{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:44:00Z","timestamp":1787031840064,"version":"build-2736575974"},"reference-count":28,"publisher":"Open Medical Publishing","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The aim of this prospective study was to define the perioperative trend of C-reactive protein (CRP) in non-infected total knee arthroplasty (TKA). CRP was evaluated in 42 patients the day before surgery and 4 and 30 days after surgery. Functional and radiological evaluation was scheduled for 3, 6, and 12 months after surgery. Preoperatively, the median CRP was 3.2 mg\/L (IQR,3.2-4.2) (reference range, 0-5 mg\/L); 4 and 30 days after surgery, it measured 57.6 mg\/L (IQR,36.1-96.4) and 5.3 mg\/L (IQR,3.0-11.8), respectively. There were significant differences between the CRP preoperatively and 4 days after surgery (p&lt;0.001) and between CPR levels 4 and 30 days after surgery (p&lt;0.001) but not between CRP values preoperatively and 30 days after surgery (p=0.181). Higher preoperative CRP was associated to heart disease and chronic renal failure (r=0.329, p=0.036, and r=0.437, p=0.004, respectively). Four days after surgery, higher CRP was associated to older patients (r=0.311, p=0.048).<\/jats:p>\n                  <jats:p>In summary, 30 days after primary non-infected TKA, CRP levels were comparable to preoperative values. Older age and comorbidities should be carefully evaluated using postoperative CRP as diagnostic marker for the early detection of infection.<\/jats:p>","DOI":"10.52965\/001c.36589","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T11:18:02Z","timestamp":1656501482000},"source":"Crossref","is-referenced-by-count":12,"title":["Trend of Perioperative CRP (C-Reactive Protein) Levels in Non-Infected Total Knee Arthroplasty"],"prefix":"10.52965","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8742-5612","authenticated-orcid":false,"given":"Michele","family":"Mercurio","sequence":"first","affiliation":[{"name":"\u201cMagna Gr\u00e6cia\u201d University, \u201cMater Domini\u201d University Hospital, V.le Europa, (loc. Germaneto), 88100, Catanzaro, Italy","department":["Department of Orthopaedic and Trauma Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4915-046X","authenticated-orcid":false,"given":"Olimpio","family":"Galasso","sequence":"additional","affiliation":[{"name":"\u201cMagna Gr\u00e6cia\u201d University, \u201cMater Domini\u201d University Hospital, V.le Europa, (loc. Germaneto), 88100, Catanzaro, Italy","department":["Department of Orthopaedic and Trauma Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3453-2043","authenticated-orcid":false,"given":"Filippo","family":"Familiari","sequence":"additional","affiliation":[{"name":"\u201cMagna Gr\u00e6cia\u201d University, \u201cMater Domini\u201d University Hospital, V.le Europa, (loc. Germaneto), 88100, Catanzaro, Italy","department":["Department of Orthopaedic and Trauma Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Iann\u00f2","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic and Trauma Surgery, \u201cMagna Gr\u00e6cia\u201d University, \u201cMater Domini\u201d University Hospital, V.le Europa, (loc. Germaneto), 88100, Catanzaro, Italy; Department of Surgery, Division of Orthopedics and Trauma Surgery, \u201cG. Jazzolino\u201d Hospital, Piazza Fleming, 89900, Vibo Valentia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine Fabio","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic and Trauma Surgery, \u201cMagna Gr\u00e6cia\u201d University, \u201cMater Domini\u201d University Hospital, V.le Europa, (loc. Germaneto), 88100, Catanzaro, Italy; Hip Diseases and Joint Replacement Surgery Unit; Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3207-6651","authenticated-orcid":false,"given":"Davide","family":"Castioni","sequence":"additional","affiliation":[{"name":"\u201cMagna Gr\u00e6cia\u201d University, \u201cMater Domini\u201d University Hospital, V.le Europa, (loc. Germaneto), 88100, Catanzaro, Italy","department":["Department of Orthopaedic and Trauma Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8256-7697","authenticated-orcid":false,"given":"Giorgio","family":"Gasparini","sequence":"additional","affiliation":[{"name":"\u201cMagna Gr\u00e6cia\u201d University, \u201cMater Domini\u201d University Hospital, V.le Europa, (loc. 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