{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:31:53Z","timestamp":1793323913159,"version":"4.5.0"},"reference-count":34,"publisher":"Open Medical Publishing","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec id=\"background\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Charcot arthropathy is an ankle injury complication most commonly seen in patients with diabetes. This study aimed to assess Charcot arthropathy prevalence and its associated risk factors among patients with diabetes with ankle injuries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected from the medical records of patients with diabetes with ankle injuries managed at King Abdulaziz Medical City, Riyadh, from April 2015 to April 2020. Recorded data included baseline demographic and clinical characteristics, management approaches, and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 314 patients with diabetes with ankle injuries were included. Most patients were female (n = 192, 61.1%), with an average age of 55.67 years old. The mean body mass index was 32.91 kg\/m2. The prevalence of Charcot arthropathy was 4.1%. HbA1C levels (odds ratio = 1.75, p = 0.023) and co-existing injury complications (odds ratio = 105.408, p = 0.001) were found to be significant predictors of Charcot arthropathy. The mean time for developing Charcot after an ankle injury was 10.62 months. Of the 317 injured ankles, most were managed non-operatively (n = 257, 81.1%), while only 60 (18.9) were managed operatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"conclusion\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High HbA1c levels and co-existing injuries were significant predictors of Charcot arthropathy and showed strong associations with its development in patients with diabetes with ankle injuries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.52965\/001c.164464","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T20:23:24Z","timestamp":1783715004000},"source":"Crossref","is-referenced-by-count":0,"title":["Rate of Developing Charcot Arthropathy Following Ankle Injuries in Patients with Diabetes: A Two-Year Follow-up"],"prefix":"10.52965","volume":"18","author":[{"given":"Faisal A.","family":"Alzahrani","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Ministry of the National Guard \u2013 Health Affairs, Riyadh, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"},{"name":"King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali S.","family":"Alshehri","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Ministry of the National Guard \u2013 Health Affairs, Riyadh, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada S.","family":"Alhamed","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Ministry of the National Guard \u2013 Health Affairs, Riyadh, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid H.","family":"Alhadlaq","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Ministry of the National Guard \u2013 Health Affairs, Riyadh, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz Y.","family":"Almahbub","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"},{"name":"Department of Emergency Medicine, Ministry of the National Guard \u2013 Health Affairs, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled A.","family":"Alhabdan","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"},{"name":"Department of Emergency Medicine, Ministry of the National Guard \u2013 Health Affairs, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fai A.","family":"Alhoshan","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Ministry of the National Guard \u2013 Health Affairs, Riyadh, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan S.","family":"Alhoshan","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"},{"name":"King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8287-9064","authenticated-orcid":true,"given":"Ziad A.","family":"Aljaafri","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Ministry of the National Guard \u2013 Health Affairs, Riyadh, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"},{"name":"King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"30777","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1001\/archsurg.1950.01250010980011","article-title":"Fractures of the ankle. II. Combined experimental-surgical and experimental-roentgenologic investigations","volume":"60","author":"N. Lauge-Hansen","year":"1950","journal-title":"Arch Surg (1920)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/S0140-6736(99)90012-0","article-title":"Progress in care of the diabetic foot","volume":"354","author":"M. E. Edmonds","year":"1999","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/00003086-199311000-00009","article-title":"A short history of neuropathic arthropathy","author":"R. Gupta","year":"1993","journal-title":"Clinical Orthopaedics and Related Research"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1001\/archsurg.1955.01270100039007","article-title":"Diabetic neuropathic arthropathy of feet; summary report of seventeen cases","volume":"70","author":"D. S. Miller","year":"1955","journal-title":"AMA Archives of Surgery"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3402\/dfa.v3i0.12236","article-title":"The pathogenesis of Charcot neuroarthropathy: current concepts","volume":"3","author":"S. A. M. Larson","year":"2012","journal-title":"Diabetic Foot Ankle"},{"key":"ref6","series-title":"Levin and O'Neal's the diabetic foot","first-page":"257","article-title":"The Charcot foot (Pied de Charcot)","author":"L. Sanders","year":"2007","edition":"7"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s00125-002-0885-7","article-title":"Charcot neuroarthropathy in diabetes mellitus","volume":"45","author":"S. M. Rajbhandari","year":"2002","journal-title":"Diabetologia"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-19-00545","article-title":"Effects of diabetes mellitus on functional outcomes and complications after torsional ankle fracture","author":"T. 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Wire","year":"2022"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"107","DOI":"10.4103\/ijem.IJEM_257_17","article-title":"Prevalence of charcot arthropathy in Type 2 diabetes patients aged over 50 years with severe peripheral neuropathy: A retrospective study in a Tertiary Care South Indian Hospital","volume":"22","author":"D. Salini","year":"2018","journal-title":"Indian J Endocr Metab"},{"issue":"10","key":"ref13","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1111\/dme.13679","article-title":"Prevalence of active charcot disease in the East Midlands of England","volume":"35","author":"L. Metcalf","year":"2018","journal-title":"Diabet Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1302\/0301-620X.80B4.0800689","article-title":"Ankle fractures in diabetics: complications of surgical management","volume":"80","author":"R. G. McCormack","year":"1998","journal-title":"J Bone Joint Surg Br"},{"issue":"3","key":"ref15","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1177\/1071100716678796","article-title":"Nonoperative Versus Operative Treatment of Displaced Ankle Fractures in Diabetics","volume":"38","author":"A. J. Lovy","year":"2017","journal-title":"Foot Ankle Int"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.fcl.2006.06.013","article-title":"Ankle fractures in diabetics","volume":"11","author":"V. R. Prisk","year":"2006","journal-title":"Foot Ankle Clin"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/os.12047","article-title":"Effect of the blood HbA1c level on surgical treatment outcomes of diabetics with ankle fractures","volume":"5","author":"J. Liu","year":"2013","journal-title":"Orthop Surg"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"832","DOI":"10.2106\/JBJS.L.01302","article-title":"Neuropathy and poorly controlled diabetes increase the rate of surgical site infection after foot and ankle surgery","volume":"96","author":"D. K. Wukich","year":"2014","journal-title":"J Bone Joint Surg Am"},{"key":"ref19","first-page":"821","article-title":"Management of diabetic neuropathic ankle arthropathy by arthrodesis using an Ilizarov frame","volume":"76","author":"A. H. Yousry","year":"2010","journal-title":"Acta Orthop. Belg."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"736","DOI":"10.2519\/jospt.1999.29.12.736","article-title":"Recognition and management of acute neuropathic (Charcot) arthropathies of the foot and ankle","volume":"29","author":"D. R. Sinacore","year":"1999","journal-title":"J Orthop Sports Phys Ther"},{"issue":"1","key":"ref21","doi-asserted-by":"publisher","first-page":"98","DOI":"10.2337\/dc09-1497","article-title":"Lower-extremity amputation risk after charcot arthropathy and diabetic foot ulcer","volume":"33","author":"M. W. Sohn","year":"2010","journal-title":"Diabetes Care"},{"issue":"11","key":"ref22","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1177\/17504589211006018","article-title":"Current concepts of the perioperative management of closed ankle fractures","volume":"32","author":"X. Chen","year":"2022","journal-title":"J Perioper Pract"},{"issue":"4","key":"ref23","doi-asserted-by":"publisher","first-page":"198","DOI":"10.11622\/smedj.2016074","article-title":"Risk factors of diabetic foot Charcot arthropathy: a case-control study at a Malaysian tertiary care centre","volume":"57","author":"A. A. Fauzi","year":"2016","journal-title":"Singapore Med J"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"796","DOI":"10.2337\/diacare.23.6.796","article-title":"Long-term follow up in diabetic Charcot feet with spontaneous onset","volume":"23","author":"J. Fabrin","year":"2000","journal-title":"Diabetes Care"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.fcl.2006.06.013","article-title":"Ankle fractures in diabetics","volume":"11","author":"V. R. Prisk","year":"2006","journal-title":"Foot Ankle Clin"},{"issue":"8","key":"ref26","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1302\/2058-5241.5.200025","article-title":"Ankle fractures in diabetic patients","volume":"5","author":"N. Gougoulias","year":"2020","journal-title":"EFORT Open Rev"},{"issue":"5","key":"ref27","doi-asserted-by":"publisher","first-page":"20","DOI":"10.7547\/20-246","article-title":"Incidence of Complications and Risk Factors for Nonunion After Ankle Fracture in Diabetes Mellitus","volume":"112","author":"L. A. Lavery","year":"2022","journal-title":"Journal of the American Podiatric Medical Association"},{"issue":"3","key":"ref28","article-title":"Prevalence and Risk Factors of Charcot Foot in Patients with Diabetic Neuropathy","volume":"17","author":"E. Elsayed","year":"2020","journal-title":"Bioscience Research"},{"key":"ref29","article-title":"Sprained ankle - orthoinfo - Aaos","journal-title":"OrthoInfo"},{"issue":"12","key":"ref30","doi-asserted-by":"publisher","first-page":"718","DOI":"10.2519\/jospt.1999.29.12.718","article-title":"Foot and ankle sensory neuropathy, proprioception, and postural stability","volume":"29","author":"R. 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Daly","year":"1987","journal-title":"Acta Orthop Scand"},{"issue":"1","key":"ref34","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3109\/17453679809002355","article-title":"Adult ankle fractures--an increasing problem?","volume":"69","author":"C. M. 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