{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:17:54Z","timestamp":1792603074611,"version":"4.5.0"},"reference-count":122,"publisher":"Journal of Biological Methods","issue":"2","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HPR"],"abstract":"<jats:p>Schizophrenia is a debilitating psychotic disorder characterized by positive symptoms such as delusions, hallucinations, and disorganized thoughts, and negative symptoms like lack of effect or motivation. Bipolar 1 disorder (B1D) is a psychiatric illness characterized by recurrent manic episodes in alternation with depressive episodes and interspersed periods of euthymia, ultimately resulting in psychological distress and impairment of daily functioning. Effective treatments are needed for both schizophrenia and B1D to reach the treatment goals of reducing the debilitating symptomology, improving social functioning and quality of life, and increasing the chances of recovery and more favorable long-term outcomes. To date, olanzapine is one of the most efficacious atypical antipsychotics (AAPs) for the treatment of both schizophrenia and B1D and is associated with fewer extrapyramidal effects compared to other treatments. However, compared to other AAPs, olanzapine is associated with a greater chance of metabolic syndrome, limiting its clinical use and affecting treatment compliance. Samidorphan mitigates the weight gain side effects of olanzapine by antagonizing &amp;mu;-, &amp;kappa;-, and &amp;delta;-opioid receptors. The use of combination drugs to treat psychiatric conditions is an emerging field with the goal of increasing therapeutic efficacy and decreasing undesirable side effects. Clinical trials have demonstrated combination on olanzapine and samidorphan (OLZ\/SAM) treatment resulted in significantly less weight gain than olanzapine monotherapy. Clinical trial patients reported improvements in symptoms of psychosis, reduced weight gain, and overall satisfaction with their treatment. OLZ\/SAM has been as shown to be a safe and effective pharmaceutical option for the clinical management of schizophrenia and B1D.<\/jats:p>","DOI":"10.52965\/001c.34224","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T07:40:17Z","timestamp":1650872417000},"page":"1","source":"Crossref","is-referenced-by-count":4,"title":["Combination Olanzapine and Samidorphan for the Management of \u00a0Schizophrenia and Bipolar 1 Disorder in Adults: A Narrative Review"],"prefix":"10.14440","volume":"10","author":[{"given":"Hannah","family":"W. Haddad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Boardman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rama","family":"Mouhaffel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"M. Kaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"D. Kaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5574","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"ref1","unstructured":"100.Prescribing information for LYBALVI. Accessed September 7, 2021. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2021\/213378s000lbl.pdf"},{"key":"ref2","article-title":"Olanzapine","author":"K Thomas","year":"2021"},{"issue":"3","key":"ref3","doi-asserted-by":"publisher","first-page":"e2693","DOI":"10.1002\/hup.2693","article-title":"Effects of olanzapine during cognitive and emotional processing in schizophrenia: A review of functional magnetic resonance imaging findings","volume":"34","author":"Lorenzo Del Fabro","year":"2019","journal-title":"Human Psychopharmacology: Clinical and Experimental","ISSN":"https:\/\/id.crossref.org\/issn\/0885-6222","issn-type":"print"},{"issue":"7","key":"ref4","doi-asserted-by":"publisher","first-page":"e5139","DOI":"10.7759\/cureus.5139","article-title":"A Review of Samidorphan: A Novel Opioid Antagonist","volume":"11","author":"Amna Mohyud Din Chaudhary","year":"2019","journal-title":"Cureus","ISSN":"https:\/\/id.crossref.org\/issn\/2168-8184","issn-type":"print"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"173157","DOI":"10.1016\/j.pbb.2021.173157","article-title":"Samidorphan, an opioid receptor antagonist, attenuates drug-induced increases in extracellular dopamine concentrations and drug self-administration in male Wistar rats","volume":"204","author":"Jacobi I. Cunningham","year":"2021","journal-title":"Pharmacology Biochemistry and Behavior","ISSN":"https:\/\/id.crossref.org\/issn\/0091-3057","issn-type":"print"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.neuropharm.2018.11.015","article-title":"Opioid system modulators buprenorphine and samidorphan alter behavior and extracellular neurotransmitter concentrations in the Wistar Kyoto rat","volume":"146","author":"Karen L. Smith","year":"2019","journal-title":"Neuropharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3908","issn-type":"print"},{"issue":"11","key":"ref7","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1016\/j.clinthera.2018.09.002","article-title":"Pharmacokinetics and Short-term Safety of ALKS 3831, a Fixed-dose Combination of Olanzapine and Samidorphan, in Adult Subjects with Schizophrenia","volume":"40","author":"Lei Sun","year":"2018","journal-title":"Clinical Therapeutics","ISSN":"https:\/\/id.crossref.org\/issn\/0149-2918","issn-type":"print"},{"issue":"2","key":"ref8","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/psp4.12488","article-title":"Physiologically-Based Pharmacokinetic Modeling for Predicting Drug Interactions of a Combination of Olanzapine and Samidorphan","volume":"9","author":"Lei Sun","year":"2020","journal-title":"CPT: Pharmacometrics &amp; Systems Pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/2163-8306","issn-type":"print"},{"issue":"4","key":"ref9","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1345\/aph.1m398","article-title":"Impact of tobacco smoking cessation on stable clozapine or olanzapine treatment","volume":"44","author":"Erin J Lowe","year":"2010","journal-title":"Annals of Pharmacotherapy","ISSN":"https:\/\/id.crossref.org\/issn\/1060-0280","issn-type":"print"},{"issue":"11","key":"ref10","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1002\/jcph.1911","article-title":"Population Pharmacokinetics of Olanzapine and Samidorphan When Administered in Combination in Healthy Subjects and Patients With Schizophrenia","volume":"61","author":"Lei Sun","year":"2021","journal-title":"The Journal of Clinical Pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0091-2700","issn-type":"print"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"481","DOI":"10.2147\/ceor.s259338","article-title":"The Economic Burden of Bipolar Disorder in the United States: A Systematic Literature Review","volume":"12","author":"Leona Bessonova","year":"2020","journal-title":"ClinicoEconomics and Outcomes Research","ISSN":"https:\/\/id.crossref.org\/issn\/1178-6981","issn-type":"print"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.2147\/dddt.s205000","article-title":"Effect of hepatic and renal impairment on the pharmacokinetics of olanzapine and samidorphan given in combination as a bilayer tablet","volume":"13","author":"Lei Sun","year":"2019","journal-title":"Drug Design, Development and Therapy","ISSN":"https:\/\/id.crossref.org\/issn\/1177-8881","issn-type":"print"},{"issue":"2","key":"ref13","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1017\/s1092852920002771","article-title":"A Combination of Olanzapine and Samidorphan in Adults with Schizophrenia and Bipolar I Disorder: Overview of Clinical Data","volume":"26","author":"Leslie Citrome","year":"2021","journal-title":"CNS Spectrums","ISSN":"https:\/\/id.crossref.org\/issn\/1092-8529","issn-type":"print"},{"issue":"2","key":"ref14","doi-asserted-by":"publisher","first-page":"19m12769","DOI":"10.4088\/jcp.19m12769","article-title":"Efficacy and Safety of a Combination of Olanzapine and Samidorphan in Adult Patients With an Acute Exacerbation of Schizophrenia: Outcomes From the Randomized, Phase 3 ENLIGHTEN-1 Study","volume":"81","author":"Steven G. Potkin","year":"2020","journal-title":"The Journal of Clinical Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/1555-2101","issn-type":"print"},{"issue":"2","key":"ref15","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1017\/s1092852920002503","article-title":"Qualitative Clinical Trial Exit Interviews Evaluating Treatment Benefit, Burden, and Satisfaction in Patients with Schizophrenia","volume":"26","author":"Adam Simmons","year":"2021","journal-title":"CNS Spectrums","ISSN":"https:\/\/id.crossref.org\/issn\/1092-8529","issn-type":"print"},{"issue":"4","key":"ref16","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1017\/s1092852920001376","article-title":"Long-term safety and durability of effect with a combination of olanzapine and samidorphan in patients with schizophrenia: results from a 1-year open-label extension study","volume":"26","author":"Sergey Yagoda","year":"2021","journal-title":"CNS Spectrums","ISSN":"https:\/\/id.crossref.org\/issn\/1092-8529","issn-type":"print"},{"issue":"1","key":"ref17","doi-asserted-by":"publisher","first-page":"7583","DOI":"10.1038\/s41598-021-87285-w","article-title":"A meta-analysis comparing short-term weight and cardiometabolic changes between olanzapine\/samidorphan and olanzapine","volume":"11","author":"Manit Srisurapanont","year":"2021","journal-title":"Scientific Reports","ISSN":"https:\/\/id.crossref.org\/issn\/2045-2322","issn-type":"print"},{"issue":"12","key":"ref18","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1176\/appi.ajp.2020.19121279","article-title":"Effects of Olanzapine Combined With Samidorphan on Weight Gain in Schizophrenia: A 24-Week Phase 3 Study","volume":"177","author":"Christoph U. Correll","year":"2020","journal-title":"American Journal of Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0002-953X","issn-type":"print"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.schres.2021.04.009","article-title":"A phase 3, multicenter study to assess the 1-year safety and tolerability of a combination of olanzapine and samidorphan in patients with schizophrenia: results from the ENLIGHTEN-2 long-term extension","volume":"232","author":"Ren\u00e9 S. Kahn","year":"2021","journal-title":"Schizophrenia Research","ISSN":"https:\/\/id.crossref.org\/issn\/0920-9964","issn-type":"print"},{"issue":"2","key":"ref20","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1017\/s1092852920002485","article-title":"Phase 3 Safety and Tolerability Results of the Combination Olanzapine and Samidorphan in Patients with Schizophrenia: The 1 Year ENLIGHTEN-2-Extension","volume":"26","author":"Rene Kahn","year":"2021","journal-title":"CNS Spectrums","ISSN":"https:\/\/id.crossref.org\/issn\/1092-8529","issn-type":"print"},{"issue":"4","key":"ref21","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/cpdd.601","article-title":"Bioequivalence of Olanzapine Given in Combination With Samidorphan as a Bilayer Tablet (ALKS 3831) Compared With Olanzapine-Alone Tablets: Results From a Randomized, Crossover Relative Bioavailability Study","volume":"8","author":"Lei Sun","year":"2019","journal-title":"Clinical Pharmacology in Drug Development","ISSN":"https:\/\/id.crossref.org\/issn\/2160-763X","issn-type":"print"},{"issue":"1","key":"ref22","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1080\/03007995.2020.1841618","article-title":"The burden of disease in early schizophrenia \u2013 a systematic literature review","volume":"37","author":"Benedicto Crespo-Facorro","year":"2021","journal-title":"Current Medical Research and Opinion","ISSN":"https:\/\/id.crossref.org\/issn\/0300-7995","issn-type":"print"},{"issue":"1","key":"ref23","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s40261-019-00860-y","article-title":"Combination of Olanzapine and Samidorphan Has No Clinically Significant Effect on the Pharmacokinetics of Lithium or Valproate","volume":"40","author":"Lei Sun","year":"2020","journal-title":"Clinical Drug Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/1173-2563","issn-type":"print"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"109881","DOI":"10.1016\/j.pnpbp.2020.109881","article-title":"Combination of olanzapine and samidorphan has no clinically relevant effects on ECG parameters, including the QTc interval: results from a phase 1 QT\/QTc study","volume":"100","author":"Lei Sun","year":"2020","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0278-5846","issn-type":"print"},{"issue":"2","key":"ref25","doi-asserted-by":"publisher","first-page":"19m12786","DOI":"10.4088\/jcp.19m12786","article-title":"Olanzapine Plus Samidorphan (ALKS 3831) in Schizophrenia and Comorbid Alcohol Use Disorder: A Phase 2, Randomized Clinical Trial","volume":"81","author":"Mary F. Brunette","year":"2020","journal-title":"The Journal of Clinical Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/1555-2101","issn-type":"print"},{"issue":"12","key":"ref26","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1007\/s40265-021-01568-0","article-title":"Olanzapine\/Samidorphan: First Approval","volume":"81","author":"Julia Paik","year":"2021","journal-title":"Drugs","ISSN":"https:\/\/id.crossref.org\/issn\/0012-6667","issn-type":"print"},{"issue":"2","key":"ref27","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1001\/jamapsychiatry.2019.3360","article-title":"Schizophrenia\u2014An Overview","volume":"77","author":"Robert A. McCutcheon","year":"2020","journal-title":"JAMA Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/2168-622X","issn-type":"print"},{"issue":"5","key":"ref28","doi-asserted-by":"publisher","first-page":"e141","DOI":"10.1371\/journal.pmed.0020141","article-title":"A systematic review of the prevalence of schizophrenia","volume":"2","author":"Sukanta Saha","year":"2005","journal-title":"PLoS Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1549-1676","issn-type":"print"},{"issue":"6","key":"ref29","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1093\/schbul\/sby058","article-title":"Global Epidemiology and Burden of Schizophrenia: Findings From the Global Burden of Disease Study 2016","volume":"44","author":"Fiona J Charlson","year":"2018","journal-title":"Schizophrenia Bulletin","ISSN":"https:\/\/id.crossref.org\/issn\/0586-7614","issn-type":"print"},{"issue":"3","key":"ref30","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.psc.2007.04.007","article-title":"Epidemiology of Schizophrenia: Review of Findings and Myths","volume":"30","author":"Erick L. Messias","year":"2007","journal-title":"Psychiatric Clinics of North America","ISSN":"https:\/\/id.crossref.org\/issn\/0193-953X","issn-type":"print"},{"issue":"6","key":"ref31","doi-asserted-by":"publisher","first-page":"5075","DOI":"10.1007\/s12035-017-0708-y","article-title":"Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review","volume":"55","author":"B\u0142a\u017cej Misiak","year":"2018","journal-title":"Molecular Neurobiology","ISSN":"https:\/\/id.crossref.org\/issn\/0893-7648","issn-type":"print"},{"issue":"1","key":"ref32","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1002\/(sici)1096-8628(200021)97:1","article-title":"Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics","volume":"97","author":"Alastair G. Cardno","year":"2000","journal-title":"American Journal of Medical Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0148-7299","issn-type":"print"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2016.00083","article-title":"Editorial: Endophenotypes for Schizophrenia and Mood Disorders: Implications from Genetic, Biochemical, Cognitive, Behavioral, and Neuroimaging Studies","volume":"7","author":"B\u0142a\u017cej Misiak","year":"2016","journal-title":"Frontiers in Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/1664-0640","issn-type":"print"},{"key":"ref34","series-title":"StatPearls","article-title":"Schizophrenia","author":"M. Hany","year":"2021"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.comppsych.2017.09.009","article-title":"Risk factors in early and late onset schizophrenia","volume":"80","author":"Laura Chen","year":"2018","journal-title":"Comprehensive Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0010-440X","issn-type":"print"},{"issue":"10","key":"ref36","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s11920-019-1091-3","article-title":"Non-Genetic Factors in Schizophrenia","volume":"21","author":"Simona A. Stilo","year":"2019","journal-title":"Current Psychiatry Reports","ISSN":"https:\/\/id.crossref.org\/issn\/1523-3812","issn-type":"print"},{"issue":"1","key":"ref37","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1146\/annurev-clinpsy-032813-153657","article-title":"Excess early mortality in schizophrenia","volume":"10","author":"Thomas Munk Laursen","year":"2014","journal-title":"Annual Review of Clinical Psychology","ISSN":"https:\/\/id.crossref.org\/issn\/1548-5943","issn-type":"print"},{"issue":"7510","key":"ref38","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nature13595","article-title":"Biological insights from 108 schizophrenia-associated genetic loci","volume":"511","author":"Schizophrenia Working Group of the Psychiatric Genomics Consortium","year":"2014","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jpsychires.2013.10.018","article-title":"Catechol-O-methyltransferase (COMT) genotype moderates the effects of childhood trauma on cognition and symptoms in schizophrenia","volume":"49","author":"Melissa J. Green","year":"2014","journal-title":"Journal of Psychiatric Research","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3956","issn-type":"print"},{"issue":"6","key":"ref40","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1093\/schbul\/sbn117","article-title":"Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions","volume":"34","author":"J. van Os","year":"2008","journal-title":"Schizophrenia Bulletin","ISSN":"https:\/\/id.crossref.org\/issn\/0586-7614","issn-type":"print"},{"issue":"6","key":"ref41","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1093\/schbul\/sbr134","article-title":"Neuroanatomical Maps of Psychosis Onset: Voxel-wise Meta-Analysis of Antipsychotic-Naive VBM Studies","volume":"38","author":"P. Fusar-Poli","year":"2012","journal-title":"Schizophrenia Bulletin","ISSN":"https:\/\/id.crossref.org\/issn\/0586-7614","issn-type":"print"},{"issue":"suppl 1","key":"ref42","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1093\/schbul\/sbv174","article-title":"Aberrant Functional Whole-Brain Network Architecture in Patients With Schizophrenia: A Meta-analysis","volume":"42","author":"Joseph Kambeitz","year":"2016","journal-title":"Schizophrenia Bulletin","ISSN":"https:\/\/id.crossref.org\/issn\/0586-7614","issn-type":"print"},{"issue":"11","key":"ref43","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.biopsych.2015.02.017","article-title":"In Search of Multimodal Neuroimaging Biomarkers of Cognitive Deficits in Schizophrenia","volume":"78","author":"Jing Sui","year":"2015","journal-title":"Biological Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3223","issn-type":"print"},{"issue":"9","key":"ref44","first-page":"638","article-title":"Schizophrenia: overview and treatment options","volume":"39","author":"K.R. Patel","year":"2014","journal-title":"P T Peer-Rev J Formul Manag"},{"issue":"1","key":"ref45","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.schres.2013.05.028","article-title":"Definition and description of schizophrenia in the DSM-5","volume":"150","author":"Rajiv Tandon","year":"2013","journal-title":"Schizophrenia Research","ISSN":"https:\/\/id.crossref.org\/issn\/0920-9964","issn-type":"print"},{"issue":"8","key":"ref46","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1038\/mp.2017.249","article-title":"Hippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention","volume":"23","author":"J A Lieberman","year":"2018","journal-title":"Molecular Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/1359-4184","issn-type":"print"},{"issue":"1","key":"ref47","doi-asserted-by":"publisher","first-page":"18008","DOI":"10.1038\/nrdp.2018.8","article-title":"Bipolar disorders","volume":"4","author":"Eduard Vieta","year":"2018","journal-title":"Nature Reviews Disease Primers","ISSN":"https:\/\/id.crossref.org\/issn\/2056-676X","issn-type":"print"},{"issue":"10159","key":"ref48","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/s0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"Spencer L James","year":"2018","journal-title":"The Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.2147\/ndt.s285540","article-title":"The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress","volume":"16","author":"Yann Quid\u00e9","year":"2020","journal-title":"Neuropsychiatric Disease and Treatment","ISSN":"https:\/\/id.crossref.org\/issn\/1178-2021","issn-type":"print"},{"issue":"5","key":"ref50","doi-asserted-by":"publisher","first-page":"389","DOI":"10.2165\/00023210-200822050-00003","article-title":"Burden of bipolar depression: impact of disorder and medications on quality of life","volume":"22","author":"Erin E Michalak","year":"2008","journal-title":"CNS Drugs","ISSN":"https:\/\/id.crossref.org\/issn\/1172-7047","issn-type":"print"},{"issue":"1-3","key":"ref51","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/s0165-0327(01)00432-3","article-title":"The Stanley Foundation Bipolar Treatment Outcome Network. II. Demographics and illness characteristics of the first 261 patients","volume":"67","author":"Trisha Suppes","year":"2001","journal-title":"Journal of Affective Disorders","ISSN":"https:\/\/id.crossref.org\/issn\/0165-0327","issn-type":"print"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.psychres.2016.12.058","article-title":"Influences of patient informed cognitive complaints on activities of daily living in patients with bipolar disorder. An exploratory cross-sectional study","volume":"249","author":"Conny Tr\u00e4ger","year":"2017","journal-title":"Psychiatry Research","ISSN":"https:\/\/id.crossref.org\/issn\/0165-1781","issn-type":"print"},{"issue":"3","key":"ref53","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/acps.12087","article-title":"Employment outcomes in people with bipolar disorder: a systematic review","volume":"128","author":"S. Marwaha","year":"2013","journal-title":"Acta Psychiatrica Scandinavica","ISSN":"https:\/\/id.crossref.org\/issn\/0001-690X","issn-type":"print"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.cpr.2017.11.006","article-title":"Cognitive deficits in bipolar disorders: Implications for emotion","volume":"59","author":"Isabela M.M. Lima","year":"2018","journal-title":"Clinical Psychology Review","ISSN":"https:\/\/id.crossref.org\/issn\/0272-7358","issn-type":"print"},{"issue":"3","key":"ref55","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1001\/archgenpsychiatry.2011.12","article-title":"Prevalence and Correlates of Bipolar Spectrum Disorder in the World Mental Health Survey Initiative","volume":"68","author":"Kathleen R. Merikangas","year":"2011","journal-title":"Archives of General Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0003-990X","issn-type":"print"},{"issue":"18","key":"ref56","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1056\/nejmra1808803","article-title":"Schizophrenia","volume":"381","author":"Stephen R. Marder","year":"2019","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"1","key":"ref57","doi-asserted-by":"publisher","first-page":"41380","DOI":"10.1038\/s41380-021-01091-4","article-title":"A unified model of the pathophysiology of bipolar disorder","volume":"27","author":"Paola Magioncalda","year":"2021","journal-title":"Molecular Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/1359-4184","issn-type":"print"},{"issue":"5","key":"ref58","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.neubiorev.2009.01.004","article-title":"Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide","volume":"33","author":"Jonathan Savitz","year":"2009","journal-title":"Neuroscience & Biobehavioral Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0149-7634","issn-type":"print"},{"issue":"11","key":"ref59","doi-asserted-by":"publisher","first-page":"e946","DOI":"10.1038\/tp.2016.212","article-title":"Neuropathology of mood disorders: do we see the stigmata of inflammation?","volume":"6","author":"N Mechawar","year":"2016","journal-title":"Translational Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/2158-3188","issn-type":"print"},{"issue":"1","key":"ref60","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.bbr.2009.06.009","article-title":"In vivo imaging of synaptic function in the central nervous system: II. Mental and affective disorders","volume":"204","author":"Susanne Nikolaus","year":"2009","journal-title":"Behavioural Brain Research","ISSN":"https:\/\/id.crossref.org\/issn\/0166-4328","issn-type":"print"},{"issue":"10","key":"ref61","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.tics.2011.08.003","article-title":"Large-scale brain networks and psychopathology: a unifying triple network model","volume":"15","author":"Vinod Menon","year":"2011","journal-title":"Trends in Cognitive Sciences","ISSN":"https:\/\/id.crossref.org\/issn\/1364-6613","issn-type":"print"},{"issue":"1","key":"ref62","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41380-020-0814-5","article-title":"All roads lead to the motor cortex: psychomotor mechanisms and their biochemical modulation in psychiatric disorders","volume":"26","author":"Georg Northoff","year":"2021","journal-title":"Molecular Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/1359-4184","issn-type":"print"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-00982-2","article-title":"Tracing the psychopathology of bipolar disorder to the functional architecture of intrinsic brain activity and its neurotransmitter modulation: a three-dimensional model","author":"Matteo Martino","year":"2021","journal-title":"Molecular Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/1359-4184","issn-type":"print"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.jpsychires.2017.03.018","article-title":"A systematic review of evidence for the role of inflammatory biomarkers in bipolar patients","volume":"92","author":"Pavani Sayana","year":"2017","journal-title":"Journal of Psychiatric Research","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3956","issn-type":"print"},{"issue":"12","key":"ref65","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/s2215-0366(16)30370-4","article-title":"C-reactive protein concentrations across the mood spectrum in bipolar disorder: a systematic review and meta-analysis","volume":"3","author":"Brisa S Fernandes","year":"2016","journal-title":"The Lancet Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/2215-0366","issn-type":"print"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.neuroscience.2015.05.018","article-title":"The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders","volume":"300","author":"G.Z. R\u00e9us","year":"2015","journal-title":"Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0306-4522","issn-type":"print"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"357","DOI":"10.2147\/ndt.s96649","article-title":"Global economic burden of schizophrenia: a systematic review","volume":"12","author":"Nathorn Chaiyakunapruk","year":"2016","journal-title":"Neuropsychiatric Disease and Treatment","ISSN":"https:\/\/id.crossref.org\/issn\/1178-2021","issn-type":"print"},{"issue":"1","key":"ref68","doi-asserted-by":"publisher","first-page":"pyu021","DOI":"10.1093\/ijnp\/pyu021","article-title":"Monocyte and lymphocyte activation in bipolar disorder: a new piece in the puzzle of immune dysfunction in mood disorders","volume":"18","author":"I. G. Barbosa","year":"2014","journal-title":"International Journal of Neuropsychopharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/1461-1457","issn-type":"print"},{"issue":"2","key":"ref69","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/s0006-3223(02)01452-x","article-title":"High numbers of circulating activated T cells and raised levels of serum IL-2 receptor in bipolar disorder","volume":"53","author":"M.Nadine Breunis","year":"2003","journal-title":"Biological Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3223","issn-type":"print"},{"issue":"8","key":"ref70","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/s0006-3223(98)00159-0","article-title":"Activation of indices of cell-mediated immunity in bipolar mania","volume":"45","author":"Shang-Ying Tsai","year":"1999","journal-title":"Biological Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3223","issn-type":"print"},{"issue":"5","key":"ref71","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.psyneuen.2012.08.005","article-title":"Reduced regulatory T cells are associated with higher levels of Th1\/TH17 cytokines and activated MAPK in type 1 bipolar disorder","volume":"38","author":"Carine Hartmann do Prado","year":"2013","journal-title":"Psychoneuroendocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0306-4530","issn-type":"print"},{"issue":"7","key":"ref72","doi-asserted-by":"publisher","first-page":"e406","DOI":"10.1038\/tp.2014.46","article-title":"Increased M1\/decreased M2 signature and signs of Th1\/Th2 shift in chronic patients with bipolar disorder, but not in those with schizophrenia","volume":"4","author":"P Brambilla","year":"2014","journal-title":"Translational Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/2158-3188","issn-type":"print"},{"issue":"4","key":"ref73","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1177\/0004867416644508","article-title":"White blood cell count correlates with mood symptom severity and specific mood symptoms in bipolar disorder","volume":"51","author":"Ole K\u00f6hler","year":"2017","journal-title":"Australian & New Zealand Journal of Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0004-8674","issn-type":"print"},{"issue":"1","key":"ref74","doi-asserted-by":"publisher","first-page":"40530","DOI":"10.1038\/srep40530","article-title":"Circulating T lymphocyte subsets, cytokines, and immune checkpoint inhibitors in patients with bipolar II or major depression: a preliminary study","volume":"7","author":"Wei Wu","year":"2017","journal-title":"Scientific Reports","ISSN":"https:\/\/id.crossref.org\/issn\/2045-2322","issn-type":"print"},{"issue":"8","key":"ref75","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1111\/bdi.12570","article-title":"Levels of interleukin-6 and high-sensitivity C-reactive protein reflecting mania severity in bipolar disorder","volume":"19","author":"Shang-Ying Tsai","year":"2017","journal-title":"Bipolar Disorders","ISSN":"https:\/\/id.crossref.org\/issn\/1398-5647","issn-type":"print"},{"issue":"9","key":"ref76","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.biopsych.2009.05.024","article-title":"A systematic review of diffusion tensor imaging studies in affective disorders","volume":"66","author":"Claire E. Sexton","year":"2009","journal-title":"Biological Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3223","issn-type":"print"},{"issue":"8","key":"ref77","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1016\/j.pnpbp.2011.05.009","article-title":"A meta-analysis of whole-brain diffusion tensor imaging studies in bipolar disorder","volume":"35","author":"Fran\u00e7ois-Eric Vederine","year":"2011","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0278-5846","issn-type":"print"},{"issue":"1","key":"ref78","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1056\/nejmra1906193","article-title":"Bipolar Disorder","volume":"383","author":"Andre F. Carvalho","year":"2020","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"2","key":"ref79","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jad.2013.05.034","article-title":"Systematic review and voxel-based meta-analysis of diffusion tensor imaging studies in bipolar disorder","volume":"150","author":"Gareth Nortje","year":"2013","journal-title":"Journal of Affective Disorders","ISSN":"https:\/\/id.crossref.org\/issn\/0165-0327","issn-type":"print"},{"issue":"4","key":"ref80","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.biopsych.2015.03.004","article-title":"Voxel-Based Meta-Analytical Evidence of Structural Disconnectivity in Major Depression and Bipolar Disorder","volume":"79","author":"Toby Wise","year":"2016","journal-title":"Biological Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3223","issn-type":"print"},{"issue":"5","key":"ref81","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1007\/s00702-010-0368-9","article-title":"White matter abnormalities in bipolar disorder: insights from diffusion tensor imaging studies","volume":"117","author":"Serene Heng","year":"2010","journal-title":"Journal of Neural Transmission","ISSN":"https:\/\/id.crossref.org\/issn\/0300-9564","issn-type":"print"},{"issue":"13","key":"ref82","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1038\/s41386-019-0485-6","article-title":"Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals","volume":"44","author":"Pauline Favre","year":"2019","journal-title":"Neuropsychopharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0893-133X","issn-type":"print"},{"issue":"3","key":"ref83","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"B. T. Thomas Yeo","year":"2011","journal-title":"Journal of Neurophysiology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3077","issn-type":"print"},{"issue":"8","key":"ref84","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1017\/s1092852900013754","article-title":"The subgenual anterior cingulate cortex in mood disorders","volume":"13","author":"Wayne C. Drevets","year":"2008","journal-title":"CNS Spectrums","ISSN":"https:\/\/id.crossref.org\/issn\/1092-8529","issn-type":"print"},{"issue":"1","key":"ref85","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/sj.mp.4000589","article-title":"The role of stress in the pathophysiology of the dopaminergic system","volume":"5","author":"L Pani","year":"2000","journal-title":"Molecular Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/1359-4184","issn-type":"print"},{"issue":"6","key":"ref86","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1016\/j.neubiorev.2008.04.006","article-title":"Corticosteroid-serotonin interactions in the neurobiological mechanisms of stress-related disorders","volume":"32","author":"Laurence Lanfumey","year":"2008","journal-title":"Neuroscience & Biobehavioral Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0149-7634","issn-type":"print"},{"issue":"17","key":"ref87","doi-asserted-by":"publisher","first-page":"4824","DOI":"10.1073\/pnas.1517558113","article-title":"Contrasting variability patterns in the default mode and sensorimotor networks balance in bipolar depression and mania","volume":"113","author":"Matteo Martino","year":"2016","journal-title":"Proceedings of the National Academy of Sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"1","key":"ref88","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/s41380-019-0406-4","article-title":"Opposite effects of dopamine and serotonin on resting-state networks: review and implications for psychiatric disorders","volume":"25","author":"Benedetta Conio","year":"2020","journal-title":"Molecular Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/1359-4184","issn-type":"print"},{"issue":"1","key":"ref89","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/jopy.12461","article-title":"Identity in bipolar disorder: self-worth and achievement","volume":"88","author":"Manon L. Ironside","year":"2020","journal-title":"Journal of Personality","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3506","issn-type":"print"},{"issue":"2","key":"ref90","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1080\/13696998.2017.1379412","article-title":"Medication adherence and discontinuation of long-acting injectable versus oral antipsychotics in patients with schizophrenia or bipolar disorder","volume":"21","author":"Mallik Greene","year":"2018","journal-title":"Journal of Medical Economics","ISSN":"https:\/\/id.crossref.org\/issn\/1369-6998","issn-type":"print"},{"issue":"10","key":"ref91","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.3390\/ijms19103105","article-title":"Multi-Target Approach for Drug Discovery against Schizophrenia","volume":"19","author":"Magda Kondej","year":"2018","journal-title":"International Journal of Molecular Sciences","ISSN":"https:\/\/id.crossref.org\/issn\/1422-0067","issn-type":"print"},{"issue":"1","key":"ref92","first-page":"56","article-title":"Exercise as a Treatment for Schizophrenia: A Review","volume":"49","author":"S.J. Girdler","year":"2019","journal-title":"Psychopharmacol Bull"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"104257","DOI":"10.1016\/j.nbd.2018.08.016","article-title":"Treatment resistant schizophrenia: Clinical, biological, and therapeutic perspectives","volume":"131","author":"Frederick C., Jr. Nucifora","year":"2019","journal-title":"Neurobiology of Disease","ISSN":"https:\/\/id.crossref.org\/issn\/0969-9961","issn-type":"print"},{"issue":"8","key":"ref94","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.3390\/molecules23082087","article-title":"Current Concepts and Treatments of Schizophrenia","volume":"23","author":"Piotr St\u0119pnicki","year":"2018","ISSN":"https:\/\/id.crossref.org\/issn\/1420-3049","issn-type":"print"},{"issue":"4","key":"ref95","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1515\/revneuro-2013-0011","article-title":"Does the dopamine hypothesis explain schizophrenia?","volume":"24","author":"Chi-Ieong Lau","year":"2013","journal-title":"Reviews in the Neurosciences","ISSN":"https:\/\/id.crossref.org\/issn\/2191-0200","issn-type":"print"},{"issue":"2","key":"ref96","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/j.1600-0773.1963.tb01730.x","article-title":"Effect of Chlorpromazine or Haloperidol on Formation of 3-Methoxytyramine and Normetanephrine in Mouse Brain","volume":"20","author":"Arvid Carlsson","year":"2009","journal-title":"Acta Pharmacologica et Toxicologica","ISSN":"https:\/\/id.crossref.org\/issn\/0001-6683","issn-type":"print"},{"issue":"5","key":"ref97","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1517\/14656566.6.5.803","article-title":"Risperidone: a review","volume":"6","author":"Hans-J\u00fcrgen M\u00f6ller","year":"2005","journal-title":"Expert Opinion on Pharmacotherapy","ISSN":"https:\/\/id.crossref.org\/issn\/1465-6566","issn-type":"print"},{"issue":"8","key":"ref98","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1038\/sj.npp.1300203","article-title":"Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology","volume":"28","author":"David A Shapiro","year":"2003","journal-title":"Neuropsychopharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0893-133X","issn-type":"print"},{"issue":"2","key":"ref99","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1001\/archgenpsychiatry.2009.193","article-title":"Hippocampal Plasticity in Response to Exercise in Schizophrenia","volume":"67","author":"Frank-Gerald Pajonk","year":"2010","journal-title":"Archives of General Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0003-990X","issn-type":"print"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/978-1-4939-9554-7_4","article-title":"Bipolar Disorder: Its Etiology and How to Model in Rodents","volume":"2011","author":"Nadja Freund","year":"2019","journal-title":"Methods in Molecular Biology","ISSN":"https:\/\/id.crossref.org\/issn\/1064-3745","issn-type":"print"},{"issue":"5","key":"ref101","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1080\/j.1440-1614.1999.06241.x","article-title":"Lithium salts in the treatment of psychotic excitement","volume":"33","author":"John F. J. Cade","year":"1999","journal-title":"Australian and New Zealand Journal of Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0004-8674","issn-type":"print"},{"issue":"9799","key":"ref102","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1016\/s0140-6736(11)60873-8","article-title":"Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis","volume":"378","author":"Andrea Cipriani","year":"2011","journal-title":"The Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"issue":"2","key":"ref103","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s41380-018-0044-2","article-title":"Pharmacological treatment of adult bipolar disorder","volume":"24","author":"Ross J. Baldessarini","year":"2019","journal-title":"Molecular Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/1359-4184","issn-type":"print"},{"issue":"2","key":"ref104","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/npp.2010.192","article-title":"Efficacy of Antimanic Treatments: Meta-analysis of Randomized, Controlled Trials","volume":"36","author":"Ay\u015feg\u00fcl Yildiz","year":"2011","journal-title":"Neuropsychopharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0893-133X","issn-type":"print"},{"issue":"3","key":"ref105","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/j.1399-5618.2010.00812.x","article-title":"Morbidity in 303 first-episode bipolar I disorder patients","volume":"12","author":"Ross J Baldessarini","year":"2010","journal-title":"Bipolar Disorders","ISSN":"https:\/\/id.crossref.org\/issn\/1398-5647","issn-type":"print"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jad.2015.02.011","article-title":"Long-term morbidity in bipolar-I, bipolar-II, and unipolar major depressive disorders","volume":"178","author":"Alberto Forte","year":"2015","journal-title":"Journal of Affective Disorders","ISSN":"https:\/\/id.crossref.org\/issn\/0165-0327","issn-type":"print"},{"issue":"11","key":"ref107","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1176\/appi.ajp.2013.13020185","article-title":"The International Society for Bipolar Disorders (ISBD) Task Force Report on Antidepressant Use in Bipolar Disorders","volume":"170","author":"Isabella Pacchiarotti","year":"2013","journal-title":"American Journal of Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0002-953X","issn-type":"print"},{"issue":"6","key":"ref108","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1177\/0269881116636545","article-title":"Evidence-based guidelines for treating bipolar disorder: revised third edition Recommendations from the British Association for Psychopharmacology","volume":"30","author":"G M Goodwin","year":"2016","journal-title":"Journal of Psychopharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0269-8811","issn-type":"print"},{"issue":"03","key":"ref109","doi-asserted-by":"publisher","first-page":"380","DOI":"10.4088\/jcp.v68n0304","article-title":"Lithium treatment reduces suicide risk in recurrent major depressive disorder","volume":"68","author":"Francesca Guzzetta","year":"2007","journal-title":"The Journal of Clinical Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0160-6689","issn-type":"print"},{"issue":"8","key":"ref110","doi-asserted-by":"publisher","first-page":"e1000","DOI":"10.4088\/jcp.16m11404","article-title":"Preventive Effects of Lamotrigine in Bipolar II Versus Bipolar I Disorder","volume":"78","author":"Takeshi Terao","year":"2017","journal-title":"The Journal of Clinical Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0160-6689","issn-type":"print"},{"issue":"1","key":"ref111","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/hrp.0000000000000161","article-title":"Clinical and Environmental Risk Factors for Bipolar Disorder: Review of Prospective Studies","volume":"26","author":"Ciro Marangoni","year":"2018","journal-title":"Harvard Review of Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/1465-7309","issn-type":"print"},{"issue":"10","key":"ref112","doi-asserted-by":"publisher","first-page":"e01419","DOI":"10.1002\/brb3.1419","article-title":"Clinical applications of transcranial magnetic stimulation in bipolar disorder","volume":"9","author":"Alexandra K. Gold","year":"2019","journal-title":"Brain and Behavior","ISSN":"https:\/\/id.crossref.org\/issn\/2162-3279","issn-type":"print"},{"key":"ref113","article-title":"Alkermes Announces FDA Approval of LYBALVITM for the Treatment of Schizophrenia and Bipolar I Disorder | BioSpace"},{"issue":"4","key":"ref114","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1002\/cpdd.688","article-title":"Effect of Food on the Pharmacokinetics of a Combination of Olanzapine and Samidorphan","volume":"8","author":"Lei Sun","year":"2019","journal-title":"Clinical Pharmacology in Drug Development","ISSN":"https:\/\/id.crossref.org\/issn\/2160-763X","issn-type":"print"},{"issue":"7","key":"ref115","doi-asserted-by":"publisher","first-page":"455","DOI":"10.2165\/11589060-000000000-00000","article-title":"Weight gain and changes in metabolic variables following olanzapine treatment in schizophrenia and bipolar disorder","volume":"31","author":"Leslie Citrome","year":"2011","journal-title":"Clinical Drug Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/1173-2563","issn-type":"print"},{"issue":"12","key":"ref116","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1176\/appi.ajp.2020.20091425","article-title":"How Much of an Advance Is the Addition of Samidorphan to Olanzapine?","volume":"177","author":"Robert W. Buchanan","year":"2020","journal-title":"American Journal of Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0002-953X","issn-type":"print"},{"issue":"10","key":"ref117","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1177\/0269881119856850","article-title":"Samidorphan mitigates olanzapine-induced weight gain and metabolic dysfunction in rats and non-human primates","volume":"33","author":"Jacobi I Cunningham","year":"2019","journal-title":"Journal of Psychopharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0269-8811","issn-type":"print"},{"issue":"9","key":"ref118","doi-asserted-by":"publisher","first-page":"3402","DOI":"10.1172\/jci93362","article-title":"The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C","volume":"127","author":"Caleb C. Lord","year":"2017","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"1","key":"ref119","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1815","article-title":"Effects of Olanzapine and Haloperidol on the Metabolic Status of Healthy Men","volume":"95","year":"2010","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.schres.2017.10.014","article-title":"A randomized, double-blind, placebo-controlled proof of concept study to evaluate samidorphan in the prevention of olanzapine-induced weight gain in healthy volunteers","volume":"195","author":"Bernard L. Silverman","year":"2018","journal-title":"Schizophrenia Research","ISSN":"https:\/\/id.crossref.org\/issn\/0920-9964","issn-type":"print"},{"issue":"6","key":"ref121","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1176\/appi.ajp.2018.18030280","article-title":"Mitigation of Olanzapine-Induced Weight Gain With Samidorphan, an Opioid Antagonist: A Randomized Double-Blind Phase 2 Study in Patients With Schizophrenia","volume":"176","author":"William F. Martin","year":"2019","journal-title":"American Journal of Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0002-953X","issn-type":"print"},{"issue":"10265","key":"ref122","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1016\/s0140-6736(20)31544-0","article-title":"Bipolar disorders","volume":"396","author":"Roger S McIntyre","year":"2020","journal-title":"The Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"}],"container-title":["Health Psychology Research"],"original-title":[],"link":[{"URL":"https:\/\/api.healthpr.org\/uploads\/file\/asp\/20250405183529c9fad3926.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.healthpr.org\/uploads\/file\/asp\/20250405183529c9fad3926.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T02:45:26Z","timestamp":1760409926000},"score":1,"resource":{"primary":{"URL":"https:\/\/healthpr.org\/journal\/HPR\/10\/2\/10.52965\/001c.34224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,25]]},"references-count":122,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,4,26]]}},"URL":"https:\/\/doi.org\/10.52965\/001c.34224","relation":{},"ISSN":["2420-8124"],"issn-type":[{"value":"2420-8124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,25]]}}}