{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:31:51Z","timestamp":1793323911984,"version":"4.5.0"},"reference-count":23,"publisher":"Open Medical Publishing","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec id=\"background\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammatory bowel disease (IBD) is increasingly prevalent, and more affected patients are undergoing total knee arthroplasty (TKA). However, the effect of comorbid IBD on short- and long-term postoperative outcomes after TKA remains incompletely defined, particularly for functional and implant-related complications. Existing TKA-specific literature has not clearly established whether this risk persists across multiple postoperative time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective cohort study using the TriNetX Research Network. Adults undergoing primary TKA were identified and stratified by IBD status. Propensity score matching (1:1) balanced demographics and comorbidities, yielding 6134 patients per cohort. Outcomes were assessed at 90 days, 6 months, 2 years, and 5 years and included infectious, thromboembolic, medical, functional, and implant-related complications. Risk ratios with 95% confidence intervals were calculated for each endpoint. Matched cohorts were followed longitudinally across four predefined postoperative intervals after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with IBD demonstrated significantly increased risks of sepsis, pulmonary embolism, acute kidney failure, and periprosthetic joint infection\/deep surgical site infection as early as 90 days. Several risks persisted through 5 years, including thromboembolic events, ischemic stroke, fall risk, abnormal gait, and implant failure. At 5 years, revision TKA rates did not differ significantly between cohorts despite the greater complication burden observed in patients with IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative IBD was associated with sustained postoperative morbidity after TKA, spanning infectious, thromboembolic, functional, and implant-related domains. These findings support enhanced perioperative optimization, closer long-term surveillance, and targeted management strategies for this high-risk population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.52965\/001c.162153","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T16:47:07Z","timestamp":1779468427000},"source":"Crossref","is-referenced-by-count":0,"title":["Inflammatory Bowel Disease Is Associated With Persistent Functional Impairment and Increased Short- and Long-Term Complications Following Total Knee Arthroplasty"],"prefix":"10.52965","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8642-2873","authenticated-orcid":true,"given":"Tarek","family":"Harhash","sequence":"first","affiliation":[{"name":"Wayne State University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Almaat","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alqasim","family":"Elnaggar","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul-Lateef","family":"Shafau","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05gehxw18","id-type":"ROR","asserted-by":"publisher"}],"name":"Detroit Medical Center","department":["Department of Orthopaedic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashar","family":"Jawich","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kareem","family":"Hilo","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Forbes","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyusuf","family":"Elnaggar","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Jaura","sequence":"additional","affiliation":[{"name":"Oakland University William Beaumont School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Saleh","sequence":"additional","affiliation":[{"name":"John D. Dingell Veteran Affairs Medical Center","department":["Department of Orthopaedic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Vaidya","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05gehxw18","id-type":"ROR","asserted-by":"publisher"}],"name":"Detroit Medical Center","department":["Department of Orthopaedic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Darwiche","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05gehxw18","id-type":"ROR","asserted-by":"publisher"}],"name":"Detroit Medical Center","department":["Department of Orthopaedic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"30777","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"publisher","first-page":"160","DOI":"10.2106\/JBJS.20.01585","article-title":"Inflammatory Bowel Diseases Increase the Risk of Periprosthetic Joint Infection","volume":"104","author":"E. 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