{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:07:24Z","timestamp":1790222844834,"version":"4.1.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T00:00:00Z","timestamp":1280275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Ophthalmology"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study was carried out to determine the frequency of clinical diagnostic criteria in patients with Alagille syndrome (AGS) in comparison to a group of children with cholestasis and histologically proven neonatal hepatitis (NH). The type and frequency of ocular manifestations are highlighted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>According to histologic findings on liver biopsy, the 32 patients included in the study were classified into 2 groups: group 1 had paucity of interlobular bile ducts (PILBD) (n=13) and at least 3 of 5 characteristics of AGS and group 2 had NH on liver biopsy (n=19).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age of patients with AGS was higher than in group 2 (3.9 vs 1.6 years) (p&lt;0.05). Pruritus was a significant symptom in the AGS group (p&lt;0.05). Characteristic fades was detected in 61.5% of the AGS group. None of our patients with AGS had vertebral anomalies. Although cardiac murmurs were heard in 5 patients with AGS, cardiac anomalies were detected in only 3 by echocardiography: pulmonary stenosis in 2 patients and patent foramen ovale in 1. Posterior embryotoxon (PE) was detected in 69.2% of patients with AGS as compared to 10.5% of the NH group. Optic nerve drusen was detected in 91% of patients with AGS as compared to 5.3% of patients with NH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Optic nerve drusen was the most common finding in AGS, followed by PE and facial features. Ocular ultrasound needs to be performed in all cholestatic infants with PILBD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5301\/ejo.2010.5675","type":"journal-article","created":{"date-parts":[[2010,10,31]],"date-time":"2010-10-31T09:10:19Z","timestamp":1288516219000},"page":"199-206","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Alagille Syndrome: Clinical and Ocular Pathognomonic Features"],"prefix":"10.1177","volume":"21","author":[{"given":"Nehal M.","family":"El-Koofy","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Cairo University, Cairo - Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randa","family":"El-Mahdy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cairo University, Cairo - Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona E.","family":"Fahmy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Research Institute of Ophthalmology, Cairo - Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"El-Hennawy","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cairo University, Cairo - Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Y.","family":"Farag","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Research Institute of Ophthalmology, Cairo - Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa M.","family":"El-Karaksy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cairo University, Cairo - Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,7,28]]},"reference":[{"key":"bibr1-EJO.2010.5675","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80706-2"},{"key":"bibr2-EJO.2010.5675","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80153-1"},{"key":"bibr3-EJO.2010.5675","doi-asserted-by":"publisher","DOI":"10.1002\/9781444300536.ch4"},{"key":"bibr4-EJO.2010.5675","doi-asserted-by":"publisher","DOI":"10.1086\/301875"},{"key":"bibr5-EJO.2010.5675","first-page":"402","volume":"102","author":"Hadchouel M.","year":"1978","journal-title":"Arch Pathol Lab Med"},{"key":"bibr6-EJO.2010.5675","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308096"},{"key":"bibr7-EJO.2010.5675","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80345-X"},{"key":"bibr8-EJO.2010.5675","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290331"},{"key":"bibr9-EJO.2010.5675","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840020311"},{"key":"bibr10-EJO.2010.5675","doi-asserted-by":"publisher","DOI":"10.3109\/15513818709161419"},{"key":"bibr11-EJO.2010.5675","doi-asserted-by":"publisher","DOI":"10.1136\/adc.74.3.232"},{"key":"bibr12-EJO.2010.5675","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1989.01070020139047"},{"key":"bibr13-EJO.2010.5675","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)77873-0"},{"key":"bibr14-EJO.2010.5675","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30358-3"},{"key":"bibr15-EJO.2010.5675","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7506-1039-1.50010-6"},{"key":"bibr16-EJO.2010.5675","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.32.4.264"},{"key":"bibr17-EJO.2010.5675","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10579"},{"key":"bibr18-EJO.2010.5675","first-page":"168","volume":"14","author":"Kahn E.","year":"1991","journal-title":"Perspect Pediatr Pathol"},{"key":"bibr19-EJO.2010.5675","first-page":"24","volume":"9","author":"Hadchouel M.","year":"1992","journal-title":"Semin Diagn Pathol"},{"key":"bibr20-EJO.2010.5675","first-page":"775","volume":"104","author":"Frangoulis M.A.","year":"1985","journal-title":"Trans Ophthalmol Soc UK"},{"key":"bibr21-EJO.2010.5675","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90072-6"},{"key":"bibr22-EJO.2010.5675","first-page":"2365","volume-title":"Ophthalmic Pathology: An Atlas and Textbook","author":"Spencer W.H.","year":"1986","edition":"3"}],"container-title":["European Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/EJO.2010.5675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.5301\/EJO.2010.5675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:35:47Z","timestamp":1777404947000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.5301\/EJO.2010.5675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,28]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.5301\/EJO.2010.5675"],"URL":"https:\/\/doi.org\/10.5301\/ejo.2010.5675","relation":{},"ISSN":["1120-6721","1724-6016"],"issn-type":[{"value":"1120-6721","type":"print"},{"value":"1724-6016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,28]]}}}