fusion"],"prefix":"10.52965","volume":"17","author":[{"given":"Justin","family":"Davis","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05kg11974","id-type":"ROR","asserted-by":"publisher"}],"name":"The University of Kansas Health System","department":["Neurosurgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Everist","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05kg11974","id-type":"ROR","asserted-by":"publisher"}],"name":"The University of Kansas Health System","department":["Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8236-7281","authenticated-orcid":true,"given":"Casey","family":"Hatfield","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04byqhw79","id-type":"ROR","asserted-by":"publisher"}],"name":"Kuros Biosciences (Switzerland)","department":["Clinical, Medical, and Scientific Affairs"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Sage","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04byqhw79","id-type":"ROR","asserted-by":"publisher"}],"name":"Kuros Biosciences (Switzerland)","department":["Clinical, Medical, and Scientific Affairs"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"30777","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1007\/s00586-022-07275-y","article-title":"Ceramic bone graft substitute vs autograft in XLIF: a prospective randomized single-center evaluation of radiographic and clinical outcomes","volume":"31","author":"C. M. Menezes","year":"2022","journal-title":"Eur Spine J"},{"key":"ref2","first-page":"358","article-title":"Twelve month results of a multi-center, blinded, pilot study of a novel peptide (B2A) in promoting lumbar spine fusion","volume":"22","author":"Z. Sardar","year":"2015","journal-title":"JNS Spine"},{"issue":"3601","key":"ref3","article-title":"Effection of Ratios of Autograft Area on Fusion Rate in TLIF","volume":"7","author":"Y. Sun","year":"2022","journal-title":"Clin Surg"},{"issue":"0","key":"ref4","article-title":"Neurosurg","volume":"00","author":"A. Parajon","year":"2017"},{"issue":"329","key":"ref5","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1097\/00003086-199608000-00037","article-title":"Complications of iliac crest bone graft harvesting","author":"E. D. Arrington","year":"1996","journal-title":"Clin Orthop Relat Res"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/01.bsd.0000112045.36255.83","article-title":"Iliac crest bone graft donor site pain after anterior lumbar interbody fusion: a prospective patient satisfaction outcome assessment","volume":"18","author":"R. C. Sasso","year":"2005","journal-title":"J Spinal Disord Tech"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1097\/00005131-198909000-00002","article-title":"Morbidity at bone graft donor sites","volume":"33","author":"E. M. Younger","year":"1989","journal-title":"J Orthop Trauma"},{"issue":"6","key":"ref8","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/0278-2391(91)90335-j","article-title":"Comparative anatomic study of anterior and posterior iliac crests as donor sites","volume":"49","author":"M. B. Hall","year":"1991","journal-title":"J Oral Maxillofac Surg"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e1039","DOI":"10.1002\/jsp2.1039","article-title":"Biphasic calcium phosphate with submicron surface topography in an Ovine model of instrumented posterolateral spinal fusion","volume":"1","author":"L. A. Van Dijk","year":"2018","journal-title":"JOR Spine"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"60","DOI":"10.22203\/eCM.v037a05","article-title":"Accelerated bone formation by biphasic calcium phosphate with a novel sub-micron surface topography","volume":"37","author":"R. Duan","year":"2019","journal-title":"ECM"},{"issue":"6","key":"ref11","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.spinee.2018.01.028","article-title":"Posterolateral fusion (PLF) versus transforaminal lumbar interbody fusion (TLIF) for spondylolisthesis: a systemic review and meta-analysis","volume":"18","author":"J. M. Levin","year":"2018","journal-title":"Spine J"},{"key":"ref12","article-title":"An inception cohort study of patients in a military clinic treated for lower back pain with lumbar fusion and SIGNAFUSE\u00ae with a systematic review of the literature","author":"A. J. Bevevino","year":"2018","journal-title":"Surg Case Rep"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-015-3929-7","article-title":"Fusion rate following extreme lateral lumbar interbody fusion","author":"P. Berjano","year":"2015","journal-title":"Eur Spine J"}],"container-title":["Orthopedic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/orthopedicreviews.openmedicalpublishing.org\/article\/133986-a-retrospective-review-of-magnetos-easypack-putty-tm-bone-graft-used-standalone-in-transforaminal-lumbar-interbody-fusion","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T00:59:38Z","timestamp":1761440378000},"score":1,"resource":{"primary":{"URL":"https:\/\/orthopedicreviews.openmedicalpublishing.org\/article\/133986-a-retrospective-review-of-magnetos-easypack-putty-tm-bone-graft-used-standalone-in-transforaminal-lumbar-interbody-fusion"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":13,"URL":"https:\/\/doi.org\/10.52965\/001c.133986","relation":{},"ISSN":["2035-8164"],"issn-type":[{"value":"2035-8164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,29]]}}}