{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:53:41Z","timestamp":1777578821408,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,6,23]],"date-time":"2010-06-23T00:00:00Z","timestamp":1277251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Alzheimer disease (AD) and age-related ocular diseases are characterized by inflammation and accumulation of insoluble proteins. We aimed to investigate the detectability and clinical relevance of a panel of AD-related markers, such as Alzheimer peptides and chemokines, in the aqueous humor (AH) samples taken from patients with cataract only, or cataract and 1 other ocular disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The AH samples were obtained during cataract surgery from patients with cataract only (n=162), cataract and glaucoma (n=21), cataract and exfoliation (PEX) (n=31), cataract and macular degeneration (n=36), and cataract and diabetic retinopathy (n=16). The AD peptides (A\u03b2\n                      <jats:sub>1\u201342<\/jats:sub>\n                      , A\u03b2\n                      <jats:sub>1\u201340<\/jats:sub>\n                      , A\u03b2\n                      <jats:sub>1\u201338<\/jats:sub>\n                      ) and chemokines (eotaxin, eotaxin 3, interleukin [IL]-8, inducible protein-10, monocyte chemotactic protein [MCP]-1, MCP-4, macrophage-derived chemokine, macrophage inflammatory protein-1\u03b2, thymus and activation-regulated chemokine) were quantified by using multiplex immunoassays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The levels of the AH peptides (A\u03b2\n                      <jats:sub>1\u201338<\/jats:sub>\n                      , A\u03b2\n                      <jats:sub>1\u201340<\/jats:sub>\n                      , A\u03b2\n                      <jats:sub>1\u201342<\/jats:sub>\n                      ) did not differ between disease groups. Independently of disease group, the A\u03b2\n                      <jats:sub>1\u201338<\/jats:sub>\n                      levels correlated with A\u03b2\n                      <jats:sub>1\u201340<\/jats:sub>\n                      and A\u03b2\n                      <jats:sub>1\u201342<\/jats:sub>\n                      (p&lt;0.001, n=277). Notably the ratio A\u03b2\n                      <jats:sub>1\u201342<\/jats:sub>\n                      to A\u03b2\n                      <jats:sub>1\u201338<\/jats:sub>\n                      differed between PEX and macular degeneration (mean 95% confidence interval [CI] = 8.12 [11.3\u20133.99] vs 2.23 [2.67\u20130.52], p=0.003). Among chemokines examined, only MCP-1 and IL-8 were detected in about 90% to 46% of all analyzed (n=266) samples. Higher levels of AH IL-8 were found in the glaucoma group than in cataract only (p=0.011). Independently of disease group, a correlation was observed between AH MCP-1 and IL-8 (rho=0.275, p&lt;0.001, n=266) and between MCP-1 and A\u03b2\n                      <jats:sub>1\u201340<\/jats:sub>\n                      (rho=0.239, p&lt;0.001, n=266).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings highlight pathologic similarities between AD and eye diseases, and show the potential of modern technologies to detect AD biomarkers in age-related eye diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.2010.2108","type":"journal-article","created":{"date-parts":[[2010,11,18]],"date-time":"2010-11-18T04:59:29Z","timestamp":1290056369000},"page":"104-111","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Detection of Alzheimer Peptides and 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