{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:41:25Z","timestamp":1789753285539,"version":"4.0.1"},"reference-count":49,"publisher":"Open Medical Publishing","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"\n Background<\/jats:title>\n The opioid crisis has become a present concern in the medical field. In an effort to address these complications, antineuropathic pain medications have been considered as alternatives to prescribed opioids.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This review focuses on the analgesic effects of neuromodulators, such as gabapentin, duloxetine, and pregabalin, that provide room for less dependence on narcotic analgesics following orthopedic surgery.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n During the database searches, 1,033 records were identified as a preliminary result. After duplicates were removed, an initial screen of each article was completed which identified records to be removed due to absence of a full-text article. Articles were excluded if they were not either prospective or retrospective, showcased an irrelevant medication (such as tricyclic antidepressants) which are not pertinent to this review, or deemed to be unrelated to the topic.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Ultimately, 19 articles were selected. Three different drugs, gabapentin, pregabalin, and duloxetine, were analyzed to compile data on the effectiveness of preventing opioid overuse and addiction following hand surgery.\n This review identifies potential evidence that peri-operative gabapentin, pregabalin, and duloxetine administration decreases post-operative pain and lowers opioid dependency.<\/jats:named-content>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Gabapentin, pregabalin, and duloxetine have potential to further decrease post-operative pain and lower opioid dependency. This review creates an opening for further research in hand surgery to assess an updated protocol for pain management to reduce opioid dependency.<\/jats:named-content>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.52965\/001c.93012","type":"journal-article","created":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T12:41:53Z","timestamp":1710679313000},"source":"Crossref","is-referenced-by-count":3,"title":["Antineuropathic Pain Management After Orthopedic Surgery: A Systematic Review"],"prefix":"10.52965","volume":"16","author":[{"given":"Taylor","family":"Harder","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/033ztpr93","id-type":"ROR","asserted-by":"publisher"}],"name":"Texas Tech University Health Sciences Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Harder","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/033ztpr93","id-type":"ROR","asserted-by":"publisher"}],"name":"Texas Tech University Health Sciences Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gracie","family":"Baum","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/033ztpr93","id-type":"ROR","asserted-by":"publisher"}],"name":"Texas Tech University Health Sciences Center","department":["Orthopaedic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Cox","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/033ztpr93","id-type":"ROR","asserted-by":"publisher"}],"name":"Texas Tech University Health Sciences Center","department":["Orthopaedic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Harder","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/033ztpr93","id-type":"ROR","asserted-by":"publisher"}],"name":"Texas Tech University Health Sciences Center","department":["Orthopaedic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9587-2093","authenticated-orcid":false,"given":"Evan","family":"Hernandez","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0405mnx93","id-type":"ROR","asserted-by":"publisher"}],"name":"Texas Tech University","department":["Community, Family, and Addiction Sciences"]},{"id":[{"id":"https:\/\/ror.org\/033ztpr93","id-type":"ROR","asserted-by":"publisher"}],"name":"Texas Tech University Health Sciences Center","department":["Department of Orthopaedic Hand Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7538-2857","authenticated-orcid":false,"given":"Brendan","family":"MacKay","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/033ztpr93","id-type":"ROR","asserted-by":"publisher"}],"name":"Texas Tech University Health Sciences Center","department":["Orthopaedic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"30777","published-online":{"date-parts":[[2024,3,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd008921.pub2","article-title":"Neuromodulators for pain management in rheumatoid arthritis","volume":"18;1(1):CD008921","author":"Bethan L Richards","year":"2012","journal-title":"Cochrane Database of Systematic Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/1465-1858","issn-type":"print"},{"key":"ref2","article-title":"Miller's anesthesia","author":"M.A. Gropper","year":"2020"},{"issue":"2","key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd007938.pub4","article-title":"Gabapentin for chronic neuropathic pain in adults","volume":"2020","author":"Philip J Wiffen","year":"2017","journal-title":"Cochrane Database Syst Rev","ISSN":"https:\/\/id.crossref.org\/issn\/1465-1858","issn-type":"print"},{"issue":"1","key":"ref4","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1001\/jamaneurol.2018.3077","article-title":"Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults With Chronic Sciatica: A Randomized Clinical Trial","volume":"76","author":"Kelvin Robertson","year":"2019","journal-title":"JAMA Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/2168-6149","issn-type":"print"},{"issue":"10","key":"ref5","doi-asserted-by":"publisher","first-page":"661","DOI":"10.2165\/11536200-000000000-00000","article-title":"A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin","volume":"49","author":"Howard N. 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