{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:31:57Z","timestamp":1793323917306,"version":"4.5.0"},"reference-count":42,"publisher":"Open Medical Publishing","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"\n Introduction<\/jats:title>\n Bone mineral density (BMD) is a key determinant of osteoporotic fracture risk; however, the association between femoral neck BMD and fracture burden across different sex and age groups remains incompletely characterized.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a cross-sectional analysis using NHANES data from 2005\u20132010, 2013\u20132014, and 2017\u2013March 2020. Participants aged \u226550 with femur neck BMD and fracture history were included. Survey-weighted negative binomial regression models and restricted cubic spline analyses were applied to evaluate the association between femoral neck BMD and osteoporotic fracture counts, with stratified analyses by sex and age.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In fully adjusted models, higher femoral neck BMD was associated with lower hip and total osteoporotic fracture counts. Restricted cubic spline analyses demonstrated a nonlinear inverse association between femoral neck BMD and predicted fracture counts. Sex- and age-stratified analyses revealed substantial heterogeneity in these associations, with a stronger inverse relationship observed among older adults, with more consistent inverse patterns among females and age-dependent associations among males.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n Femoral neck BMD is inversely associated with osteoporotic fracture burden in U.S. adults aged \u226550 years, with marked variation by sex and age. These findings highlight the importance of considering demographic heterogeneity when assessing fracture risk using BMD measurements.<\/jats:p>\n <\/jats:sec>","DOI":"10.52965\/001c.161323","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T17:49:26Z","timestamp":1778089766000},"source":"Crossref","is-referenced-by-count":0,"title":["Association Between Femoral Neck Bone Mineral Density and Osteoporotic Fracture Counts in U.S. Adults: A NHANES 2005\u20132020 Analysis"],"prefix":"10.52965","volume":"18","author":[{"given":"Yunfeng","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkou","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"30777","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"issue":"13","key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10133002","article-title":"The Treatment Gap in Osteoporosis","volume":"10","author":"N. 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