{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:02:08Z","timestamp":1790362928083,"version":"4.1.0"},"reference-count":19,"publisher":"Open Medical Publishing","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"\n Background<\/jats:title>\n Monitored anesthesia care (MAC) sedation for mechanical thrombectomy in stroke patients is considered safe. The association of MAC sedation with respiratory complications is not well studied.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate adverse events among patients who receive MAC sedation for treatment of acute stroke with thrombectomy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A retrospective review of adverse events at a single institution between 2020 and 2024 was performed. Univariate and multivariable logistic regression identified clinical covariates associated with the likelihood of adverse outcomes.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among 348 patients treated for stroke with MAC, 310 had no adverse events. Univariate analysis showed patients aged 60-69 years were 3.23 times more likely to have an adverse event than patients <60 years old and >8 times more likely to develop acute respiratory failure. Multivariable analysis indicated smokers were 2.4 times more likely to have an adverse event (odds ratio [OR], 2.41; 95% CI, 1.01\u20135.72; p = 0.046). Patients aged 60\u201369 were >3 times as likely to require prolonged ventilation (OR, 3.75; 95% CI, 1.12\u201312.6; p = 0.03). Patients with comorbidities were also >3 times as likely to require prolonged ventilation (OR, 3.45; 95% CI, 1.49\u20137.95; p = 0.004). Age, sex, race, body mass index, stroke location, and stroke history were not associated with adverse events, ventilator use, or acute respiratory failure.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n MAC is a safe method for stroke patients undergoing thrombectomy. Smoking, age 60\u201369 years, and some comorbidities increased odds of respiratory adverse events, underscoring the importance of preoperative risk stratification.<\/jats:p>\n <\/jats:sec>","DOI":"10.52965\/001c.168224","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:46:34Z","timestamp":1789580794000},"source":"Crossref","is-referenced-by-count":0,"title":["Adverse events with monitored anesthesia care sedation in patients with stroke receiving mechanical thrombectomy"],"prefix":"10.52965","volume":"18","author":[{"given":"Blaze T.","family":"Borowski","sequence":"first","affiliation":[{"name":"Creighton University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang","family":"Hyoun Hong","sequence":"additional","affiliation":[{"name":"Creighton University School of Medicine, Mayo Clinic Arizona","department":["Department of Anesthesiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Hovancsek","sequence":"additional","affiliation":[{"name":"Creighton University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malika","family":"Bhargava","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01fwrsq33","id-type":"ROR","asserted-by":"publisher"}],"name":"Barrow Neurological Institute","department":["Neurosurgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kang","sequence":"additional","affiliation":[{"name":"Creighton University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarang S.","family":"Koushik","sequence":"additional","affiliation":[{"name":"Creighton University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Viswanath","sequence":"additional","affiliation":[{"name":"Creighton University School of Medicine","department":["Anesthesiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian G.","family":"Wilhelmi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01fwrsq33","id-type":"ROR","asserted-by":"publisher"}],"name":"Barrow Neurological Institute","department":["Anesthesiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"30777","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"publisher","first-page":"e02161","DOI":"10.1002\/brb3.2161","article-title":"Conscious sedation compared to general anesthesia for intracranial mechanical thrombectomy: A meta-analysis","volume":"11","author":"H. 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