{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:08:07Z","timestamp":1788368887528,"version":"build-2803163510"},"reference-count":135,"publisher":"Open Medical Publishing","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Morbidity and mortality related to opioid use has generated a public health crisis in the United States. Total knee arthroplasty (TKA) is an increasingly common procedure and is often accompanied by post-operative opioid utilization. Unfortunately, post-operative opioid usage after TKA has been shown to lead to higher rates of complications, longer hospital stays, increased costs, and more frequent need for revision surgery. Pre-operative opioid utilization has been shown to be one of the most important predictors of post-operative opioid usage. Additional risk factors for continued post-operative opioid utilization after TKA include pre-operative substance and tobacco use as well as higher post-operative prescription dosages, younger age, female gender, and Medicaid insurance. One method for mitigating excessive post-operative opioid utilization are Enhanced Recovery After Surgery (ERAS) protocols, which include a multidisciplinary approach that focuses on perioperative factors to optimize patient recovery and function after surgery. Additional strategies include multimodal pain regimens with epidural anesthetics, extended duration local anesthetics and adjuvants, and ultrasound guided peripheral nerve blocks. In recent years, opioid prescribing duration limitations have also been put into place by state and federal government, hospital systems, and ambulatory surgery centers making effective acute pain management imperative for all stakeholders. In this regard, as rates of TKA continue to increase across the United States, multidisciplinary efforts by all stakeholders are needed to ensure adequate pain control while preventing the negative sequalae of opioid medications.<\/jats:p>","DOI":"10.52965\/001c.37496","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T21:42:20Z","timestamp":1661809340000},"source":"Crossref","is-referenced-by-count":6,"title":["The Ramifications of Opioid Utilization and Outcomes of Alternative Pain Control Strategies for Total Knee Arthroplasties"],"prefix":"10.52965","volume":"14","author":[{"given":"Kevin","family":"Berardino","sequence":"first","affiliation":[{"name":"Georgetown University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin H.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Ricotti","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00fwdyt59","id-type":"ROR","asserted-by":"publisher"}],"name":"George Washington University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Popovsky","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Civilette","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Urits","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Science Center Shreveport","department":["Department of Anesthesiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Viswanath","sequence":"additional","affiliation":[{"name":"Innovative Pain and Wellness; Department of Anesthesiology, Creighton University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Sherman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04vmvtb21","id-type":"ROR","asserted-by":"publisher"}],"name":"Tulane University","department":["Department of Orthopedic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D.","family":"Kaye","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Science Center Shreveport","department":["Department of Anesthesiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"30777","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"issue":"35","key":"ref1","doi-asserted-by":"publisher","first-page":"e7836","DOI":"10.1097\/md.0000000000007836","article-title":"Preoperative intravenous glucocorticoids can reduce postoperative acute pain following total knee arthroplasty","volume":"96","author":"Xiangcheng Liu","year":"2017","journal-title":"Medicine (Baltimore)","ISSN":"https:\/\/id.crossref.org\/issn\/0025-7974","issn-type":"print"},{"issue":"9","key":"ref2","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1007\/s40262-016-0383-6","article-title":"Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy","volume":"55","author":"Marko A. 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