{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:31:42Z","timestamp":1793323902910,"version":"4.5.0"},"reference-count":17,"publisher":"Open Medical Publishing","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"\n Background<\/jats:title>\n Degenerative lumbar spinal stenosis is a leading cause of disability, and lumbar interbody fusion (LIF) is a common surgical option. However, pseudarthrosis and suboptimal fusion remain important limitations. Porous titanium cages with biologically active hydrogels may enhance osteointegration compared with PEEK implants.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This single-centre prospective randomized trial included 50 patients with lumbar stenosis undergoing single-level TLIF. Patients were allocated 1:1 to Group I (trabecular Ti-6Al-4V cage with autologous bone and stromal-vascular fraction\u2013based heparin-conjugated fibrin hydrogel) or Group II (PEEK cage with autologous bone only). Follow-up was 12 months. Primary endpoints were CT-based fusion at 12 months (Tan classification) and bone density within the cage region (Hounsfield units, HU). Secondary outcomes included pain (VAS), disability (ODI), implant subsidence\/migration, operative parameters, and complications.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Baseline demographic and clinical characteristics and intraoperative blood loss were comparable between groups. Mean HU values were significantly higher in Group I at 3\u20134, 6 and 12 months (428.0\u00b168.6 vs 388.8\u00b146.6, p=0.0228; 527.5\u00b181.8 vs 466.4\u00b152.7, p=0.0031; 594.8\u00b178.7 vs 521.0\u00b175.0, p=0.0014). Complete fusion (Tan grade 1) at 12 months was achieved in 68% of Group I versus 32% of Group II patients (p=0.0227). Group I also showed greater VAS and ODI improvement at all postoperative time points. No intraoperative complications or hydrogel-related adverse events were observed.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n A trabecular titanium cage combined with autologous bone and SVF-based hydrogel appears safe and more effective than a PEEK cage with autograft, providing superior radiological fusion and faster recovery at 12 months<\/jats:p>\n <\/jats:sec>","DOI":"10.52965\/001c.159611","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:34:37Z","timestamp":1775090077000},"source":"Crossref","is-referenced-by-count":0,"title":["Osteointegration and Fusion After TLIF: Trabecular Titanium Cage with SVF-Hydrogel Compared with PEEK Cage."],"prefix":"10.52965","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7304-4261","authenticated-orcid":false,"given":"Murat U.","family":"Baidarbekov","sequence":"first","affiliation":[{"name":"National Scientific Center of Traumatology and Orthopedics named after Academician N.D. Batpenov, Astana, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7188-1369","authenticated-orcid":true,"given":"Zhangir N.","family":"Ipmagambetov","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024cz2s53","id-type":"ROR","asserted-by":"publisher"}],"name":"Karaganda Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3033-6317","authenticated-orcid":false,"given":"Nailya","family":"DeLellis","sequence":"additional","affiliation":[{"name":"Health Administration Program, School of Health Sciences, Central Michigan University, Mount Pleasant, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7318-3739","authenticated-orcid":false,"given":"Olzhas S.","family":"Bekarissov","sequence":"additional","affiliation":[{"name":"National Scientific Center of Traumatology and Orthopedics named after Academician N.D. Batpenov, Astana, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5292-4821","authenticated-orcid":false,"given":"Margulan S.","family":"Abdikalikov","sequence":"additional","affiliation":[{"name":"National Scientific Center of Traumatology and Orthopedics named after Academician N.D. Batpenov, Astana, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3583-6871","authenticated-orcid":false,"given":"Daniyar Zh.","family":"Yestay","sequence":"additional","affiliation":[{"name":"National Scientific Center of Traumatology and Orthopedics named after Academician N.D. Batpenov, Astana, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"30777","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"5343","DOI":"10.3390\/polym14245343","article-title":"Regeneration of Osteochondral Defects by Combined Delivery of Synovium-Derived Mesenchymal Stem Cells, TGF-\u03b21 and BMP-4 in Heparin-Conjugated Fibrin Hydrogel","volume":"14","author":"M. Sarsenova","year":"2022","journal-title":"Polymers"},{"issue":"11","key":"ref2","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1007\/s00586-007-0376-0","article-title":"CT-based classification of long spinal allograft fusion","volume":"16","author":"G. H., et al. 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Veronesi","year":"2022","journal-title":"J Clin Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"100392","DOI":"10.1016\/j.wnsx.2024.100392","article-title":"A comparison of transforaminal lumbar interbody fusion (TLIF) cage material on fusion rates: A systematic review and network meta-analysis","volume":"23","author":"S. Pairojboriboon","year":"2024","journal-title":"World Neurosurg X"},{"issue":"7","key":"ref15","doi-asserted-by":"publisher","first-page":"3638","DOI":"10.3390\/ijms22073638","article-title":"Understanding the Future Prospects of Synergizing Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgery with Ceramics and Regenerative Cellular Therapies","volume":"22","author":"W. C. 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Zuk","year":"2001","journal-title":"Tissue Eng"}],"container-title":["Orthopedic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/orthopedicreviews.openmedicalpublishing.org\/article\/159611-osteointegration-and-fusion-after-tlif-trabecular-titanium-cage-with-svf-hydrogel-compared-with-peek-cage","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:45:38Z","timestamp":1793321138000},"score":1,"resource":{"primary":{"URL":"https:\/\/orthopedicreviews.openmedicalpublishing.org\/article\/159611-osteointegration-and-fusion-after-tlif-trabecular-titanium-cage-with-svf-hydrogel-compared-with-peek-cage"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,2]]},"references-count":17,"URL":"https:\/\/doi.org\/10.52965\/001c.159611","relation":{},"ISSN":["2035-8164"],"issn-type":[{"value":"2035-8164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,2]]}}}