{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:31:36Z","timestamp":1792168296438,"version":"4.4.0"},"reference-count":47,"publisher":"Journal of Biological Methods","issue":"3","license":[{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HPR"],"abstract":"<jats:p>Male sexual dysfunction is a series of conditions, most notably including erectile dysfunction (ED), Peyronie&amp;rsquo;s disease (PD), and premature ejaculation (PE), defined by impaired sexual functioning. The prevalence of male sexual dysfunction increases with age and is relatively high with greater than 50% of men aged 40 to 70 describing some degree of erectile dysfunction. Risk factors for male sexual dysfunction include age, diabetes mellitus (DM), cancer, stroke, hypertension, penile trauma, depression, anxiety, and disturbance in central serotonin neurotransmission and 5-HT postsynaptic receptor functioning. Sexual questionnaires including the International Index of Erectile Dysfunction, Sexual Health Inventory for Men, and the Premature Ejaculation Diagnostic Tool are useful in screening for these disorders. Focused history and physical can establish diagnoses. For a condition to be diagnosed as male sexual dysfunction, the patient or their partner must view their sexual functioning as impaired. Treatment of male sexual dysfunction is etiology dependent. For ED, first-line therapy is a phosphodiesterase-5 inhibitor or mental health care for psychogenic ED. More complicated cases may be treated with injections, surgery, or shockwave therapy. PD is either treated with medications for pain management, collagenase clostridium histolyticum injection, corpoplasty, plication, or shockwave therapy. PE may be treated behaviorally or with SSRIs as first line medication.<\/jats:p>","DOI":"10.52965\/001c.37533","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T16:56:55Z","timestamp":1661014615000},"page":"1","source":"Crossref","is-referenced-by-count":56,"title":["Male Sexual Dysfunction\u00a0"],"prefix":"10.14440","volume":"10","author":[{"given":"Danyon","family":"Anderson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Laforge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie","family":"M. Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Vanlangendonck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal","family":"Hasoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Viswanath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"D. Kaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Urits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5574","published-online":{"date-parts":[[2022,8,20]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"publisher","first-page":"16003","DOI":"10.1038\/nrdp.2016.3","article-title":"Erectile dysfunction","volume":"2","author":"Faysal A. Yafi","year":"2016","journal-title":"Nature Reviews Disease Primers","ISSN":"https:\/\/id.crossref.org\/issn\/2056-676X","issn-type":"print"},{"issue":"17","key":"ref2","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1001\/jama.2016.12284","article-title":"Erectile Dysfunction","volume":"316","author":"Bobby B. Najari","year":"2016","journal-title":"JAMA","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"issue":"17","key":"ref3","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1097\/brs.0000000000003049","article-title":"Predictive Factors of Male Sexual Dysfunction after Traumatic Spinal Cord Injury","volume":"44","author":"Josepha Karinne D. Oliveira Ferro","year":"2019","journal-title":"Spine (Phila Pa 1976)","ISSN":"https:\/\/id.crossref.org\/issn\/0362-2436","issn-type":"print"},{"issue":"5","key":"ref4","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/j.fertnstert.2015.07.1155","article-title":"Psychosocial aspects of ejaculatory dysfunction and male reproduction","volume":"104","author":"John P. Wincze","year":"2015","journal-title":"Fertility and Sterility","ISSN":"https:\/\/id.crossref.org\/issn\/0015-0282","issn-type":"print"},{"issue":"3","key":"ref5","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.juro.2018.05.004","article-title":"Erectile Dysfunction: AUA Guideline","volume":"200","author":"Arthur L. Burnett","year":"2018","journal-title":"Journal of Urology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-5347","issn-type":"print"},{"issue":"1109","key":"ref6","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1136\/postgradmedj-2017-135233","article-title":"Effect of prescription medications on erectile dysfunction","volume":"94","author":"Shirin Razdan","year":"2018","journal-title":"Postgraduate Medical Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0032-5473","issn-type":"print"},{"issue":"1","key":"ref7","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.mcna.2010.08.016","article-title":"Evaluation and Treatment of Erectile Dysfunction","volume":"95","author":"Maarten Albersen","year":"2011","journal-title":"Medical Clinics of North America","ISSN":"https:\/\/id.crossref.org\/issn\/0025-7125","issn-type":"print"},{"issue":"1","key":"ref8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1743-6109.2012.02823.x","article-title":"Standard Operating Procedures for Taking a Sexual History","volume":"10","author":"Stanley E. Althof","year":"2013","journal-title":"The Journal of Sexual Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1743-6095","issn-type":"print"},{"issue":"3","key":"ref9","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.juro.2015.05.098","article-title":"Peyronie\u2019s Disease: AUA Guideline","volume":"194","author":"Ajay Nehra","year":"2015","journal-title":"Journal of Urology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-5347","issn-type":"print"},{"issue":"2","key":"ref10","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s11930-015-0045-y","article-title":"Peyronie\u2019s Disease: A Review of Etiology, Diagnosis, and Management","volume":"7","author":"Aylin N. Bilgutay","year":"2015","journal-title":"Current Sexual Health Reports","ISSN":"https:\/\/id.crossref.org\/issn\/1548-3584","issn-type":"print"},{"key":"ref11","first-page":"18","article-title":"Gender and Sexual Health: Sexual Dysfunction","volume":"449","author":"J.D. Stringer","year":"2016","journal-title":"FP Essent"},{"issue":"6","key":"ref12","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1111\/iju.14230","article-title":"Peyronie\u2019s disease: Contemporary evaluation and management","volume":"27","author":"Matthew J Ziegelmann","year":"2020","journal-title":"International Journal of Urology","ISSN":"https:\/\/id.crossref.org\/issn\/0919-8172","issn-type":"print"},{"issue":"3","key":"ref13","first-page":"33","article-title":"Imaging modalities and clinical assesment in men affected with Peyronie\u2019s disease","volume":"76","author":"E. Paw\u0142owska","year":"2011","journal-title":"Pol J Radiol"},{"issue":"5","key":"ref14","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/ijir.2008.30","article-title":"Peyronie's disease: a critical appraisal of current diagnosis and treatment","volume":"20","author":"J F Smith","year":"2008","journal-title":"International Journal of Impotence Research","ISSN":"https:\/\/id.crossref.org\/issn\/0955-9930","issn-type":"print"},{"issue":"5","key":"ref15","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/sj.ijir.3900569","article-title":"Color Doppler ultrasound assessment of penile vascular system in men with Peyronie's disease","volume":"12","author":"A Kadio\u011flu","year":"2000","journal-title":"International Journal of Impotence Research","ISSN":"https:\/\/id.crossref.org\/issn\/0955-9930","issn-type":"print"},{"issue":"3","key":"ref16","doi-asserted-by":"publisher","first-page":"399","DOI":"10.5534\/wjmh.200065","article-title":"The Natural History of Peyronie's Disease","volume":"39","author":"Fabrizio di Maida","year":"2021","journal-title":"The World Journal of Men's Health","ISSN":"https:\/\/id.crossref.org\/issn\/2287-4208","issn-type":"print"},{"key":"ref17","series-title":"Diagnostic and Statistical Manual of Mental Disorders","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596.dsm13","article-title":"Sexual Dysfunctions","year":"2013"},{"issue":"6","key":"ref18","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1097\/yco.0000000000000097","article-title":"Diagnosis of erectile dysfunction","volume":"27","author":"Sidney Glina","year":"2014","journal-title":"Current Opinion in Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0951-7367","issn-type":"print"},{"issue":"23","key":"ref19","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1001\/jama.294.23.2996","article-title":"Erectile Dysfunction and Subsequent Cardiovascular Disease","volume":"294","author":"Ian M. Thompson","year":"2005","journal-title":"JAMA","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"issue":"5","key":"ref20","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.3390\/cells9051250","article-title":"Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction","volume":"9","author":"Ming-Che Liu","year":"2020","journal-title":"Cells","ISSN":"https:\/\/id.crossref.org\/issn\/2073-4409","issn-type":"print"},{"issue":"6","key":"ref21","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1002\/cpt.261","article-title":"Pharmacotherapeutic Management of Erectile Dysfunction","volume":"98","author":"D.J. Hawksworth","year":"2015","journal-title":"Clinical Pharmacology & Therapeutics","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9236","issn-type":"print"},{"issue":"503","key":"ref22","first-page":"28","article-title":"Men\u2019s Health: Male Sexual Dysfunction","volume":"503","author":"K.T. Rew","year":"2021","journal-title":"FP Essent"},{"issue":"5","key":"ref23","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1177\/1756287210362069","article-title":"Non-invasive management of primary phosphodiesterase type 5 inhibitor failure in patients with erectile dysfunction","volume":"1","author":"Gregory Lowe","year":"2009","journal-title":"Therapeutic Advances in Urology","ISSN":"https:\/\/id.crossref.org\/issn\/1756-2872","issn-type":"print"},{"issue":"2","key":"ref24","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.pop.2019.02.006","article-title":"Erectile Dysfunction","volume":"46","author":"Gretchen M. Irwin","year":"2019","journal-title":"Primary Care: Clinics in Office Practice","ISSN":"https:\/\/id.crossref.org\/issn\/0095-4543","issn-type":"print"},{"issue":"1","key":"ref25","doi-asserted-by":"publisher","first-page":"16003","DOI":"10.1038\/nrdp.2016.3","article-title":"Erectile dysfunction","volume":"2","author":"Faysal A. Yafi","year":"2016","journal-title":"Nature Reviews Disease Primers","ISSN":"https:\/\/id.crossref.org\/issn\/2056-676X","issn-type":"print"},{"issue":"1","key":"ref26","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.sxmr.2020.03.005","article-title":"Novel Treatments of Erectile Dysfunction: Review of the Current Literature","volume":"9","author":"Omer A. Raheem","year":"2021","journal-title":"Sexual Medicine Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/2050-0521","issn-type":"print"},{"issue":"4","key":"ref27","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/s41443-020-00406-3","article-title":"Role of regenerative therapies on erectile dysfunction after radical prostatectomy","volume":"33","author":"S. T. Hansen","year":"2021","journal-title":"International Journal of Impotence Research","ISSN":"https:\/\/id.crossref.org\/issn\/0955-9930","issn-type":"print"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.addr.2014.11.012","article-title":"Stem cell treatment of erectile dysfunction","volume":"82-83","author":"Amjad Alwaal","year":"2015","journal-title":"Advanced Drug Delivery Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0169-409X","issn-type":"print"},{"issue":"3","key":"ref29","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.juro.2015.05.098","article-title":"Peyronie\u2019s disease: AUA guideline","volume":"194","author":"Ajay Nehra","year":"2015","journal-title":"Journal of Urology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-5347","issn-type":"print"},{"issue":"3","key":"ref30","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1097\/ju.0000000000002392","article-title":"Disorders of Ejaculation: An AUA\/SMSNA Guideline","volume":"207","author":"Alan W. Shindel","year":"2022","journal-title":"Journal of Urology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-5347","issn-type":"print"},{"issue":"4","key":"ref31","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1002\/rmb2.12289","article-title":"Clinical review of ejaculatory dysfunction","volume":"18","author":"Toshikazu Otani","year":"2019","journal-title":"Reproductive Medicine and Biology","ISSN":"https:\/\/id.crossref.org\/issn\/1445-5781","issn-type":"print"},{"issue":"3","key":"ref32","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.sxmr.2017.11.002","article-title":"Couplepause: A New Paradigm in Treating Sexual Dysfunction During Menopause and Andropause","volume":"6","author":"Emmanuele A. Jannini","year":"2018","journal-title":"Sexual Medicine Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/2050-0521","issn-type":"print"},{"issue":"2","key":"ref33","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.pop.2019.02.006","article-title":"Erectile Dysfunction","volume":"46","author":"Gretchen M. Irwin","year":"2019","journal-title":"Primary Care: Clinics in Office Practice","ISSN":"https:\/\/id.crossref.org\/issn\/0095-4543","issn-type":"print"},{"issue":"3","key":"ref34","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1177\/1557988315596566","article-title":"Erectile Dysfunction: A Review of Historical Treatments With a Focus on the Development of the Inflatable Penile Prosthesis","volume":"11","author":"Kristen Gurtner","year":"2017","journal-title":"American Journal of Men's Health","ISSN":"https:\/\/id.crossref.org\/issn\/1557-9883","issn-type":"print"},{"issue":"1","key":"ref35","doi-asserted-by":"publisher","first-page":"32","DOI":"10.4103\/aja.aja_27_21","article-title":"Ten-year experience with penile prosthetic surgery for the treatment of erectile dysfunction: outcomes of a tertiary referral center and predictors of early prosthetic infection","volume":"24","author":"Franco Palmisano","year":"2022","journal-title":"Asian Journal of Andrology","ISSN":"https:\/\/id.crossref.org\/issn\/1008-682X","issn-type":"print"},{"issue":"2","key":"ref36","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/iju.14157","article-title":"Surgical niche for the treatment of erectile dysfunction","volume":"27","author":"Cheng-Hsing Hsieh","year":"2020","journal-title":"International Journal of Urology","ISSN":"https:\/\/id.crossref.org\/issn\/0919-8172","issn-type":"print"},{"issue":"11","key":"ref37","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1016\/j.jsxm.2016.09.008","article-title":"External Mechanical Devices and Vascular Surgery for Erectile Dysfunction","volume":"13","author":"Landon W. Trost","year":"2016","journal-title":"The Journal of Sexual Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1743-6095","issn-type":"print"},{"issue":"4","key":"ref38","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.ucl.2021.07.002","article-title":"Is There a Role for Vascular Surgery in the Contemporary Management of Erectile Dysfunction?","volume":"48","author":"Ricardo Munarriz","year":"2021","journal-title":"Urologic Clinics of North America","ISSN":"https:\/\/id.crossref.org\/issn\/0094-0143","issn-type":"print"},{"issue":"2","key":"ref39","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jsxm.2018.12.016","article-title":"The Basic Science Behind Low-Intensity Extracorporeal Shockwave Therapy for Erectile Dysfunction: A Systematic Scoping Review of Pre-Clinical Studies","volume":"16","author":"Ioannis Sokolakis","year":"2019","journal-title":"The Journal of Sexual Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1743-6095","issn-type":"print"},{"issue":"1","key":"ref40","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.sxmr.2020.01.006","article-title":"Review of the Current Status of Low Intensity Extracorporeal Shockwave Therapy (Li-ESWT) in Erectile Dysfunction (ED), Peyronie's Disease (PD), and Sexual Rehabilitation After Radical Prostatectomy With Special Focus on Technical Aspects of the Different Marketed ESWT Devices Including Personal Experiences in 350 Patients","volume":"9","author":"Hartmut Porst","year":"2021","journal-title":"Sexual Medicine Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/2050-0521","issn-type":"print"},{"issue":"3","key":"ref41","doi-asserted-by":"publisher","first-page":"318","DOI":"10.21037\/tau.2016.05.01","article-title":"Plication procedures\u2014excisional and incisional corporoplasty and imbrication for Peyronie\u2019s disease","volume":"5","author":"Roger Chen","year":"2016","journal-title":"Translational Andrology and Urology","ISSN":"https:\/\/id.crossref.org\/issn\/2223-4683","issn-type":"print"},{"issue":"5","key":"ref42","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1016\/j.fertnstert.2015.09.029","article-title":"Delayed orgasm and anorgasmia","volume":"104","author":"Lawrence C. Jenkins","year":"2015","journal-title":"Fertility and Sterility","ISSN":"https:\/\/id.crossref.org\/issn\/0015-0282","issn-type":"print"},{"issue":"2","key":"ref43","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jsxm.2015.12.034","article-title":"Incidence and Prevalence of Sexual Dysfunction in Women and Men: A Consensus Statement from the Fourth International Consultation on Sexual Medicine 2015","volume":"13","author":"Marita P. McCabe","year":"2016","journal-title":"The Journal of Sexual Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1743-6095","issn-type":"print"},{"issue":"4","key":"ref44","doi-asserted-by":"publisher","DOI":"10.1177\/1557988320937200","article-title":"Epidemiology of Male Sexual Dysfunction in Asian and European Regions: A Systematic Review","volume":"14","author":"Muhammad Irfan","year":"2020","journal-title":"American Journal of Men's Health","ISSN":"https:\/\/id.crossref.org\/issn\/1557-9883","issn-type":"print"},{"issue":"4","key":"ref45","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.sxmr.2017.05.004","article-title":"Erectile Dysfunction in Young Men\u2014A Review of the Prevalence and Risk Factors","volume":"5","author":"Hoang Minh Tue Nguyen","year":"2017","journal-title":"Sexual Medicine Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/2050-0521","issn-type":"print"},{"issue":"4","key":"ref46","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/j.1439-0272.2006.00730.x","article-title":"Epidemiology of sexual dysfunction in the male population","volume":"38","author":"M. E. Beutel","year":"2006","journal-title":"Andrologia","ISSN":"https:\/\/id.crossref.org\/issn\/0303-4569","issn-type":"print"},{"issue":"4","key":"ref47","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1111\/j.1743-6109.2010.01778.x","article-title":"ORIGINAL ARTICLES: Definitions\/Epidemiology\/Risk Factors for Sexual Dysfunction","volume":"7","author":"Ronald W. Lewis","year":"2010","journal-title":"The Journal of Sexual Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1743-6095","issn-type":"print"}],"container-title":["Health Psychology Research"],"original-title":[],"link":[{"URL":"https:\/\/api.healthpr.org\/uploads\/file\/asp\/20250406123320415ed5945.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.healthpr.org\/uploads\/file\/asp\/20250406123320415ed5945.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T03:04:07Z","timestamp":1760411047000},"score":1,"resource":{"primary":{"URL":"https:\/\/healthpr.org\/journal\/HPR\/10\/3\/10.52965\/001c.37533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,20]]},"references-count":47,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,8,20]]}},"URL":"https:\/\/doi.org\/10.52965\/001c.37533","relation":{},"ISSN":["2420-8124"],"issn-type":[{"value":"2420-8124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,20]]}}}